RNA synthetic biology lab, Rice University
Joined December 2020
- Tweets 255
- Following 653
- Followers 879
- Likes 691
9 Photos and videos
Pinned Tweet
Feb 19
New paper out! Introducing SynORI: synthetic, modular origins of replication engineered from one origin to enable tunable copy number and compatibility. We co-transform 6 SynORI at once, build signal-driven copy control for multiplexed reporting, and more! nature.com/articles/s41467-0…
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Feb 23
Honored to have RNA-addressable modification(RAM) featured on the front cover of Nature Biotech. RAM is a new reporter to measure DNA uptake in complex microbial communities using a synthetic barcoding ribozyme! Awesome collaborative project with @lauren_stadler and @JoffSilberg
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Chappell Lab retweeted
18 Aug 2025
The Stadler and Chappell labs (@ChappellLab) are hiring a joint postdoc to join an NSF-funded project on isolating and engineering environmental plasmids for microbiome engineering applications! Email jc125@rice.edu and ls58@rice.edu to apply.
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18 Aug 2025
The Chappell & Stadler Labs (@lauren_stadler) are hiring a postdoc to establish innovative tools for microbiome engineering. Apply: jc125@rice.edu and ls58@rice.edu, more details below. #SynBio #PostdocJobs
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Chappell Lab retweeted
11 Jul 2025
Online now @ Cell is the yeast multicellular engineering paper from @DrFankangMeng - the fruits of his productive PhD. He developed modular synthetic biology tools to bring multicellular behaviours to yeast - adhesion, juxtacrine signalling and more. cell.com/cell/fulltext/S0092…
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Chappell Lab retweeted
6 Jun 2025
📢 ALERT ALERT 📢 #BTO's monthly newsletter has dropped! Check it out for the latest and greatest opportunities over here at #BTO!
Visit the @DARPA webpage for more info: buff.ly/5piNgIf
🫡
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Chappell Lab retweeted
8 May 2025
Excited to share our latest work on unraveling the role of a key metabolic pathway in human gut microbiome assembly and health-relevant metabolites—powered by machine learning! Led by the talented Yiyi Liu sciencedirect.com/science/ar…
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Chappell Lab retweeted
1 May 2025
It seems there are no free-living organisms known to rely exclusively on one other organism for their survival.
Until perhaps now. Check out our latest publication in @NatureMicrobiol to see how we designed an exclusive microbial reliance using GCE.
rdcu.be/ekepI
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6 Jan 2025
Genetic code expansion - meet synthetic ecology
We designed an exclusive reliance of one engineered bacterial strain on another mediated by a non-standard AA
Exclusive reliances btwn free-living organisms aren't known in nature
Work led by NSF GRFP recipient Mandy Forti
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2 Apr 2025
Nice research briefing article on our @NatureBiotech paper on recording gene transfer using ribozymes in collaboration with @lauren_stadler @JoffSilberg labs!
nature.com/articles/s41587-0…
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Chappell Lab retweeted
23 Mar 2025
Happy Sunday to all! This morning, we are excited to share Chase’s work developing a simple, scalable method to assemble 100s-1000s of custom genes from oligo pools using standard lab tools! (Small 🧵 below)
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Chappell Lab retweeted
21 Mar 2025
Happy to announce the our paper describing a new tool for tracking horizontal gene transfer using a splicing ribozyme has been published in Nature Biotechnology! Thanks to everyone on the team for their hard work
nature.com/articles/s41587-0…
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Chappell Lab retweeted
18 Mar 2025
Information storage across a microbial community using universal RNA barcoding go.nature.com/440gL5E
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Chappell Lab retweeted
18 Mar 2025
Fresh in @NatureBiotech! We developed a synthetic biology tool for tracking gene transfer in microbial communities and applied it to study plasmid hosts in a wastewater microbiome. Awesome collab with @ChappellLab & @JoffSilberg and incredible students. nature.com/articles/s41587-0…
17 Apr 2023
Thrilled to share our new preprint on using a new type of microbial memory to track horizontal gene transfer in environmental microbial communities. Amazing collaboration with @ChappellLab and @JoffSilberg labs. biorxiv.org/content/10.1101/… (1/n)
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18 Mar 2025
Check out our latest paper on using synthetic RNA memory to record gene transfer across real microbial consortia. An amazing collaborative project at Rice U between @ChappellLab, @JoffSilberg, and @lauren_stadler labs!
nature.com/articles/s41587-0…
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Chappell Lab retweeted
11 Mar 2025
Joaquin Caro Astorga's SubtiToolKit paper is published today. This cloning toolkit for Bacillus and Geobacillus was years of effort and indepedent work by @JCaroAstorga1, first in my lab and then with @erika_alden_d at the Crick. It's been a journey! sciencedirect.com/science/ar…
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Chappell Lab retweeted
21 Feb 2025
Excited to share our work in @ScienceAdvances! TLISA is a plug-and-play cell-free protein biosensor system developed by @MeganAMcSweeney. We hope this technology is a stepping stone to expand protein detection at the point-of-care! science.org/doi/10.1126/scia…
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Chappell Lab retweeted
22 Feb 2025
Title: Engineering Plasmids with Synthetic Origins of Replication biorxiv.org/content/10.1101/… #biorxiv_synbio
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22 Feb 2025
Pre-print alert: Introducing SynORI: Synthetic origins of replication for customizable and controllable plasmids! Lots of cool applications like co-maintaining six orthogonal plasmids in E. coli for a week and copy-control biosensors!
biorxiv.org/content/10.1101/…
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Chappell Lab retweeted
6 Feb 2025
We are excited to make #CRISPR accessible to high school education. 🧬 Go check out the article in @StanfordDaily to read about our frugal CRISPRkits.
#democratizingscience #scienceaccessibility
@bioe_stanford @Stanford_ChEMH @Stanford
stanforddaily.com/2025/02/03…
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