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DNA-binding drugs📚 @DNAbinding

PubMed bot reporting DNA-drug and DNA-ligand binding. Maintained by @TeifLab. Also see @TF_binding_bot, @Nucleosome_Bot, @CTCF_Papers, @generegulation

Joined September 2017
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Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein-Ligand Interactions and High Selectivity dlvr.it/T1CYzc

Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein-Ligand Interactions and...

The DNA-encoded library (DEL) discovery platform has emerged as a powerful technology for hit identification in recent years. It has become one of the major parallel workstreams for small molecule...

pubmed.ncbi.nlm.nih.gov
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SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation dlvr.it/T1BlpS

SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation -...

Platinum-based chemotherapy remains one of the major choices for treatment of ovarian cancer (OC). However, primary or acquired drug resistance severely impairs their efficiency, thereby causing...

pubmed.ncbi.nlm.nih.gov
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A new small molecule DoNA binding to CAG repeat RNA dlvr.it/T1B4B1

A new small molecule DoNA binding to CAG repeat RNA - PubMed

We here report a new molecule DoNA binding to a CAG repeat RNA. DoNA is a dimer of the NA molecule that we previously reported. NA binds with high affinity to a CAG repeat DNA but not significantly...

pubmed.ncbi.nlm.nih.gov
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Unleashing the binding interaction of chrysin-Cu(II) complex with the biomacromolecular targets: further studies of cell cytotoxicity and radical scavenging properties dlvr.it/T16fYf

Unleashing the binding interaction of chrysin-Cu(II) complex with the biomacromolecular targets:...

Flavonoids are significant dietary components and have ability to coordinate with metal ions to produce novel drug discovery leads that are superior to those of the parent flavonoids. Here, in this...

pubmed.ncbi.nlm.nih.gov
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Pharmaceutical manifestation of Knoevenagel condensed metal (II) complexes through virtual, in vitro and in vivo assessments dlvr.it/T16fWV

Pharmaceutical manifestation of Knoevenagel condensed metal (II) complexes through virtual, in...

Sulphur containing compounds possess a great deal of interest due to wide range of beneficial activities towards biotic species. This work also deals with the study of biological examination of newly...

pubmed.ncbi.nlm.nih.gov
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Structures of kinetic intermediate states of HIV-1 reverse transcriptase DNA synthesis dlvr.it/T15sXK

Structures of kinetic intermediate states of HIV-1 reverse transcriptase DNA synthesis - PubMed

Reverse transcription of the retroviral single-stranded RNA into double-stranded DNA is an integral step during HIV-1 replication, and reverse transcriptase (RT) is a primary target for antiviral...

pubmed.ncbi.nlm.nih.gov
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Intrauterine arsenic exposure induces glucose metabolism disorders in adult offspring by targeting TET2-mediated DNA hydroxymethylation reprogramming of HNF4α in developing livers, an effect alleviated by ascorbic acid dlvr.it/T15Vby

Intrauterine arsenic exposure induces glucose metabolism disorders in adult offspring by targeting...

Exposure to arsenic during gestation has lasting health-related effects on the developing fetus, including an increase in the risk of metabolic disease later in life. Epigenetics is a potential...

pubmed.ncbi.nlm.nih.gov
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Applications of cryo-EM in drug development for STING dlvr.it/T13qNz

Applications of cryo-EM in drug development for STING - PubMed

STING is a critical adaptor protein in the cGAS-mediated DNA-sensing innate immune pathway. Binding of the second messenger cGAMP generated by cGAS to STING induces the high-order oligomerization and...

pubmed.ncbi.nlm.nih.gov
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Chemotherapeutic Mechanism of Action of the Synthetic Resorcinolic Methyl 3,5-dimethoxy-2-octanoylbenzoate dlvr.it/T13qN3

Chemotherapeutic Mechanism of Action of the Synthetic Resorcinolic Methyl 3,5-dimethoxy-2-octanoy...

Resorcinolic lipids are described as potential examples of selective chemotherapeutic adjuvants that can enhance the effects of cyclophosphamide (CYC) while promoting cell death without causing DNA...

pubmed.ncbi.nlm.nih.gov
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Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial dlvr.it/T12kqP

Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the...

