I am pleased to announce our latest paper.
We report results from single cell RNA and TCR sequencing, alongside spatial RNA and genome sequencing across different regions of kidney cancers:
cell.com/cancer-cell/fulltex…
Don’t miss it! Tomorrow 4.30pm UK - the amazing @carolinewatson presenting some of her incredible data on the evolutionary dynamics that occurs in the decade preceding AML Dx. ash.confex.com/ash/2021/webp…#ASH21
Delighted to share our paper
➡️Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
go.nature.com/3kUQVJy
Implications for our understanding of cancer risk and the somatic mutation theory of #ageing
🧵⬇️
Thrilled to share our paper on the mutational landscape of human somatic and germline cells @Nature. We integrated histology and genomics to explore the genetic diversity that develops within our bodies as we age.
nature.com/articles/s41586-0…
An illustrated tweetorial… [1/15]
Want to learn about clonal #evolution in our #blood as we age? Check out this exciting new preprint from @Emily_LMitchell and team. Proud to have been a (very small) part of it.
10/ By old age, we estimate that the majority of blood stem cells harbour one or more driver mutations, most of which do not increase the risk of cancer. Could these previously unknown mutations underlie the age-related decline in our blood system?