Today, @SpaceX (Nasdaq: SPCX) makes its public market debut with a $75Bn offering (pre-greenshoe) at $135 per share, marking the largest IPO in history. Congratulations to the SpaceX team. We are honored to serve as joint lead bookrunner and sole stabilization agent.

This is what engineering progress looks like. @ElectroflowTech has scaled up their lithium extraction tech over 350M× since we backed them. In 2.5 years. First photo is the founders and the initial cell. Second shows the first 100K× scale up. Last ones show the current version.

We’ve spent decades treating lithium as a heavy duty psychiatric tool. New evidence suggests it’s actually a foundational brain nutrient and that Alzheimer’s may essentially be a localized lithium deficiency. By using the Orotate salt, we can bypass plaque-induced transport blocks and restore brain levels with 1mg. I’ve been supplementing low dose (1mg/day) lithium for years. More evidence now suggests it was the right decision. Here’s why lithium is potentially beneficial and how we arrived at this decision years ago. The study unequivocally demonstrated lithium deficiency in the brains of patients with cognitive impairment, providing mechanistic evidence of its role as a driver of disease onset and progression. It validated our choice of Lithium Orotate as the optimal form of lithium supplementation for preventing and slowing the progression of dementia. Lithium has long been a foundational ingredient in my protocol, utilized in a low-nutritional dose. This was based on our comprehensive analysis of various population studies supporting its safety and potential benefits for brain health and mental well-being. Establishing a direct mechanistic link: beyond its known effects on mood and well-being, the study forged a direct and mechanistic and progressive connection between lithium brain deficiency and cognitive impairment, including Alzheimer's disease. Optimal form of lithium: the study revealed that lithium orotate, the specific form of lithium salt I have been using for years, is superior in avoiding blockage by existing plaque, thereby achieving the highest bioavailability, greatest plaque reduction, and cognitive restoration in previously lithium-deficient mice with pre-existing cognitive impairment.

The single biggest bottleneck to cheap, renewable electricity and grid storage is the raw materials. 99% of LFP battery material, used in half of all batteries, is made in China. @ElectroflowTech has pioneered a radically efficient process that Unlocks American Lithium and is the key to truly abundant, cheap, domestic clean energy. Excited to back Electroflow alongside @fiftyyears, Harpoon, and @VoyagerVC as part of our broader thesis on electrification and energy storage. Here's @albertwenger's conversation with Eric McShane (@ChEMcShane), Electroflow's co-founder and CEO:

The single biggest bottleneck to cheap, renewable electricity and grid storage is the raw materials. 99% of LFP battery material, used in half of all batteries, is made in China. @ElectroflowTech has pioneered a radically efficient process that Unlocks American Lithium and is the key to truly abundant, cheap, domestic clean energy. Excited to back Electroflow alongside @fiftyyears, Harpoon, and @VoyagerVC as part of our broader thesis on electrification and energy storage. Here's @albertwenger's conversation with Eric McShane (@ChEMcShane), Electroflow's co-founder and CEO:

Howdy X, it's us Electroflow. We take saltwater and we make LFP cathode materials. You can read about us in the Wall Street Journal 😎🙌 Link below👇 wsj.com/articles/lithium-sta…

NEWS: Tesla has revealed that in Q1 2025, they recorded one crash for every 7.44 million miles driven in which drivers were using Autopilot technology. For drivers who were not using Autopilot technology, Tesla recorded one crash for every 1.51 million miles driven. By comparison, the most recent data available from NHTSA and FHWA (from 2023) shows that in the US there was an automobile crash approximately every 702,000 miles.

I am the 3rd person in the world to receive the @Neuralink brain implant. 1st with ALS. 1st Nonverbal. I am typing this with my brain. It is my primary communication. Ask me anything! I will answer at least all verified users! Thank you @elonmusk!

This is an excellent write up by @karpathy . "Yes, sleep matters. Overall, I will say with absolute certainty that Bryan is basically right, and my sleep scores correlate strongly with the quality of work I am able to do that day. When my score is low, I lack agency, I lack courage, I lack creativity, I'm simply tired. When my sleep score is high, I can power through anything. On my best days, I can sit down and work through 14 hours and barely notice the passage of time. It's not subtle. The effects are not a function of a single day's sleep but of the accumulated sleep debt over a duration of last few days. So in other words a single bad night is usually ok. But a few in a row is bad news. And vice versa. Listen to Bryan."

"Finding the Best Sleep Tracker" Results of an experiment where I wore 4 sleep trackers every night for 2 months. TLDR Whoop >= Oura > 8Sleep >> Apple Watch AutoSleep. Link simply right here instead of in a reply because ¯\(ツ)/¯ karpathy.bearblog.dev/findin…