PhD Félix Machín (@MachinPhd) Laboratory Official X Account. We do science with yeast and more, especially interested in chromosome stability and cell cycle.
Joined July 2019
- Tweets 112
- Following 643
- Followers 509
- Likes 249
6 Photos and videos
Pinned Tweet
Exciting news from our lab! We’ve preprinted that the yeast protein Msc1, known for DNA repair, shifts to nucleus-vacuole junctions (NVJs) during the diauxic shift and prevents toxic NPC aggregation as cells prepare for quiescence.
Read it on bioRxiv! 👇
biorxiv.org/content/10.64898…
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Genomic Instability and Cancer Lab retweeted
🦠¿Cómo se defienden nuestras células para evitar la aparición del cáncer?
El grupo "Inestabilidad Genética y Cáncer", liderado por el Dr. Félix Machín, investiga los mecanismos de la división celular y cómo se reparan las roturas en las cadenas de ADN.
@ULL #ITB
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Genomic Instability and Cancer Lab retweeted
12 Nov 2025
Check out our latest work from @FMachinLab, published in @eLife:
“Cohesin reconstitution and homologous recombination repair of DNA double-strand breaks in late mitosis”
doi.org/10.7554/eLife.92706.…
I’d like to especially thank Dr. Lorraine Symington for her invaluable collaboration.
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Genomic Instability and Cancer Lab retweeted
10 Nov 2025
👇🏻👇🏻👇🏻
10 Nov 2025
🧩La Unidad, que en 2025 cumple 30 años como Unidad de Investigación Clínico-Experimental, ha contado para esta implementación con la colaboración de la Fundación Bioavance (@FBioavance)
➡️Más info: acortar.link/c6Vp4r
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12 Nov 2025
News! Our eLife Version of Record finally published! elifesciences.org/articles/9…
Cohesin’s kleisin subunit is back in late mitosis after DNA double-strand breaks, and…
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Genomic Instability and Cancer Lab retweeted
8 Sep 2025
También te dejamos el primer episodio en @ApplePodcasts, por si prefieres utilizar esta plataforma 🙌🏼
Episodio 1. Temporada 01. Esperanza Hernández Carralero: De la cromatina a la cerámica.
podcasts.apple.com/es/podcas…
#ciencia #podcast #podcastenespañol #science #people
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Genomic Instability and Cancer Lab retweeted
8 Sep 2025
Aquí comienza… LaPa-ciencia! 🤩.
Temporada 1. Episodio 01. Esperanza Hernández Carralero: De la cromatina a la cerámica.
Que lo disfruten👇🏼☺️
open.spotify.com/episode/5QU…
#podcast #Podcastenespañol #ciencia #science #historiasreales #people #reallife
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Delighted to announce that our latest paper is finally out in Commun Biol!
nature.com/articles/s42003-0…
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A continuation from our previous paper on iScience, we now show that Msc1 maintains nuclear envelope and nuclear pore complex integrity for DNA repair. Msc1 synergistically works with the ESCRT-III complex for this purpose, underscoring NE homeostasis as key to genome stability.
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20 May 2025
Closed mitosis is a form of cell division used by pathogenic fungi and protists. In this process, chromosomes are segregated without dismantling the nuclear envelope (NE). But what happens when they undergo mitosis with an excess of NE? Find out here! onlinelibrary.wiley.com/doi/…
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Genomic Instability and Cancer Lab retweeted
19 Mar 2025
POSTDOC position available in my group @cabimer @unisevilla . Please spread the word!
Contact: nestor.garcia@cabimer.es
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Genomic Instability and Cancer Lab retweeted
10 Jan 2025
Estoy buscando candidatos para solicitar una beca postdoctoral Juan de la Cierva para trabajar en la relación entre la envoltura nuclear y la inestabilidad del genoma. ¡Date prisa, solo queda una semana pero ya tengo mi parte preparada!
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Genomic Instability and Cancer Lab retweeted
10 Jan 2025
I am looking for candidates to apply for a Juan de la Cierva postdoctoral fellowship to work on the link between the nuclear envelope and genome instability. Rush, there is only one week left but I’ve got my part ready!
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Genomic Instability and Cancer Lab retweeted
13 Dec 2024
I am pleased to share our latest work as a result of collaborating with chemists to delve into SAR and MOA of drug candidates. This time with the small local biopharma company #CEAMED cell.com/heliyon/fulltext/S2…
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Genomic Instability and Cancer Lab retweeted
4 Nov 2024
Job alert! Se ofrece contrato de doctorado asociado a proyecto (FPI) centrado en el estudio del papel central de TDP-43 en la ELA. Buscamos personas con entusiasmo y ganas de trabajar interesadas en el estudio de mecanismos moleculares de neurodegeneración en modelos de ratón
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13 Jul 2024
After posting our recent discovery of Msc1 as a protein involved in DNA double-strand break repair in late mitosis, we now post a preprint on how Msc1 might work together with the ESCRT-III complex for this goal: biorxiv.org/content/10.1101/…
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Genomic Instability and Cancer Lab retweeted
26 Jun 2024
Glad to share our latest paper!
Msc1 is a nuclear envelope protein that reinforces DNA repair in late mitosis: iScience cell.com/iscience/fulltext/S…
... and stay tuned for more soon!
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27 Dec 2023
👇🏼
27 Dec 2023
Mañana jueves 28, a las 9.30 se celebran las XVII Jornadas de Genética de la ULL. Aquellos/as que no puedan asistir podrán seguirlas a través del siguiente enlace meet.google.com/unu-xoxt-ddc
@CienciaULL @ULL @AsociacionJINTE @PaleogenomicULL @FMachinLab @Gesalud_ULL
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24 Nov 2023
We are pleased to share with you our latest pre-print on the discovery of Msc1 as a late mitotic DNA repair factor in yeast.
biorxiv.org/content/10.1101/…
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