Structural virology, protein engineering, cryo-EM 👩🏻‍🔬 | Ph.D. Candidate in @McLellan_Lab at UT Austin
Joined November 2022
- Tweets 8
- Following 49
- Followers 28
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Photos and videos
18 Dec 2024
I'm happy to announce that our paper is now online in Cell! This study was the result of a highly collaborative effort from many scientists. Please read it here: cell.com/cell/fulltext/S0092…
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18 Dec 2024
In this paper, we engineer glycoprotein complexes from Crimean–Congo hemorrhagic fever virus, solve structures, and test immunogenicity to gain insights into how the proteins funtion in the viral life cycle and bring forth promising reagents for further vaccine design.
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18 Dec 2024
This is my first, first-author paper of my PhD and is a reminder of my growth over the last several years and the excellent training and mentorship I've received from @McLellan_Lab. Thanks to all who contributed to this work!
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Elizabeth McFadden retweeted
28 Aug 2024
We tracked a pandemic decimating beetle colonies and used cryoEM for sequencing-free discovery of the new virus that caused it. This virus is crazy; parvoviruses aren't supposed to have such structured protein-DNA interactions. We fulfilled all 4 of Koch's postulates for etiology
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Elizabeth McFadden retweeted
28 Jun 2024
Very excited to share this story about two substitutions in a sarbecovirus spike that enhance infectivity by increasing RBD availability. My first cryoEM structure was of the RsSHC014-CoV spike protein and is included in this manuscript! biorxiv.org/content/10.1101/…
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Elizabeth McFadden retweeted
13 May 2024
I've been playing around with AlphaFold3 since the server was released and, like others have noted, I'm seeing a lot of odd pathological behaviors. For instance, when given 2 copies of this particular protein ( lipids), it more or less just superimposes the structures 1/n
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Elizabeth McFadden retweeted
22 Apr 2024
Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student @Eliza4Science! biorxiv.org/cgi/content/shor…
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Elizabeth McFadden retweeted
10 Oct 2022
Great article in the @washingtonpost by @Carolynyjohnson on the development of structure-based RSV vaccines! It's an exciting time in the field given the recent positive phase III results from @GSK and @pfizer.
washingtonpost.com/health/20…
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