DNA and chromatin in situ/ Cryo-ET @IGBMC
Joined October 2018
- Tweets 434
- Following 130
- Followers 345
- Likes 866
12 Photos and videos
Pinned Tweet
Feb 10
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10…
1
12
38
6,285
Apr 13
I am not afraid to say it: this is the most fundamental advance in our understanding of chromatin structure since the zig-zag fiber model.
Using single-H1 imaging and computational modeling, we show that most H1 behaves like a liquid inside chromatin domains, rather than binding stably to nucleosomes as in the textbook model.
Congrats, @MasaAShimazoe & all contributors! 🎉 2/2
🔗science.org/doi/10.1126/scia…
2
15
156
21,941
17 Oct 2025
Generate crowded synthetic tomographic data and train your model for particle picking in real data.
Impressive work by Mohamad Harastani:
nature.com/articles/s41467-0…
2
4
193
Mikhail Eltsov retweeted
10 Jul 2025
Our new work @biorxivpreprint
🔗biorxiv.org/cgi/content/shor…
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates.
@semeigazin @katsu_s_minami @MasaAShimazoe
4
44
180
16,614
Mikhail Eltsov retweeted
2 Jul 2025
A plain language overview of our recent publication
link.growkudos.com/1e0cnguwx…
1
1
235
Mikhail Eltsov retweeted
27 Jun 2025
Straightening FSC curves biorxiv.org/content/10.1101/… #biorxiv_biophys
1
4
532
Mikhail Eltsov retweeted
25 Jun 2025
Our latest paper is out. Getting high resolution reconstruction from vitreous cryo-sections.
Johannes Elferich et al.: In situ high-resolution cryo-EM reconstructions from CEMOVIS #ElectronTomography #IntegrativeStructuralBiology #Imaging @unibern... #IUCr journals.iucr.org/paper?S205…
1
1
12
1,281
Mikhail Eltsov retweeted
26 May 2025
26 May 2025
Cryo-EM reveals open and closed Asgard chromatin assemblies biorxiv.org/content/10.1101/… #biorxiv_biophys
2
10
44
3,551
Mikhail Eltsov retweeted
14 Mar 2025
I am seeking an Assistant Professor in my lab. If you are interested, please contact me! 📩
ゲノムダイナミクス研究室で助教を公募中です。ご興味のある方はぜひご連絡ください！
RTお願いします。 🔄
日本語版👇👇👇
36
53
16,305
Mikhail Eltsov retweeted
25 Apr 2025
🧬My retrospective chromatin review is out@Proc Jpn Acad: doi.org/10.2183/pjab.101.020
Textbook models of 30-nm fibers are fading. A new paradigm: chromatin forms liquid-like domains—locally dynamic, yet globally stable at chromosome level (viscoelastic)—supporting genome function.✨
1
21
94
6,969
Mikhail Eltsov retweeted
25 Apr 2025
🎥 Video: See chromatin in action — each dot is a single nucleosome, dynamically fluctuating in a living HeLa cell (TMR-labeled, 50 ms/frame).
Original paper: science.org/doi/full/10.1126…
3
10
781
16 Apr 2025
A question for the experts: Can you recognize nucleosomes and linker DNA in this data?
Find an updated version of our manuscript in
biorxiv.org/content/10.1101/…
1
3
22
1,067
11 Sep 2024
Spectacular work!
21 Aug 2024
Excited to share our new paper @NatureComms.
bit.ly/3WUkxbJ
Single-nucleosome imaging reveals that condensins act as molecular crosslinkers, locally constraining nucleosomes to organize mitotic chromosomes. Nucleosome-nucleosome interactions constrain whole chromosomes.
2
263
15 Apr 2024
RT @valeroche: DNA gyrase captures a positive crossover prior to taking action
doi.org/10.1126/science.adl5…
@Naveen_Kumar__M @marechal_nils @Lyn…
6
Mikhail Eltsov retweeted
13 Mar 2024
_finally_ figuring out how to make more stable simulations that work well with other inputs from #GeomtryNodes.
Here 'simulating' some histones & DNA being attacked by a carcinogenic monkey head
#b3d #MolecularNodes
14
47
338
18,298
Mikhail Eltsov retweeted
1 Mar 2024
Interacting with ChatGPT
6
5
137
16,518
Mikhail Eltsov retweeted
29 Jan 2024
In our fourth edition of Welcome PhDs to IMCBio we have portraits from Théo Markezic, at the IBMC-CNRS and the GMGM and Lihua Li, at the IBMC-CNRS.
imcbio.unistra.fr/welcome-to…
3
3
500
Mikhail Eltsov retweeted
8 Jan 2024
Our PhD Call 2024 is open!
@IMC_Bio, @unistra, @ARN67IBMC, @IGBMC, @cnrs_ibmp, @InsermEst, @INSB_CNRS
To apply see here:
imcbio.unistra.fr/our-phd-ca…
6
8
859
Mikhail Eltsov retweeted
9 Jan 2024
New PhD students joined the IMCBio in 2024! We'll be introducing them to you (happily and honourably) week by week. Today: Lina Sène at @IGBMC and Navneet Yadav at @cnrs_ibmp !
imcbio.unistra.fr/welcome-to…
1
2
332