Developmental Biology. Official journal of @SocDevBio publishes original research on mechanisms of development, differentiation &growth. Your #DevBio community.
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TMBIM4 affects left-right patterning via pluripotency exit during gastrulation
Loss of tmbim4 in X. tropicalis replicates the phenotypes of human congenital heart disease patients
by Nicholas Diab, Mustafa Khokha et al
sciencedirect.com/science/ar…
ALT GFP-Tmbim4 localizes to the membrane in Xenopus
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Hypothesis: Germline rejuvenation during meiosis underlies animal oogenesis
"Rejuvenated organelles are stored in the oocyte's Balbiani body; with other germ cell components they make up 'germ plasm.'"
by Allan Spradling et al
sciencedirect.com/science/ar…
ALT Polarized germline cysts are formed in Drosophila, Xenopus and mice
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Nkx2.5 triggers vascular remodeling in chicken but not in emu wing mesoderm
"Emu Nkx2.5-positive limb cells belonged to muscle, not hematoendothelial clusters"
by Ingrid Cordeiro, Mikiko Tanaka et al
sciencedirect.com/science/ar…
ALT Increased expression of Scl is detected 24 h after Nkx2.5 overexpression, which was followed by vascular changes 48 h after electroporation
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The early arrest mutant speedbump is a loss-of-function mutation in the zebrafish ortholog of wee1, required for G2 regulatory processes.
By Rachel Warga and Donald Kane
tinyurl.com/3vadyyc9
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Ketone body supplementation into a standard high-carbohydrate diet reduces fecundity, delays larval development, and may induce autophagy in Drosophila melanogaster
By Meredith Becher, Fangyi Coco Zhai, et al
tinyurl.com/3uwwbfhb
ALT Infographic comparing a ketogenic diet and ketone supplementation: therapeutic ketogenic vs standard high-carb diet with added ketones, showing impacts on cellular autophagy, body size, reduced fertility, and delayed development in fruit flies.
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Early and transient requirements for FGFR2b/1b ligands in cochlear sensory and neural cell subtype differentiation
"Inducing a dnFGFR2b ligand trap reveals novel cochlear functions for FGF3 & FGF10"
by Suzanne Mansour, Lisa Urness
sciencedirect.com/science/ar…
ALT Critical periods for FGFR2b/1b ligands in controlling cochlear epithelial and ganglion development fall between E11.5-E13.5 and E11.5-E14.5, respectively
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Early and transient requirements for FGFR2b/1b ligands in cochlear sensory and neural cell subtype differentiation
"Inducing a dnFGFR2b ligand trap reveals novel cochlear functions for FGF3 and FGF10"
by Suzanne Mansour, Lisa Urness
sciencedirect.com/science/ar…
ALT Critical periods for FGFR2b/1b ligands in controlling cochlear epithelial and ganglion development fall between E11.5-E13.5 and E11.5-E14.5, respectively
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Towards functional genetics in the European amphioxus: Efficient CRISPR/Cas9 editing reveals Ascl1/2.1 requirement for peripheral nervous system development
by Rafath Chowdhury, Agnès Roure, Sébastien Darras @RafathChowdhur1sciencedirect.com/science/ar…
ALT CRISPR/Cas9-mediated mutagenesis of Bl-Ascl1/2.1 induces a decrease of ESN in Branchiostoma lanceolatum
🚨Next DevBioConnect on the way
Developmental Biology Author webinar featuring
Dr. Diana Fulmer
@DianaBFulmer
Dr. Amber D. Ide
🗓️May 12th, 2026
⏰11 am–12 pm CST
@SocDevBio
Register here👇
docs.google.com/forms/d/e/1F…
Paper alert! 📢 Our paper, “Fog signaling is dispensable for Drosophila trachea invagination,” has been accepted in @Dev_Bio_Journal! Huge credit to first author @vishakha_v96 (now a postdoc at NIH).
A pre-proof version is here: doi.org/10.1016/j.ydbio.2026…
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#InHoxWeTrust
HOXA5-driven transcriptional program in lung development
"HOXA5 directs Fgf10, Tbx4/5, Ptch1, Bmp4 and Wnt2 expression during lung formation"
by Béatrice Frenette, Lucie Jeannotte et al
sciencedirect.com/science/ar…
ALT Detection of HOXA5 and HOXA5-FLAG proteins by immunofluorescence for E15.5 wt (B) and Hoxa5FLAG/FLAG mouse embryos (C-F)
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POGLUT2/3 mediated EGF O-glucosylation promotes separation of digits 2 and 3 by influencing fibrillin network reorganization, signaling, and cell dynamics
by Sanjiv Neupane, Bernadette Holdener et al.
sciencedirect.com/science/ar…
ALT Reduced BMP signaling in Poglut2/3 DKO limb bud development
#DBfeature#SeaUrchin🌊
Germline factors, TDRD & Piwi, colocalize with Vasa on the mitotic apparatus during the embryogenesis of the sea urchin
Spindle localization of TDRD & PIWI proteins in sea urchin embryo
by Mariana Witmer, Mamiko Yajima et al
sciencedirect.com/science/ar…