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ChristiansonLaboratory @ChristiansonLab

Biological chemist and protein crystallographer; professor and former department chair @PennChemistry; Chesapeake Bay sailor, homeport Annapolis, Maryland.

Joined December 2017
  • Tweets 1,378
  • Following 526
  • Followers 1,847
540 Photos and videos
This wouldn't be a problem if we simply read the papers that we cite. Isn't this what we all teach our students to do?? Hallucinated citations are polluting the scientific literature. What can be done? nature.com/articles/d41586-0…

Hallucinated citations are polluting the scientific literature. What can be done?

Nature - Tens of thousands of publications from 2025 might include invalid references generated by AI, a Nature analysis suggests.

nature.com
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Just out online in Annual Review of Biochemistry! Molecular Structure and Function of Zinc-Dependent Histone Deacetylases - go.shr.lc/4c3RuLx
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Sunset over @Penn after yesterday's snow showers cleared out
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Very proud of @PennChemistry senior @KristinOsika, who will give the Founders' Award Lecture on Tuesday afternoon at the 29th Enzyme Mechanisms Conference! For additional details, see her recent paper in @PNASNews, accessed more than 1000 times to date: lnkd.in/eaK4RjAM
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Congrats to former grad student Dr. Sam Eaton, who discovered that @GSK 4394835A is a reversible covalent inhibitor of PDE3B by redetermining the structure of the enzyme-inhibitor complex. pubs.acs.org/doi/10.1021/acs…
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Just out in Biochemistry – congratulations once again to former grad student Dr. Matthew Gaynes @MNG_Chem (now a postdoc at UCL @PennSAS senior @KristinOsika! pubs.acs.org/doi/10.1021/acs…
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Bella's plan for Friday night...!
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Congrats to @PennSAS senior @KristinOsika, just selected for the Founders' Award at the 29th Enzyme Mechanisms Conference! Kristin's award lecture will focus on her pioneering work with drimenol synthase, as outlined in her recent @PNASNews paper: pnas.org/doi/10.1073/pnas.25…
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After giving a lecture earlier today at the @UoMMIB in Manchester, UK, my hosts took me to the Midland Hotel, where in 1904 CS Rolls and FH Royce met to form the venerable Rolls Royce company! @rollsroycecars
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I had a delightful visit to ⁦@ITALFARMACO⁩ in Milan yesterday to discuss our mutual interests in HDACs. Their inhibitor Givinostat was recently approved for the treatment of Duchenne muscular dystrophy.
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Surprise! former grad student Dr. Sam Eaton and I re-refined the structure of the PDE3B-GSK4394835A complex [Rowley et al. (2024) J. Med. Chem. 67, 2049 (PDB 8SYC)], discovering that GSK4394835A is a reversible covalent inhibitor. See: biorxiv.org/content/10.1101/…
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Taking the water taxi from Back Creek to Annapolis City Dock to see the Sailboat Show!
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A new class of terpene synthases in giant viruses? Dr. Eli Wenger & I comment on this recent discovery at the interface of living and non-living systems [Park et al. (2025) Biochemistry 64, 3866]: A Giant Step for Terpene Biosynthesis | Biochemistry pubs.acs.org/doi/10.1021/acs…
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Congrats to Dr. Matt Gaynes @MNG_Chem for successfully defending his PhD dissertation today – Welcome to the ancient and universal company of scholars!
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I walk past this bust of Nikola Tesla every day that I give my lectures at Penn – it is located in the lobby of the David Rittenhouse Laboratories, where lecture halls used mainly for science and engineering courses are also located. @elonmusk, does this look familiar?!
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Berkeley friends, if you're around Monday at 4pm please stop by at Nico's seminar to say hello!
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Congrats to grad student Matt Gaynes @MNG_Chem & undergrad @KristinOsika for showing us how avermitilol synthase manipulates trapped water to generate a highly strained sesquiterpene alcohol! Just out on bioRxiv: biorxiv.org/content/10.1101/…
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Very proud of my better half, recognized as a 2025 Woman of Impact in Tech! Looking forward to joining Anastasia at the Women Impact Tech conference next week in NYC.
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Congrats to @PennSAS senior @KristinOsika for her poster presentation in @PennChemistry! Her first-author PNAS paper & 2 more first-author follow-up studies are summarized. Kristin is applying to grad schools now– her research accomplishments already rival those of a PhD student!
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Congrats to grad student Matt Gaynes @MNG_Chem et al. for the 2.9 Å-resolution cryoEM structure of the 63-kD cyclase in a bifunctional class II terpene synthase, plus the discovery of substrate channeling between catalytic domains! Just out on bioRxiv: biorxiv.org/content/10.1101/…
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