Worth a tweet detailing how I accidentally triggered a massive, acute systemic reaction in both respiratory system and skin relating to the TRP receptors ... A perfect storm of a high-dose B-complex, Gochujang, and histamine. Was almost in ER if i didnt down this TRP rabbit holes before Had Korean spicy beef short rib (gochujang/capsaicin), grilled fish collar, pineapple juice, and ginger tea at a friends place for lunch today After i drove home, both of my ears started to feel an acute localized burning sensation. and diffuse, flat, pale-red mottled erythema all over my chest and arm. have mild breathing difficulty and itchy throat. it got to be something with the food but why? as i never have any allergic reaction to Korean spice food, or ginger tea/pineapple alone. The only exception this time gotta be the B-complex i took before the lunch. So quickly ask my health agent who knows all my suppl stacks, and WGS. it turned out high-dose Niacin can cause a massive prostaglandin-mediated vasodilation pair that with capsaicin (TRPV1 activation opening ion channels) and high-histamine food (fish/banana), and you get a massive vasodilatory cascade lol So B-complex delivered a heavy dose of niacin, which triggers prostaglandin-mediated flushing. Simultaneously, the fish and banana provided a potential histamine load to hit your H1 receptors, which promptly sensitized the TRPV1 channels that were already being fired up by the capsaicin in the gochujang. It was a textbook convergence of chemical and thermal sensory pathways.