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Doris Wang @DorisWangLab

Neurosurgeon, neuroscientist, human and dog mom, social media account manager for my dog. @NeurosurgUCSF

Joined October 2019
  • Tweets 807
  • Following 1,122
  • Followers 6,592
116 Photos and videos
Doris Wang retweeted
Rithvik Ramesh@RithvikRamesh6
May 5
🚶🏽‍♂️🔄 Turns are one of the biggest challenges for people with Parkinson's disease. But what does brain activity actually do during a turn in the real world? 🧠🏠 📖 Check out our new preprint to find out! medrxiv.org/content/10.64898…
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Excited to share our latest preprint, led by @RithvikRamesh6! medrxiv.org/content/10.1101/… See his excellent summary below ⬇️

At-Home Movement State Classification Using Totally Implantable Bidirectional Cortical-Basal...

Movement decoding from invasive human recordings typically relies on a distributed system employing advanced machine learning algorithms programmed into an external computer for state classification....

medrxiv.org
Rithvik Ramesh@RithvikRamesh6
26 Feb 2025
🚨NEW PREPRINT🚨 What if we could… 🏠 collect quality neural-behavioral data at home 🧠 identify naturalistic personalized brain signatures of movement state 🚶🏽‍♂️use these biomarkers to drive real-time adaptive DBS for gait disorders Our new work @DorisWangLab shows how! (1/8)
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Doris Wang retweeted
Suzanne Tharin MD PhD
@SpineTharin
31 Jan 2025
ICYMI…just realized this is available on YouTube: my presentation @CSRS_org a couple of years ago on research funding opportunities for #spine surgeons #neurosurgery #orthotwitter #mdphdlife #MedTwitter #Neuroscience youtu.be/h7yHmHlcJzg

Funding For Spine Research - Symposia 4 Part 3 - Dr. Suzzane Tharin

This video represents Part 3 of a 4 part Symposia on Cervical Spine...

youtube.com
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Thank you @WomenInNSGY for this invitation and opportunity to hear from these amazing neurosurgeon moms about their journey in parenthood!
Women In Neurosurgery (WINS)@WomenInNSGY
8 Jan 2025
HAPPENING TOMORROW: Parenthood in #neurosurgery: challenges, choices, and triumphs. Join to hear experts share their journeys with family planning and work-life balance. Be part of the conversation—register now! @DorisWangLab @strahleMD @SarahMerrillMD @JacMacDonell
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We are excited to share our preprint: Pallidal and motor cortical interactions determine gait initiation dynamics in Parkinson's disease medrxiv.org/content/10.1101/…

Pallidal and motor cortical interactions determine gait initiation dynamics in Parkinson’s disease

Gait initiation is a fundamental human task, requiring one or more anticipatory postural adjustments (APA) prior to stepping. Deviations in amplitude and timing of APAs exist in Parkinson’s disease...

medrxiv.org
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Our results provide evidence that synchronized premotor and motor cortical activities transiently couple with the globus pallidus to regulate the timing of postural responses, and local pallidal activity regulate the amplitude of postural changes during gait initiation.
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Which may explain why PD patients who have excessive pallidal beta synchronization show hypometric weight shift during gait initiation. Kudos to the entire team and lead author Jessica Bath for spearheading this study! #Parkinsons #neurophysiology #neuroscience #dbs
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Doris Wang retweeted
Mitra Afshari (she/her)@mitra_afshari
12 Dec 2024
Looking forward to Dr. Wang’s lecture TONIGHT on FUS in Movement Disorders for the TEAM virtual lecture series…what a treat to have this amazing neurosurgeon/researcher present on the cusp of reaching this milestone. Learn more about TEAM here: mailchi.mp/e94a6a9a7eb0/team…

TEAM Movement Disorders Lecture Series

mailchi.mp
Doris Wang@DorisWangLab
11 Dec 2024
100 focused ultrasound procedures done!!! Thanks to the entire amazing team and our patients! @NeurosurgUCSF @UCSFimaging @UCSFHospitals #hifu #fus #tremor
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100 focused ultrasound procedures done!!! Thanks to the entire amazing team and our patients! @NeurosurgUCSF @UCSFimaging @UCSFHospitals #hifu #fus #tremor
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Inspiring meeting about innovations and the future of DBS! Humbled to share the stage with giants and leaders of this field. Paris, je t’aime. #DBS
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We are excited to share our preprints: Modeling and Optimizing Deep Brain Stimulation to Enhance Gait in Parkinson's Disease: Personalized Treatment with Neurophysiological Insights medrxiv.org/content/10.1101/…

Modeling and Optimizing Deep Brain Stimulation to Enhance Gait in Parkinson’s Disease: Personalized...

Although high-frequency deep brain stimulation (DBS) is effective at relieving many motor symptoms of Parkinson’s disease (PD), its effects on gait can be variable and unpredictable. This is due to...

medrxiv.org
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While DBS is effective at treating many appendicular symptoms of PD, its effects on gait are variable and less predictable. Why? Because we do not have a good understanding of neurophysiology of human gait and the impact of DBS on gait.
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Kudos to postdoc Hamid Fekri Azgomi for leading this work, and to all the coauthors, and patients!
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And finally 3) we identified physiological signatures of improved gait with DBS. This work will provide a framework for how we use neurophysiology to optimize neuromodulation to treat motor (and potentially other) symptoms of Parkinson’s Disease
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Here in PD patients implanted with GPi DBS and cortical electrodes, we 1) developed a validated walking performance index to objectively measure gait metrics in PD patients 2) used a Gaussian Process Regressor to identify stimulation parameters that produce the best gait pattern
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Thank you Steve for organizing the functional neurosurgery course! So honored to be a part of this amazing group and teaching the next generation! @CUNSGY
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Truly an amazing meeting at the American Academy of Neurological Surgeons meeting at Half Moon Bay! So inspired by the leaders of this field and what we will achieve. @NeurosurgUCSF
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