Our lab studies several facets of GI infection by two enteric viruses (#rotavirus and #norovirus) utilizing stem-cell derived organoids/ enteroids.
Joined September 2020
- Tweets 148
- Following 492
- Followers 702
- Likes 270
22 Photos and videos
Estes Lab at BCM retweeted
Congratulations, Dr. Mary Estes @EstesLab_BCM, one of the new members elected to the #AmericanAcademyofArtsandSciences! amacad.org/new-members-2026
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New in @JVirology: How does the human norovirus particle assemble?
Particle assembly is facilitated by VP2 acting as a molecular bridge. We also share intriguing features making pandemic HuNoV VP2 unique in structure and sequence. journals.asm.org/doi/10.1128…
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We are excited to share a breakthrough in #Norovirus research today! Inhibiting chemokine receptor signaling enables sustained GII.3 HuNoV replication and passaging in human intestinal enteroids, read here:
science.org/doi/10.1126/scia…
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And another one! From: @bcmhouston blogs.bcm.edu/2026/02/05/fro…
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Estes Lab at BCM retweeted
Why are #infants so vulnerable to #RSV infection? D. Nagaraj, A. Rajan @ORGAMEDLab, P Piedra, V. Avadhanula, @OrganoidDiva, @EstesLab_BCM et al found an answer. @bcmhouston @BCM_Pediatrics @BCMCME @DiscoverMag #miniNose #organoids discovermagazine.com/mini-no…
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Estes Lab at BCM retweeted
Studying human #gutBiology just got easier! The Blutt Lab, the Mancini Lab et al built a high-speed #imaging/quantification pipeline for #human intestinal #organoids—lab-grown #miniGut models. @PLOSONE tinyurl.com/y8wm4zyj @OrganoidDiva @EstesLab_BCM @BrittonTML @bcmhouston
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Estes Lab at BCM retweeted
Some human GII.4 #norovirus are better than others at infecting cells; @vijiayyar, @EstesLab_BCM, V. Prasad, R. Atmar et al found an explanation @bcmhouston @BCMDeptMedicine @PNASNews bcm.edu/news/some-human-gii-…
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1 Oct 2025
Published today!
👉 pnas.org/doi/10.1073/pnas.25…
Our study reveals diversity in how GII.4 human noroviruses enter intestinal cells by making distinct clusters on the cell surface and identifies key residues on the virus capsid mediating entry and clustering
@PNASNews @BCMFromtheLabs
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10 Jul 2025
Winnie (Ngan Fung) Li et al. reveal how macrophages mount a defense against HuNoV by phagocytosing infected cells — check out our latest findings! 👇
journals.asm.org/doi/10.1128…
@NganFungLi @bcmhouston @BCMFromtheLabs @CCoarfa @OrganoidDiva @sash_ramani
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Estes Lab at BCM retweeted
Drs. V Prasad, S Kaundal, @EstesLab_BCM et al have discovered replication hubs for #human #norovirus. @ScienceAdvances @bcmhouston #biomolecularCondensates #enteroids #PositiveRNAvirus @bcm_gihep @BCMCancerCenter @CPRITTexas bcm.edu/news/researchers-dis…
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16 Oct 2024
Check out our latest publication by Dr. Ettayebi et al. reporting new insights in HuNoV cultivation in human intestinal enteroids: journals.asm.org/doi/10.1128…
Many unique enteroids cultures were evaluated, you may find these data useful for further optimizing HuNoV cultivation!
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16 Oct 2024
@bcmhouston with support from wonderful collaborators: @allisonspeer5 @SaraDiRienzi @BrittonTML @OrganoidDiva @sash_ramani
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Estes Lab at BCM retweeted
Don't miss Dr. M Estes's @EstesLab_BCM presentation on #MiniGuts next Monday! @bcm_gihep @BCMGradSchool @BCM_MSTP @BCM_GradDiverse @bcmhouston
QBI & @GladstoneInst Infectious Disease and Human Health Seminar Series is featuring Dr. Mary Estes from Baylor College of Medicine @BCMFromtheLabs on 05/13! Tune in as she discusses "Mini-Guts: Avatars to Understand Human Intestinal Health and Disease." qbi.ucsf.edu/giviseminar-est…
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1 Feb 2024
Congratulations to Dr. Miranda Lewis who defended her dissertation and completed her PhD! 🥳
Next, she will be a postdoctoral researcher at MSKCC with Dr. Gretchen Diehl.
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Estes Lab at BCM retweeted
Gastrointestinal discomfort? S Crawford, Zheng Liu, @huntrsmith, @EstesLab_BCM et al found a new explanation for how #rotavirus makes you sick. #diarrhea @PNASNews @BCMGradSchool @CPRITTexas @NIH @bcm_gihep blogs.bcm.edu/2024/01/11/fro… via @bcmhouston
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Estes Lab at BCM retweeted
Check out our first Image of the Month of 2024! #Human intestinal #enteroids, courtesy of Drs. S. Crawford, H. Smith, @EstesLab_BCM. @bcm_gihep blogs.bcm.edu/2024/01/02/fro… via @bcmhouston
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13 Dec 2023
Check out this publication by co-authors Dr. Zheng Liu and Hunter Smith @huntrsmith and Dr. Sue Crawford!
pnas.org/doi/abs/10.1073/pna…
This shows a new pathophysiological mechanism for rotavirus (RV)-induced malabsorptive diarrhea.
@BCMfromthelabs @bcm_gihep (1/3)
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13 Dec 2023
The triacylglycerol synthesizing enzyme DGAT1 is degraded during RV infection of intestinal cells, resulting in decreased expression of key proteins involved in nutrient absorption. (2/3)
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13 Dec 2023
The loss of sucrase isomaltase, villin, NHE3, tight junction proteins (ezrin) and cell adhesion molecules (E-cadherin), leads to malabsorptive diarrhea. A similar phenotype is observed in DGAT1 knock out human intestinal organoids. (3/3)
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