Computational biologist working on breast cancer at IRCCS Ospedale San Raffaele - Milan
Joined May 2026
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TROP2 remains a key therapeutic target across tumor types, but its biology is more complex than expression alone suggests. This multi-omic study provides a broader framework to interpret TACSTD2 across cancers. Well done @NotiniGiulia and all co-authors.
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Do you know everything about Trop2? 🤔
In this pan-cancer multi-omic analysis, we explored TACSTD2 expression, regulation, and biological associations across normal tissues and tumor types.
🔗nature.com/articles/s41698-0…
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May 20
📣New work from the NeoTRIPaPDL1 trial led by @BianchiniGP out now in @Annals_Oncology!
We profiled tumor gene expression before AND during neoadjuvant chemo ± atezolizumab (ICI) in TNBC to find predictors of pCR: doi.org/10.1016/j.annonc.202…
Key findings👇 #TNBC #immunotherapy
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May 20
🗂️ All data are publicly available!
One of the largest longitudinal RNA-Seq datasets from a phase III RCT in TNBC.
📦Data: NCBI GEO GSE319641
💻 Code: github.com/mdugo/Early_GEP_N…
Validate, challenge, build on it. #OpenScience
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🙏 This would not have been possible without Fondazione Michelangelo, @FondazioneBona1, @SanRaffaeleMI, and funders @AIRC_it @BCRFcure. A special thank to all collaborators who made this work possible!
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