Physician-scientist @UWMedicine @DermatologyUW focused on advanced microscopy, keratinocyte biology, teledermatology, and genetic/autoimmune blistering disease.
Joined January 2019
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New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: insight.jci.org/articles/vie…
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Excited to be representing @SimpsonLabUW in sunny 😎 San Diego 🌴 for #ASCB2024 #CellBio2024 @ASCBiology
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Starting the migration to the other place, using handle @SimpsonLabUW …hoping to find the old #sciencetwitter and #dermtwitter crowds.
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Proud of med student Rafael Homer whose summer research project @SimpsonLabUW @DermatologyUW won 2nd place in the @uwsomwwami Wyoming site poster competition! Rafael also won a travel award to attend the Western Medical Research Conference & was chosen for an oral presentation🤩
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Exciting week @SimpsonLabUW @DermatologyUW celebrating🍾our newest paper @JCI_insight (see separate🧵). which uncovered a mechanism that drives the pathology #Grover disease and was reversed using MEK inhibitors. Special thanks to Arti for making an amazing Indian lunch buffet!
New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: insight.jci.org/articles/vie…
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Hope this will finally move the needle for severe drug reactions like SJS & TEN, nightmare consults in #dermatology. No Rx has great evidence to halt skin/mucosal sloughing that can be fatal. JAKi remains to be rigorously tested in patients/RCT but could change standard of care.
Spatial proteomics identifies JAKi as treatment for a lethal skin disease | Nature nature.com/articles/s41586-0…
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Nature research paper: Spatial proteomics identifies JAKi as treatment for a lethal skin disease go.nature.com/3A1ld7K
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This program has been an outstanding opportunity for networking with peers, receiving grant feedback, learning how to navigate the new PI path, and getting sage career advice from leading physician-scientists. 10/10 highly recommend @the_asci. Consider applying
Early-Faculty Physician-Scientists!
Nominations are open for the ASCI Young Physician-Scientist Awards.
Award Benefits include access to @JointMeeting, networking and career development opportunities.
Deadline: Oct. 23
More info: buff.ly/3XUL9ex
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New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: insight.jci.org/articles/vie…
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Finally, we reasoned the same mechanism could drive spontaneous Grover disease (ie, not drug-induced). Accordingly, we found ERK hyper-activation in Grover disease lesions and propose MEK inhibitors may be therapeutic for this idiopathic disorder lacking any FDA-approved therapy.
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Proud of all co-authors & grateful to our collaborators @umichmedicine & @PennSbdrc including @drdremchu. Thanks to @NIH_NIAMS & @FIRST_Skin for lab support and @LEOFondet for funding my effort to find shared mechanisms & treatment strategies for rare skin #blistering diseases.
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Early-Faculty Physician-Scientists!
Nominations are open for the ASCI Young Physician-Scientist Awards.
Award Benefits include access to @JointMeeting, networking and career development opportunities.
Deadline: Oct. 23
More info: buff.ly/3XUL9ex
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Great lunch @SimpsonLabUW @DermatologyUW for lots of celebrating including Arti’s birthday 🥳 More good news to share soon now that I’m out from under the cloud of this R01 submission 😮💨📝 ✅🤞
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Cory Simpson, MD, PhD, FAAD (he/him) retweeted
1 Oct 2024
I'm excited to announce that I am on the job market for tenure-track Assistant Professor positions in cell biology, with a focus on the integrated roles of keratin filaments and organelle biology!
Please feel free to reach out, share/RT🔁!
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Very proud of Akshata for representing @SimpsonLabUW @DermatologyUW at the @UWISCRM Fall Symposium. She did a great job at her 1st poster session explaining her work developing quantitative methods to assess our model of #HaileyHailey disease, a rare #skin #blistering disorder.
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Cory Simpson, MD, PhD, FAAD (he/him) retweeted
31 Aug 2024
Last day of Early Bird Registration! Can't wait to engage in transformative dialogue with skin scientist and clinicians!
31 Aug 2024
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