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ChangLabUCSF @ChangLabUcsf

Chang Lab at UCSF, human brain, speech, brain-computer-interfaces, neurosurgery

Joined August 2020
  • Tweets 155
  • Following 6
  • Followers 2,737
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New work from our lab showing the human frontal lobe receives fast, low-level speech information in parallel with early speech areas! doi.org/10.1038/s41467-025-6…

Parallel encoding of speech in human frontal and temporal lobes

Nature Communications - Whether high-order frontal lobe areas receive raw speech input in parallel with early speech areas in the temporal lobe is unclear. Here, the authors show that frontal lobe...

nature.com
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ChangLabUCSF retweeted
UCSF Neurosurgery@NeurosurgUCSF
31 Jul 2025
For more than a century, scientists thought that Broca's area coordinates the muscle movements required to speak. But new @UCSF research from @ChangLabUCSF identifies the key role that the middle precentral gyrus (mPrCG) plays in this process. @jessierliu l8r.it/ua64

Meet the Little Brain Region that Helps You Say What’s on Your Mind

Researchers discovered that a different part of the brain handles stringing sounds and words together into coherent sentences. The information could help people who have had strokes and lost the...

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Check out our latest work developing speech decoding systems that maintain their specificity to volitional speech attempts, co-led by @asilvaalex1 and @jessierliu iopscience.iop.org/article/1…

Implications of shared motor and perceptual activations on the sensorimotor cortex for neuroprost...

Implications of shared motor and perceptual activations on the sensorimotor cortex for neuroprosthetic decoding, Silva, Alexander B, Liu, Jessie R, Anderson, Vanessa R, Kurtz-Miott, Cady M, Hallinan,...

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Rather than coding specific vocal-tract movements during attempted speech, activity at these shared electrodes could be decoded into words prior to attempted speech, supporting the emerging role of the middle precentral gyrus in speech-motor planning.
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This work wouldn’t have been possible without our two amazing participants, Bravo-1 and Bravo-3, their family and caregivers, and the support of our team!
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Our latest research on the neural basis of speech-motor sequencing is now published in @NatureHumBehav! Check out this high-level explainer video and read the full paper here: nature.com/articles/s41562-0…

Speech sequencing in the human precentral gyrus

Nature Human Behaviour - Liu et al. examine the role of sustained neural activity in the planning and production of speech sequences, revealing a key role for the middle precentral gyrus.

nature.com
UCSF Neurosurgery@NeurosurgUCSF
16 Jul 2025
New in @NatureHumBehav, @jessierliu, Lingyun Zhao, PhD & @ChangLabUCSF show that the middle precentral gyrus coordinates the muscle movements required to speak, challenging the longstanding view that Broca's area controls this process: nature.com/articles/s41562-0…
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Our latest work on the neural mechanism for stopping speech production is published! See a brief summary below and the original paper linked to the post at the bottom.
Nature Human Behaviour@NatureHumBehav
3 Mar 2025
In natural conversations, people can stop speaking at any time. How? Using high-density electrocorticography, Zhao et al. find a distinct neural signal in the human premotor cortex that inhibits speech output to achieve abrupt stopping. @ChangLabUcsf nature.com/articles/s41562-0…
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Excited to share our work on developing a bilingual speech neuroprosthesis that decodes cortical activity into English and Spanish sentences in a person with paralysis. Out today in @natBME! nature.com/articles/s41551-0…

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We leveraged this finding to demonstrate transfer learning across languages. Data collected in a first language could significantly expedite training a decoder in the second language, saving time and effort for the user.
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Our models also showed stable performance without retraining for ~2 months and these results were achieved ~4 years after ECoG implantation. We hope these findings can be scaled to more patients in the near future!
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