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Del Valle Lab @DelValleLab

Organic synthesis and chemical biology lab at Notre Dame... Putting the 'PEP' in peptides.

Joined June 2019
  • Tweets 94
  • Following 156
  • Followers 550
52 Photos and videos
Excited to be co-chairing the 2026 Peptides GRC along with Flo Brunel of NovoNordisk! We're looking forward to hearing from an amazing slate of speakers across #PeptideScience. Not to be missed...apply today! grc.org/chemistry-and-biolog…
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Ever wondered how intra-strand staples impact beta-sheet stability? Check out our @J_A_C_S paper on an easy method to promote peptide folding and amyloid seeding activity. Congrats to Abha and Isaac!! pubs.acs.org/doi/10.1021/jac…

Intrastrand Peptide Staples That Promote β-Sheet Folding, Self-Assembly, and Amyloid Seeding

Side chain stapling of cysteine (Cys) residues offers convenient entry into constrained peptides with enhanced bioactivity and bioavailability. Despite its widespread application in the constraint of...

pubs.acs.org
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Some recent publication news from the lab... First, congrats to @mmwright417 for her paper exploring the impact of azapeptoid residues on collagen stability, now out in Peptide Science! onlinelibrary.wiley.com/doi/…

Incorporation of Azapeptoid Residues Into Collagen

Collagen, the major structural protein in connective tissue, adopts a right-handed triple helix composed of peptide chains featuring repeating Gly-Xaa-Yaa tripeptide motifs. While the cyclic residu...

onlinelibrary.wiley.com
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Hot off the press in @NatureChemistry: Our paper on seed-competent stapled peptides that mimic the core fold of pathological tau! rdcu.be/ej4ik Huge congrats to Isaac, Ben, and collaborators in the Jiang and Vidal labs. #PeptideScience #tau nature.com/articles/s41557-0…

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Check out this Just Accepted paper from @Avraz__Anwar describing a streamlined synthesis of N-amino peptides. This general protocol will vastly accelerate studies on amide-to-hydrazide replacement in peptides. Congrats, Avraz! doi.org/10.1021/acs.joc.5c00…

Optimized Monomer-Based Synthesis of Poly-N-amino Peptides

We report an optimized protocol for the solid-phase synthesis of backbone-N-aminated peptides. Electrophilic N-amination of amino acid zwitterions provides crude α-hydrazino acids that can be used...

pubs.acs.org
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RSC Chemical Biology paper in collaboration with the Stahelin just accepted! Stapled peptides targeting the dimer interface of the Ebola virus VP40 matrix protein. Congrats to Madi, Roopashi, and collaborators in the Stahelin and Chapagain labs! doi.org/10.1039/D5CB00048C

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The fun with unnatural proline surroagtes continues... Check out our paper on stabilized aPP proteomimetics. Congrats to first author @mmwright417 and special thanks to collaborators in the Horne and Smith labs! nature.com/articles/s42004-0…

Stabilization of a miniprotein fold by an unpuckered proline surrogate

Communications Chemistry - Proline plays an important role in mediating protein folding and stability, however, the impact of noncanonical proline analogues on protein folding and stability is not...

nature.com
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Our paper on delta-heteroatom proline surrogates in collagen is now online. Congrats to Taylor, Madi, and Natalia! pubs.rsc.org/en/content/arti…

Synthesis and stability of collagen mimetic peptides featuring δ-heteroatom-substituted prolines

We describe the first investigation of collagen mimetic peptides harboring proline surrogates with heteroatoms at the δ-position. While dehydro-δ-azaproline and (N-methyl)-δ-azaproline destabilized...

pubs.rsc.org
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Congrats to @Avraz__Anwar, whose total synthesis of marformycins A&D appeared in in @JOC_OL! Special thanks to Yassin and collaborators in the @R_H_Ebright lab. doi.org/10.1021/acs.orglett.…

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Last week the lab got together to bid farewell to @b_raj12 aka Dr. "beta-bracelet". Congrats, Ben, and all the best in Chicago!
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New Acc. Chem. Res. from the lab dropped online yesterday: pubs.acs.org/doi/10.1021/acs…. Right on first author Isaac's birthday, and one day before second author Madi's birthday. Practically twinsies! Happy bday guys! 🎂
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Huge week for 5th year ⁦⁦@b_raj12⁩. Thesis defense, Dow outstanding grad student award, and birthday to boot! Congrats Ben! 🥂
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At last... we're thrilled to send our story on macrocyclic mini-tau seeds out into the world. Organic chem, protein mimicry, cryo-EM, cell function; something for everyone! Congrats to Isaac & Xueyong, and collabs from Purdue and IUSM! chemrxiv.org/engage/chemrxiv…
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Congrats to Isaac Angera for taking home a 2nd place poster award at the 2024 Peptides GRC!! Well-deserved! Stay tuned for more on his exciting foray into "mini-tau" macrocycles.
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Del Valle Lab retweeted
ChemMedChem@ChemMedChem
5 Jan 2024
#OnTheCover Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dipeptide-Modified Analogues (ChemMedChem 1/2024) (J. R. Del Valle et al.) @DelValleLab onlinelibrary.wiley.com/doi/…
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4 new group members this month! Thrilled to welcome postdoc Abha Dangi, and 1st year grad students Ana-Teresa Mendoza, Alexandre Renon, and Fadwa Kamari. Welcome to the team!
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Del Valle Lab retweeted
Avraz Anwar@Avraz__Anwar
4 Nov 2023
Had an amazing time at the Purdue University Notre Dame Symposium (PUNDS). There were so many great talks/research being done from each university. With that being said, I am honored to receive the Best Presentation Award for my talk!
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Hats off to Theo and Natalia, who passed their candidacy exams this month!👏🎉 Cake, coats, and congrats on job well done!!
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Del Valle Lab retweeted
AusPeptide@AusPeptide
19 Oct 2023
Almost the end of #AusPeptide2023 sadly! Thank you all for coming and having a great time, giving amazing presentations and presenting fantastic posters. Hope to see everyone again soon! 🇦🇺👀🧪
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Excited to share our story on cross-beta epitope mimics targeting tau propagation, out now in @J_A_C_S. Grateful to all involved on this project, and a special congrats to first author @b_raj12!! pubs.acs.org/doi/10.1021/jac…

β-Bracelets: Macrocyclic Cross-β Epitope Mimics Based on a Tau Conformational Strain

The aggregation of misfolded tau into neurotoxic fibrils is linked to the progression of Alzheimer’s disease (AD) and related tauopathies. Disease-associated conformations of filamentous tau are...

pubs.acs.org
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