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1/8. Preprint!✨How spontaneous is spontaneous behavior?🧠🐭
We found that whole-brain fUSi signals predicted spontaneous behavior transitions seconds in advance. Inhibiting one node of this transition-prone state, the medial septum, facilitated switching!
biorxiv.org/content/10.64898…
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👁🗨We turn science into sight.
Congratulations to our Director @IOB_Roska on receiving the 2026 Future Vision Award alongside Connie Cepko & Daniel Ting. A recognition of long-term research now reaching patients.
🎬Watch the short movies: futurevisionfound.org/2026-f…
#Vision #Retina #Ophthalmology #Blindness #Neuroscience #ScienceInnovation #VisionRestoration #EyeHealth #BiomedicalResearch
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1/8. Preprint!✨How spontaneous is spontaneous behavior?🧠🐭
We found that whole-brain fUSi signals predicted spontaneous behavior transitions seconds in advance. Inhibiting one node of this transition-prone state, the medial septum, facilitated switching!
biorxiv.org/content/10.64898…
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7/8. In short:
~10 s before a spontaneous behavioral switch:
↑ decodability
↓ medial septum activity (and other regions)
Our interpretation: internal drive gradually builds up, creating a transition-prone brain state that makes switching more likely.
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8/8. This work builds on inspiring studies showing that internal states shape spontaneous behavior over long timescales.🕜
Huge thanks to co-authors, institutions, and funders for making this possible! 🙏
@yourUMG @MPIforBI DFG @EKFStiftung @MBExC_de
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Emilie Mace retweeted
Wait… localized norepinephrine transients in the awake visual cortex?!
Who would have guessed this neuromodulatory signal is that spatially precise, right where visual processing is happening. Brain state control just got a lot more local. nature.com/articles/s41592-0…
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Mar 16
1/8. New preprint!
Using fUSi in head-fixed mice🐭, we found that arousal events trigger a brain-wide wave of activity 🌊🧠.
Surprisingly, this pattern was preserved during manipulations of the locus coeruleus, pointing to a minor role for noradrenaline.
biorxiv.org/content/10.64898…
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Mar 16
8/8 Last but not least: Jose Maria is looking for a postdoc in computational neuroscience 🧠💻 Don’t miss the chance to recruit him — he comes highly recommended! 🚀
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New story: a protein engineering campaign to generate ambient light opsins. Engineering opsins has been limited by experimental throughput. We put an autopatcher on stilts, cut out the bottom, and made a custom lightpath to screen the response surface of over 1,500 opsins.
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