We're live at #ENDO2026. Today is a big day for the Crinetics team, with multiple presentations sharing new data across acromegaly and congenital adrenal hyperplasia. Here's where to find us: 🔬 Long-Term Safety and Efficacy of Once-Daily Oral Paltusotine in Combination With Cabergoline for the Treatment of Patients With Acromegaly 📅 June 14 | 12:00pm CT 📍 ENDO Expo Hall, McCormick Place West Model-Informed Atumelnant Dose Selection for a Phase 3 Study in Adult Patients With Classic Congenital Adrenal Hyperplasia 📅 June 14 | 1:45 PM 📍 Room W184ABC Once Daily Atumelnant (CRN04894) Enables Lowering of Glucocorticoid Doses With Sustained Androgen Reduction in Adults With Congenital Adrenal Hyperplasia 📅 June 14 | 2:10 PM 📍 Room W184ABC Efficacy and Safety of Once-Daily Oral Paltusotine in Patients with Acromegaly: Up to 2 years in the PATHFNDR-1 and PATHFNDR-2 Open-Label Extension Studies 📅 June 14 | 2:30pm CT 📍 Room W183BC ‘Block And Replace’ Atumelnant (CRN04894) And Physiologic Hydrocortisone Replacement Rapidly Controls Hypercortisolism In ACTH-dependent Cushing Syndrome 📅 June 14 | 3:45 PM 📍 Room W187 Follow along for more updates today. #Endocrinology #Acromegaly #CAH

Living with a complex endocrine condition is more than a physical experience. The diagnostic journey alone, often spanning years, can take a real toll on mental health, relationships, and sense of self. That's why we built Everyday Advocacy: to make sure no one has to navigate that journey alone. Whether you're newly diagnosed or years into your care, Everyday Advocacy is designed to meet you where you are with resources, community, and support. Learn more: everydayadvocacy.com/

Every day, people living with endocrine and endocrine-related conditions navigate more than their diagnosis. Read Jacqui Kirby, our Chief Corporate Affairs Officer, latest Featured Perspective on why Crinetics built Everyday Advocacy, and what it means for the patients and caregivers we serve: crinetics.com/everyday-advoc…

For many patients, advocacy happens in the everyday moments – in the conversations navigated, the symptoms managed, and the questions asked. And in those moments, having the right information, support, and connection can make all the difference. That’s why we’re proud to introduce Everyday Advocacy, our new initiative to empower patients, strengthen education, and elevate the voices of those living with endocrine diseases. Learn more: bit.ly/49DCjax

We’re looking forward to attending #ENDO2026 and contributing to the ongoing dialogue that’s shaping the future of endocrine care. We will be presenting data in acromegaly, congenital adrenal hyperplasia, and ACTH-dependent Cushing’s syndrome, underscoring our commitment to advancing understanding in areas of high unmet need. Read more: bit.ly/4uEz0Iu

This Mental Health Awareness Month, we're proud to invest in the whole person, because at Crinetics, we succeed together, and that starts with taking care of each other. From onsite fitness to a culture rooted in compassion and continuous growth, supporting our team is part of how we power what's possible for patients. Learn more about life at Crinetics: crinetics.com/careers/

Today we announced that our treatment for adults with acromegaly has received approval by the European Commission. This marks another step forward in expanding access to treatment for patients with acromegaly in Europe. Read more: bit.ly/48nj8B9 #Acromegaly #Endocrinology

Hormones play a role in nearly every system in the body, and when they’re out of balance, the effects can show up in unexpected ways. This World Hormone Day, Crinetics’ Bob Cuddihy, SVP of Medical Affairs, highlights the role of the endocrine system and common signs of imbalance. Watch to learn more: #HormoneAwareness #EndocrineHealth #Biotech

At #AACE2026, we’re contributing to the scientific exchange shaping endocrine care. Join us for an oral presentation tomorrow at 9:00am to explore thyroid management considerations in patients with acromegaly. 🗓 April 24, 2026 ⏰ 9:00 – 9:15 AM PT 📍 Room 116 #ClinicalResearch #Biotech

We’re looking forward to participating at #AACE2026 and contributing to the ongoing dialogue in endocrine care. We’ll be sharing two oral presentations at this year’s event. See below for session details and timing.

Our culture is powered by people, and more than a few four-legged coworkers 🐾 From virtual dog walls to dog-friendly offices, we love celebrating what makes our teams feel at home. Meet a few of our four-legged coworkers ⬇️ Learn more about our culture: bit.ly/3BmigiR #CompanyCulture #Biotech #Dogs #DogsatWork

Crinetics was built on the conviction that patients with underserved endocrine diseases deserve better. Crinetics cofounders Scott Struthers and Stephen Betz recently joined @PituitaryWorldNews to share what drove them to build a different kind of biotech company. Watch the full interview: youtube.com/watch?v=piyZ0_mx…

Watch Crinetics CEO and cofounder Scott Struthers sit down with leading patient advocate @talkingacromegalywithtony to discuss the everyday reality of living with acromegaly: youtube.com/watch?v=O506FJkz…

We recently announced the submission of a Marketing Authorization Application for our proposed acromegaly treatment in Brazil. Read more about this filing and our ongoing work in endocrinology: bit.ly/47OLunF #MAA #Endocrinology

For people living with Cushing’s, the path to answers isn’t always straightforward. Symptoms can vary, mental and cognitive effects are often common, and even advanced imaging may not always reveal the cause. This Cushing’s Awareness Day, we’re raising awareness of the challenges patients may face and why continued progress in endocrine care matters. We’re also proud to acknowledge the work of the Cushing’s Support & Research Foundation (CSRF), whose commitment to patient advocacy, education, and community-building helps ensure that no one navigates this journey alone. By elevating awareness and supporting patient communities, we can help drive more informed care and more connected experiences for those affected by endocrine diseases. #CushingsAwarenessDay #Health

We’re proud to share that Isabel Kalofonos, Chief Commercial Officer at Crinetics, has been named a 2026 MM M Pinnacle Awards honoree. This recognition reflects her leadership in advancing a bold vision for the future of endocrine diseases that’s grounded in innovation, global impact, and an unwavering commitment to patients. It also honors her ability to lead with clarity and purpose in moments that demand resilience from our industry. Congratulations, Isabel! #Leadership #Innovation

In celebration of National Science Day, we asked our team what science means to them. 🔬 At Crinetics, the passion and curiosity of our scientists drive the discoveries that aim to improve the lives of people living with endocrine diseases. Interested in joining our team? We’re hiring: • VP, Clinical Endocrinology • VP, Drug Safety/ Pharmacovigilance

In honor of the internet’s favorite trend, we asked our office dogs to describe themselves on LinkedIn. Swipe to see what they said ➡️ Think you’re a fit for our pack? We’re hiring: crinetics.com/careers/

We’re proud to share that a systematic literature review and network meta-analysis evaluating pharmacologic therapies in acromegaly has been accepted for publication in the Journal of Clinical Endocrinology & Metabolism. This milestone reflects our ongoing commitment to advancing scientific understanding and supporting the endocrine community.

This International Women’s Day, we’re recognizing the women who help drive mission, culture, and impact. Today, we’re proud to spotlight Adriana Cabré and her contributions to advancing our work in endocrinology. #InternationalWomensDay