@DavidBSauer profile picture
David B Sauer @DavidBSauer
Joined February 2018
  • Tweets 723
  • Following 618
  • Followers 1,176
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David B Sauer@DavidBSauer
Mar 12
Step-by-step protocol to make stable cell lines for large-scale expression of muscle-type nAChR (and other multi-subunit targets)! By the inexhaustible and tenacious @Anna_Liiiiiiii in collab of @CMS_CDG_Oxford in @MRC_WIMM and @CmdOxford cell.com/star-protocols/full…

Protocol for stable cell line production to express muscle-type nicotinic receptor

The adult muscle-type nicotinic acetylcholine receptor (AChR) is essential for neuromuscular transmission but is difficult to produce due to the requirement for coordinated subunit assembly. Here, we...

cell.com
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New publication for SLC13A5 targeting compounds! Discovery of the BI chemical probe is out now in J. Med. Chem. Great work by Andrew Quigley, Liz Carpenter, and colleagues from Oxford's @CmdOxford, @Boehringer, and @thesgconline pubs.acs.org/doi/10.1021/acs…

Discovery and Characterization of a Nonacidic Small-Molecule Inhibitor of the Sodium-Coupled...

Citrate is a key metabolic intermediate that regulates both glycolysis and lipid metabolism. While most citrate is produced in mitochondria, some is imported from the bloodstream by the SLC13 family...

pubs.acs.org
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In another case of transporters doing more than you expect: SPNS2 is a glucose importer, in addition to its S1P export activity! Wonderful collaboration with Sarah Spiegel and colleagues at VCU School of Medicine, and the team at @CmdOxford nature.com/articles/s41467-0…

SPNS2 exports sphingosine-1-phosphate and imports glucose

Nature Communications - Spinster homolog 2 (SPNS2) exports sphingosine-1- 26 phosphate (S1P) out of cells. Here, the authors show that SPNS2 has antiporter-like activity, exporting S1P while...

nature.com
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Our study of the CAT1 amino acid transporter and viral receptor is now online in @NatureComms! Led by the incredibly talented @mingda_ye, with colleagues from @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, @NDMOxford, and supported by @im2pact_project nature.com/articles/s41467-0…

Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus...

Nature Communications - Cationic amino acids are essential to protein synthesis and cellular signaling. Here, authors determine the structure of the cationic amino acid transporter 1 and determined...

nature.com
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David B Sauer retweeted
Ruben Gonzalez@rubenlgonzalez
Jan 6
New work out today in PNAS! Secondary active transporters are everywhere, but direct observation of their structural dynamics is rarely achieved. Here, we capture the real-time dynamics of a sodium-coupled dicarboxylate transporter using smFRET. 🧵⬇️ doi.org/10.1073/pnas.2500723…
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David B Sauer retweeted
Anna Li@Anna_Liiiiiiii
18 Nov 2025
Thrilled to submit another paper with Yin Yao Dong @CMS_CDG_Oxford and @DavidBSauer 🥳🥳🥳 ✍🏻✍🏻✍🏻🦠🦠🦠 (📸photo credit: Claudia Burn-Leefe)
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David B Sauer retweeted
Mingda Ye@mingda_ye
27 Oct 2025
Gluebodies for improved crystal reliability and alternative crystal forms! (also inspiring Di-Gembody for cryoEM) @CmdOxford @FrankvonDelft Now out in ACS Central Science @ACSCentSci Many thank to great supporters! @RosFrankInst @OxfordStrubi @DavidBSauer doi.org/10.1021/acscentsci.5…

Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody...

Design of modular, transferable protein assemblies has broad applicability and in structural biology could help with the ever-troublesome crystallization bottleneck, including finding robustly...

pubs.acs.org
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Closing soon! Please apply if you are interested in targeting membrane proteins with new therapeutics!
David B Sauer@DavidBSauer
13 Jun 2025
Join our group in the Centre for Medicines Discovery at Oxford Univ. @CmdOxford @UniofOxford !!!! Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa. Please RT! my.corehr.com/pls/uoxrecruit…
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Join our group in the Centre for Medicines Discovery at Oxford Univ. @CmdOxford @UniofOxford !!!! Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa. Please RT! my.corehr.com/pls/uoxrecruit…
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Ugh. In case it wasn't obvious, this account was recently hacked. (Hopefully) now resolved
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I'm far more active on the Bluesky platform, if you want to find me there bsky.app/profile/davidbsauer…
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David B Sauer retweeted
Martin Walsh OBE@MartinWalshDLS
23 Apr 2025
First keynote of the day from ⁦@DavidBSauer⁩ #bcium2025 …before coffee and chocolates from ⁦@DECTRIS_News⁩ ⁦@ccp_em⁩ ⁦@ccp4_mx⁩ ⁦@instructhub⁩
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Another year, another mess with canceled flights. 🤬 @VirginAtlantic - Flight canceled txt, but we'll automatically rebook you. - (I called after silence) We subcontracted the flight; you must sort out with @Delta
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Should I start taking boats??
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New plan: already delayed flights have no further hiccups AND fast passport control. Trying to be hopeful 😬 Gratitude to @VirginAtlantic customer serv. for coming up with a plan
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Cheeky visit to @unisabana during a family trip! Spectacular campus in the Colombian Andes Thank you @NuryOlaya2 for a great discussion and showing us around!!
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Just finished our "State of the Group" talk in lab meeting 2024 Recap - 9 papers published - 6 papers in review - 2 DPhils What's next - More papers in flight, landing soon - Expand our toolbox and biomed relevance Another year of great pride in our team!
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Two highlights of 2024 contained in one photo 😀 Titled "First CNS submission of a newborn (aged 4 days)" Alternative title "Type VERY quietly!"
First CNS submission of a newborn (aged 4 days)

ALT First CNS submission of a newborn (aged 4 days)

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I should add one great sadness of last year, losing our colleague @sagaraturi An energetic and passionate scientist gone too soon
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Now online! @Anna_Liiiiiiii fantastic work on the structure of the Human adult Muscle-type nicotinic receptor. Wonderful collab with @CMS_CDG_Oxford at the @MRC_WIMM and @CmdOxford biorxiv.org/content/10.1101/…

Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states

Muscle-type nicotinic acetylcholine receptor (AChR) is the key signalling molecule in neuromuscular junctions. Here we present the structures of full-length human adult receptors in complex with...

biorxiv.org
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And a parallel study on human muscle-type AChR by @RyanHibbs10 and colleagues!! Wonderful to see that we agree on many points, while also making distinct and novel discoveries on AChRs in myasthenia gravis biorxiv.org/content/10.1101/…

Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures

Skeletal muscle contraction is mediated by acetylcholine (ACh) binding to its ionotropic receptors (AChRs) at neuromuscular junctions. In myasthenia gravis (MG), autoantibodies target AChRs, disrup...

biorxiv.org
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