A feed for the blog covalentmodifiers.blogspot.c…. Discusses the covalent modification of proteins. Available on bsky and mass std don
Joined April 2017
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8 Aug 2025
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27 May 2025
Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers covalentmodifiers.blogspot.c…
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25 May 2025
Design, synthesis and biological evaluation of the activity-based probes for FGFR covalent inhibitor covalentmodifiers.blogspot.c…
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24 May 2025
Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis covalentmodifiers.blogspot.c…
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18 May 2025
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 covalentmodifiers.blogspot.c…
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16 May 2025
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine covalentmodifiers.blogspot.c…
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8 May 2025
Discovery of Carbodiimide Warheads to Selectively and Covalently Target Aspartic Acid in KRASG12D covalentmodifiers.blogspot.c…
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8 May 2025
Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads covalentmodifiers.blogspot.c…
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2 May 2025
Glecirasib, a potent and selective covalent KRAS G12C inhibitor exhibiting synergism 2 with cetuximab or SHP2 inhibitor JAB-3312 covalentmodifiers.blogspot.c…
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Covalent Modifiers retweeted
27 Apr 2025
Clinical update for zoldonrasib - Ras(on)G12D selective covalent inhibitor - dosed at 1200 mg qd po (MTD previously not reached). Generally well tolerated, 89% disease control rate for NSCLC patients, two promising case studies shared, but still very early days. #AACR25 @AACR
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27 Apr 2025
Discovery and Optimization of a Covalent AKR1C3 Inhibitor covalentmodifiers.blogspot.c…
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27 Apr 2025
DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders covalentmodifiers.blogspot.c…
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26 Apr 2025
Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors covalentmodifiers.blogspot.c…
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26 Apr 2025
Discovery and Optimization of a Covalent AKR1C3 Inhibitor covalentmodifiers.blogspot.c…
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24 Apr 2025
Discovery of RNA-Reactive Small Molecules Guides Design of Electrophilic Modules for RNA-Specific Covalent Binders covalentmodifiers.blogspot.c…
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20 Apr 2025
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria covalentmodifiers.blogspot.c…
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13 Apr 2025
Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation covalentmodifiers.blogspot.c…
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13 Apr 2025
Covalent Modification of Glutamic Acid Inspired by HaloTag Technology covalentmodifiers.blogspot.c…
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13 Apr 2025
If you'd like to follow Covalent Modifier content on LinkedIn, our "company page" is online linkedin.com/company/covalen…
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8 Apr 2025
A predictive model for thiol reactivity of N-heteroaryl α-methylene–γ-lactams—a medicinally relevant covalent reactive group covalentmodifiers.blogspot.c…
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