You can't trust doctors to know the full story today. Too much medical school propaganda. My doctor friends hate doctors, lol. Today you need other approaches based upon evidence.

A cardiologist there named Mercedes Carnethon pulled five long-running cohort studies and looked at people who developed diabetes during follow-up. She wanted to know: once you have diabetes, does your weight predict how long you live? She got data on 2,625 people who developed diabetes during the studies. Then she sorted them by what they weighed AT diagnosis. Normal-weight diabetics. Overweight or obese diabetics. Then she counted deaths. Normal-weight diabetics died at a rate of 285 per 10,000 person-years. Overweight and obese diabetics died at a rate of 152 per 10,000 person-years. The thin diabetics died at twice the rate of the fat diabetics.

my landmark post on how fat people are often healthier than thin people has landed. mattcook.substack.com/p/fat-…

Losing weight is not going to make you healthier. In fact, people who are fatter are generally healthier than thin people, and this is known as the obesity paradox. And it's been proven time after time after time. Why not focus on improving your health, and then your body will give up fat without it being a big problem?

People are remarkably stupid because they think that they'll be healthier if they lose weight. Reality is, losing weight does not make you healthier. Everybody believes that it does, but it does not. anything with a BMI under 36 and there's no reason why you cannot be perfectly healthy Losing weight makes it much more likely that you will die. It lowers overall survival except in cases of BMI over 36

If you can't afford health insurance, you should look into these health ministries in the U.S. because you can get the same as health insurance for a fraction of the normal costs. And they do pay your bills and they do take care of the things that need to be taken care of. Most people don't know about them. Look at medi-share and Christian Health Ministries, but there are many others.

Let me explain yet again. Fat people who are fit are healthier than most thin people. There are many studies that show this. The reason possibly is that fat people who are fit have a lot more muscle than thin people do. And the fat people do much better if they get type 2 diabetes or cancer. They outlive thin people. This idea of just losing fat as THE key to health is so bogus and wrong. GLP-1 drugs cause fat people to become less healthy. They lose muscle mass they may not get back. Especially if they are older.

here's how I got rid of bad daily migraine headaches. My cortisol went through the roof. My testosterone collapsed. My erections stopped working. And my headaches turned into daily migraines. I tried at least twenty different things over the years. This is what worked. open.substack.com/pub/mattco…

fat loss doesn't mean you are healthier. You can be healthy and obese. This is so common they have a name for it, the "obesity paradox." Losing weight with a dangerous drug makes you less healthy, not more healthy. GLP-1 receptor agonists mess up your gut and pancreas and increase gut endotoxin.

Fen-phen: withdrawn 1997 for heart valve damage. Sibutramine: withdrawn 2010 for cardiovascular events. Rimonabant: withdrawn 2008 for suicidality. Lorcaserin: withdrawn 2020 for cancer. Four obesity drugs. Four withdrawals. In four decades. GLP-1 drugs are in year three.

weight loss doesn't make you healthier. In many ways, fat people can be healthier than lean people. It's called the Obesity Paradox. Data suggest that metabolically healthy obesity, especially when combined with a high level of fitness, is associated with at most a minimal increase in overall risk of cardiovascular diseases and mortality In patients with established cardiovascular diseases and other chronic conditions (kidney disease, severe arthritis), those with overweight and class I obesity have a better prognosis than lean patients—the 'obesity paradox' nature.com/articles/nrendo.2…

do vegetarians live longer than meat eaters? Hint: no, they live shorter lives on average. mattcook.substack.com/p/do-v…

intermittent fasting is bad for you. mattcook.substack.com/p/inte…

Sodhi, JAMA 2023: GLP-1 drugs raise acute pancreatitis 9-fold. Kirkegård, Gastroenterology 2018: acute pancreatitis raises long-term pancreatic cancer risk roughly 7-fold. But don't worry about these drugs.

it is probable that GLP-1 receptor agonist drugs cause cancer. Thyroid and gallbladder and pancreatic cancers are already signaled in the data we already have.

No, GLP-1 drugs aren't shown to reduce cancer metastasis. The most plausible explanation is selection bias: healthier, heavier, metabolically stable cancer patients may be more likely to get GLP-1s, while frailer or already-declining patients steered toward DPP-4 inhibitors. This study is highly suspicious. An RCT would not show this result. cdn.bfldr.com/KOIHB2Q3/as/w3…

This GLP-1 cancer headline is being over sold here by breathless doctors who don't understand studies or statistics. This plays into Big Pharma's hands. The study was an observational database study comparing cancer patients who got GLP-1-type drugs with cancer patients who got DPP-4 inhibitors. The result could be driven by selection bias: healthier patients, better access to care, different diabetes severity, different obesity treatment, different tumor biology, different tumors, or differences in who gets prescribed which drug. The press release lumps together different drugs and even includes pramlintide, which is an amylin analog, not a GLP-1 receptor agonist. This is not proof of any kind whatsoever. It is interesting, that's about it. EVERY new drug looks this way, with Big Pharma marketing. It takes many years to differentiate signal from noise.

A 2025 study by Cuomo in the journal Cancer Investigation looked at colon-cancer patients and reported five-year deaths of 15.5 percent among GLP-1 users versus 37.1 percent among non-users. A two-and-a-half-fold gap. If a drug truly did that, it would be the cancer story of the century. But look closer. That benefit only showed up in the patients with a body-mass index over 35. A real anti-cancer drug effect does not switch itself on and off depending on how heavy the patient is.

You would have to treat about 67 of heart-disease patients with semaglutide for three-plus years to prevent one cardiac event. The other 66 get the drug, the cost, and the side effects — and, on that score, nothing.

who else uses Claude Code to help with writing and not write code?

This guy tried to make something in America. It's a really outstanding video. youtu.be/yw_dT1WgQQg?si=XvJK…