An online resource for the extracellular matrix and tissue engineering research community. Part of the @STEMCELLTech Science News service.
Joined June 2010
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GIVEAWAY! ππ
Don't miss your chance to win a pair of @STEMCELLTech science socks! π§¦
To enter, sign up to receive the latest research highlights in your field delivered to your inbox with STEMCELL Science News. π
π Learn more: bit.ly/4sFyUzh
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π’ Exciting news!
@MannKindCorp has advanced its inhaled nintedanib therapy for idiopathic #PulmonaryFibrosis into Phase 2 clinical testing, aiming to improve tolerability and lung-targeted drug delivery compared with the current oral treatment.
Learn more: bit.ly/4xrv9jE
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New work shows that ZNF469 drives lung fibroblast activation and collagen production downstream of TGF-Ξ²1/SMAD3 signaling, making it a potential therapeutic target for #PulmonaryFibrosis.
ποΈ Read the @bjbms study: bit.ly/43rXWXK
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π’ New in @ScienceAdvances!
Researchers led by Drs. Karen Oegema and Arshad Desai (@oegemadesai_lab) at @UCSanDiego have uncovered a multistep mechanism by which PLK1 #phosphorylation activates centrosomal protein SPD-5 to recruit Ξ³-tubulin complexes and precisely control #microtubule nucleation during mitotic spindle assembly.
Learn more: bit.ly/4ebxgzj
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Researchers have developed a matrix metalloproteinase-responsive #hydrogel system that delivers RANKL inhibitors directly to fibrous #dysplasia lesions, reducing disease progression while minimizing systemic drug exposure. π¬
Learn more: bit.ly/4vypy9s
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This review frames stress urinary incontinence as a clinically relevant ECM-failure niche and synthesizes ECM-targeted biomaterials and nanocarriers designed to rebalance the MMP/TIMP axis while enabling pragmatic pharmacodynamic readouts for early translation.
π bit.ly/43vdn1z
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In this study, researchers investigated the role of mesangial cellβderived ECM protein 1 in regulating mesangial matrix homeostasis and glomerular structure in mice. π¬
bit.ly/436nGsF
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To modulate the oxidative microenvironment and remodel the ECM, a smart microneedle capable of regulating reactive oxygen species and delivering matrix metalloproteinase functions was developed. π
@acsnano | bit.ly/4dmgkaq
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𧫠The central mechanotransduction mechanisms through which matrix stiffness drives fibrotic progression remain poorly understood.
To investigate this, primary human corneal fibroblasts were cultured on hydrogels with varying stiffness.
@ActaBio | bit.ly/4veXwQq
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𦴠The development of artificial scaffolds capable of providing dynamically evolving mineralized niches for MSCs remains challenging.
That's why scientists developed hierarchical graphene-doped PMMA scaffolds and demonstrated its potential for regenerating critical-sized bone defects.
@Biomaterials_ | bit.ly/4dYvrWD
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Oorja Bio has reported promising Phase 1 and preclinical results for ORJ-001, a first-in-class peptide therapy for idiopathic #PulmonaryFibrosis that restores alveolar epithelial cell function and is advancing to Phase 2 trials. π
Press release: bit.ly/3Q9TM3G
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A new study from researchers in China has identified a #hypoxia-driven stromal niche in #HepatocellularCarcinoma where ADAM8βΊ macrophages and FAPβΊ fibroblasts promote extracellular matrix remodeling and are associated with poor patient outcomes.
π¬ Read the @CIR_AACR study: bit.ly/4uCozoN
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Using a patient-derived fibrotic tumor model, researchers show that stromal stiffness drives chemoresistance through YAP signaling rather than drug penetration barriers, enabling an effective sequential therapy strategy to restore #chemotherapy sensitivity.
π¬ Learn more: bit.ly/4dukzkl
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This new @ACSPublications #review highlights the potential of self-assembling extracellular matrix-mimetic #peptides as customizable, low-immunogenic scaffolds for tissue engineering, regenerative medicine, and drug delivery applications.
Learn more: bit.ly/3RxXnZN
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Join @NYASciences on June 9, 2026, for Molecular Pathways & Cellular Players in the Resolution of Organ Fibrosis - a one-day symposium exploring cellular players, multiomics insights, & new therapeutic directions in fibrosis research.
Register: bit.ly/4jS7FxQ
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The authors at @NCState investigated myocardial dECM-based fibrous scaffolds for iPSC-derived cardiomyocyte use
Coaxially electrospun nanofibers comprising a polyurethane core and a blend of polycaprolactone and myocardial dECM as the sheath were optimized.
π bit.ly/4wYDhbs
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π This study defines diabetic cardiomyopathy by the concurrent dysregulation of cardiac fuel metabolism, mitochondrial quality control, and matrix remodeling, highlighting ACSL1 and BNIP3L as therapeutic targets for diabetes-associated cardiac dysfunction.
@GenomeMedicine | bit.ly/4nFcxIx
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Investigators provided a clinically relevant framework for material design and established a closed-loop therapeutic strategy that integrates pathological signal decoding with targeted intervention, offering a approach for pathological scar treatment.
@acsnano | bit.ly/4dmgkaq
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This review examines the evolving understanding of #fibroblast biology in the context of myocardial fibrosis, emphasizing their contributions to inflammation and extracellular matrix dysregulation and their interactions with cardiomyocytes and endothelial cells.
π bit.ly/4nAKbPG
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π Check this out!
Researchers identified LRRC15 cancer-associated #fibroblasts (CAFs) as a tumor-specific CAF subset in lung cancer and proposed LRRC15 as a potential therapeutic target.
@CR_AACR | bit.ly/4uP6Biz
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A new @CR_AACR study from researchers at Peking University identifies LRRC15 cancer-associated #fibroblasts as a tumor-promoting cell population in #LungCancer and highlights it as a promising therapeutic target to enhance anti-tumor immunity.
π§Ύ Read the study: bit.ly/4uP6Biz
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