Scientists in the lab of Peter Schultz, the President and CEO of Scripps Research, and assistant professor Christian Diercks (
@DiercksLab) have developed a synthetic biology platform that accelerates evolution itself—enabling researchers to evolve proteins with useful, new properties thousands of times faster than nature, and bypassing the slow, laborious methods currently used in medicine and biotechnology.
The T7-ORACLE orthogonal system targets only plasmid DNA (small, circular pieces of genetic material), leaving the cell’s host genome untouched. It has the potential to help scientists more rapidly evolve antibodies to target specific cancers, evolve more effective therapeutic enzymes, and design proteases that target proteins involved in cancer and neurodegenerative disease.
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