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Cell Stem Cell @CellStemCell

A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari

Joined June 2009
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1,821 Photos and videos
There's still time to submit your abstract for the @CellPressEvents #CSAging2026, taking place Oct. 4–6, in Seville, Spain. Join leading researchers exploring the mechanisms of aging, healthspan & resilience, including keynote Luigi Ferrucci (@NIHAging). hubs.li/Q04l59460
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Online Now! SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues dlvr.it/TSyVtw #stemcells

SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues

Jia et al. develop SPACE-seq, a versatile technology that integrates CRISPR barcoding with spatial transcriptomics to jointly map cell ancestry, identity, and location. Compatible with diverse...

cell.com
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Online Now! Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells dlvr.it/TSxSmj #stemcells

Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells

Abay-Nørgaard, Mueller, Hänninen, et al. generate cultures of the hypothalamic arcuate nucleus from hPSCs. They show transcriptional similarity to human ARC and response to appetite-regulating cues....

cell.com
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Online Now! Designing complex organoids through developmental principles dlvr.it/TSxPmW #stemcells

Designing complex organoids through developmental principles

Brassard and Wells discuss how next-generation human pluripotent stem cell-derived organoids are achieving greater cellular complexity by more faithfully reproducing developmental processes. Advances...

cell.com
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Human adrenal cortex organoids unlock new frontiers in development, disease, and regenerative therapy dlvr.it/TSxFRn

Human adrenal cortex organoids unlock new frontiers in development, disease, and regenerative...

Recent studies by Mayama et al. and Akkerman et al. established human adrenal cortex organoids that recapitulate fetal and adult adrenal development, offering unprecedented insight into differentia...

cell.com
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Beyond replacement: Immature neurons as resilience partners in the aging hippocampus dlvr.it/TSvLtV

Beyond replacement: Immature neurons as resilience partners in the aging hippocampus

Whether new neurons contribute to human cognition in old age remains debated. Recently in Cell Stem Cell, Tosoni et al. show that immature-neuron transcriptional programs persist in the aged dentate...

cell.com
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Ketone bodies as guardians of leukemic stemness through ferroptosis suppression dlvr.it/TSvH49

Ketone bodies as guardians of leukemic stemness through ferroptosis suppression

Leukemia stem cells exploit cell-intrinsic ketogenesis to suppress ferroptosis and sustain disease propagation. In this issue, Han et al. uncover a β-hydroxybutyrate-epigenetic-lipid remodeling axis...

cell.com
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Closing the gap: Toward functional, bioengineered esophageal grafts dlvr.it/TSvDGm

Closing the gap: Toward functional, bioengineered esophageal grafts

In a recent Nature Biotechnology paper, Pablo De Coppi et al. integrate tissue engineering with organ transplantation in a porcine model. They demonstrate that microinjection of autologous myogenic...

cell.com
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Smooth muscle cells transiently acquire a CD34 progenitor state upon injury to drive pathological vascular remodeling dlvr.it/TSv40N

Smooth muscle cells transiently acquire a CD34 progenitor state upon injury to drive pathological...

Lu et al. identify a smooth muscle-derived CD34⁺ transient progenitor cell (STPC) population that emerges following vascular injury. These cells exhibit high proliferative capacity and significantly...

cell.com
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Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging dlvr.it/TStPRJ

Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory...

Walker and colleagues show that hippocampal neural precursor cells are especially vulnerable to ferroptosis-related stress. Modulating this pathway alters adult neurogenesis and spatial learning and...

cell.com
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A precision product framework for context-dependent mechanisms of MSC therapy dlvr.it/TStMTn

A precision product framework for context-dependent mechanisms of MSC therapy

Phinney argues that overcoming translational bottlenecks in MSC therapy requires abandoning the “one-size-fits-all” manufacturing paradigm. By adopting a “precision product” framework, developers can...

cell.com
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Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems dlvr.it/TStKPz

Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturat...

Zeng et al. develop human sinoatrial node-plexus assembloids integrating pacemaker and autonomic neural organoids and incorporating atrial organoids to model the neural-pacemaker-atrial conduction...

cell.com
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Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation dlvr.it/TStJHl

Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene...

Lei et al. show that base editing restores immune function in a model of familial hemophagocytic lymphohistiocytosis while revealing pronounced platform- and cell type-specific differences in...

cell.com
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A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression dlvr.it/TStGdH

A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression

Han et al. show that leukemic stem cells (LSCs) engage autonomous ketogenesis driven by FAO to produce BHB, which suppresses ferroptosis via FADS2-dependent lipid remodeling. Targeting this pathway...

cell.com
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Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML dlvr.it/TStDBL

Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML

Waclawiczek et al. describe four distinct leukemic stem cell (LSC) subtypes in acute myeloid leukemia that determine response or resistance to the BCL-2 inhibitor venetoclax. Targeting subtype-spec...

cell.com
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eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation dlvr.it/TSt8Tt

eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell...

Yamanaka and colleagues show that the non-canonical translation factor eIF4G2 preserves adult intestinal identity by supporting selective translation of chromatin regulators. Loss of eIF4G2 shifts...

cell.com
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Engineered CAR-monocytes coordinate fibrosis clearance and cardiac regeneration following myocardial infarction dlvr.it/TSt6CV

Engineered CAR-monocytes coordinate fibrosis clearance and cardiac regeneration following myocard...

Zhang and colleagues develop pCAR-Mos as a dual-function cell therapy that clears cardiac fibrosis and regenerates myocardium, offering a reversible treatment strategy for myocardial infarction with...

cell.com
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Kristen Fortney (@bioagelabs) is part of the Hallmarks of aging speaker lineup! Join us in Seville, Oct 4–6, 2026 to explore the future of aging biology. Abstracts deadline tomorrow, June 5, 2026 hubs.li/Q04k1Tvc0 @CellPressEvents #CSAging2026
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Online Now! Evolving strategies for lineage tracing: Genetic markers, synthetic barcodes, and natural variants dlvr.it/TSn429 #stemcells

Evolving strategies for lineage tracing: Genetic markers, synthetic barcodes, and natural variants

This review synthesizes three pillars of lineage tracing—genetic markers, synthetic barcodes, and natural variants—and their integration with single-cell multi-omics and spatial profiling. It...

cell.com
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Online Now! Smooth muscle cells transiently acquire a CD34 progenitor state upon injury to drive pathological vascular remodeling dlvr.it/TSkP81 #stemcells

Smooth muscle cells transiently acquire a CD34 progenitor state upon injury to drive pathological...

Lu et al. identify a smooth muscle-derived CD34⁺ transient progenitor cell (STPC) population that emerges following vascular injury. These cells exhibit high proliferative capacity and significantly...

cell.com
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