INTRIGUE was an open-label, phase 3 study in adult patients with advanced gastrointestinal stromal tumor who had disease progression on or intolerance to imatinib and who were randomized to once-da...

pubmed.ncbi.nlm.nih.gov
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Signal-off nanozyme-based colorimetric aptasensor for sensitive detection of ampicillin using MnO2 nanoflowers and gold nanoparticles dlvr.it/T12knt

Signal-off nanozyme-based colorimetric aptasensor for sensitive detection of ampicillin using MnO2...

The combination of nanomaterials possessing distinct characteristics and the precision of aptamers facilitates the creation of biosensors that exhibit exceptional selectivity and sensitivity. In this...

pubmed.ncbi.nlm.nih.gov
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Label-Free and Real-Time Optical Detection of Affinity Binding of the Antibody on Adherent Live Cells dlvr.it/T11QyM

Label-Free and Real-Time Optical Detection of Affinity Binding of the Antibody on Adherent Live...

Oblique-incidence reflectivity difference (OIRD) is a novel real-time, label-free, and nondestructive optical detection method and exhibits encouraging application in the detection of antibody/DNA...

pubmed.ncbi.nlm.nih.gov
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Exploring the potential molecular mechanism of Gualou Guizhi decoction in the treatment of rheumatoid arthritis based on network pharmacology and molecular docking dlvr.it/T11Qy1

Exploring the potential molecular mechanism of Gualou Guizhi decoction in the treatment of rheuma...

The therapeutic effect of GGD for RA is achieved by affecting the core targets such as VEGFA, IL-1β, IL6, CXCL8, CCL2, and JUN, which together interfere with the tumor necrosis factor signaling...

pubmed.ncbi.nlm.nih.gov
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Consistency of drug-resistant mutations in plasma and peripheral blood mononuclear cells of patients with treatment-naïve and treatment-experienced HIV-1 infection dlvr.it/T10BvD
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Synthesis and antitumor activity of cyclopentane-fused anthraquinone derivatives dlvr.it/T0zbYh

Synthesis and antitumor activity of cyclopentane-fused anthraquinone derivatives - PubMed

In our pursuit of developing novel analogs of anthracyclines with enhanced antitumor efficacy and safety, we have designed a synthesis scheme for 4,11-dihydroxy-5,10-dioxocyclopenta[b]anthracene-2-...

pubmed.ncbi.nlm.nih.gov
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Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer's disease dlvr.it/T0zbXK
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Mechanisms of Endocrine Resistance in Hormone Receptor-Positive Breast Cancer dlvr.it/T0ygyG

Mechanisms of Endocrine Resistance in Hormone Receptor-Positive Breast Cancer - PubMed

Hormone receptor-positive (HR ) breast cancer (BC) accounts for approximately 70% of all breast invasive tumors. Endocrine therapy (ET) represents the standard treatment for HR BC. Most patients,...

pubmed.ncbi.nlm.nih.gov
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Computational exploration of allosteric inhibitors targeting CDK4/CDK6 proteins: a promising approach for multi-target drug development dlvr.it/T0ygy5

Computational exploration of allosteric inhibitors targeting CDK4/CDK6 proteins: a promising...

Cyclin-dependent kinases (CDKs) play a pivotal role in orchestrating the intricate regulation of the cell cycle, a fundamental process governing cell growth and division. In particular, CDK4 and CDK6...

pubmed.ncbi.nlm.nih.gov
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Recognition of human telomeric G-quadruplex DNA by 1,5-disubstituted diethyl-amido anthraquinone derivative in different ion environments causing thermal stabilization and apoptosis dlvr.it/T0ygxw

Recognition of human telomeric G-quadruplex DNA by 1,5-disubstituted diethyl-amido anthraquinone...

Ligand binding to G-quadruplex (G4) structures at human telomeric DNA ends promotes thermal stabilization, disrupting the interaction of the telomerase enzyme, which is found active in 80-85% of...

pubmed.ncbi.nlm.nih.gov
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Protein-DNA binding sites prediction based on pre-trained protein language model and contrastive learning dlvr.it/T0ygxT

Protein-DNA binding sites prediction based on pre-trained protein language model and contrastive...

Protein-DNA interaction is critical for life activities such as replication, transcription and splicing. Identifying protein-DNA binding residues is essential for modeling their interaction and...

pubmed.ncbi.nlm.nih.gov
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