This work is a call for attention and effort to determine the actual redox state of enzyme-bound cofactor or cosubstrate in redox reactions! sciencedirect.com/science/ar… @UTSAChemistry @UTSASciences @jbiolchem

Hey y'all! Check out our new paper from Ephrahime and company lending understanding to L-Tyr's amino group in the His-ligated heme enzyme tyrosine hydroxylase, clarifying its catalytic role via substrate analogs @UTSAChemistry @UTSASciences @ACScatalysis pubs.acs.org/doi/10.1021/acs…

The Welch-funded project at @UTSAChemistry, led by PI Aimin Liu (@Dr_Feradical), has resulted in a new publication in the high-profile chemistry journal Angewandte Chemie. This work uncovers how the iron-containing oxindole-installation enzyme MarE shifts gears in oxygenation selectivity through structural and redox tuning, guiding distinct product outcomes from a shared substrate including the predominant dioxygenated product to the intended monooxygenated 2-oxindole scaffold for natural product biosynthesis. By revealing the true catalytic identity of MarE and delineating the roles of small-molecule effectors and loop architecture, this study advances mechanistic understanding and predictive capabilities within the oxygenase superfamily. doi.org/10.1002/anie.2025108…

New publication alert! Check out our findings on MarE chemistry and how our engineered loop-swapping between MarE (SLGGR) and TDO (GTGGS) showed the importance of its role in directing oxygenation outcomes! @angew_chem @UTSAChemistry doi.org/10.1002/anie.2025108…

Proud to celebrate Ephrahime Traore and Romie Nguyen on earning their PhDs! 🎓✨ Watching you grow as scientists has been a true privilege. You’ve tackled tough experiments, late-night writing, and endless revisions! Excited to see where science takes you next! Congratulations!

The world of enzyme catalysis is expanding! Ms Graciano & @Dr_Feradical highlight the increasing diversity of protein-derived cofactors, crucial for enzyme innovation. Read their review: doi.org/10.1039/d4cs00981a #enzyme #biocatalysis #cofactor @UTSA @NSF @NIGMS @WelchFoundation

Check out our new publication! Structural insights into 2-oxindole-forming monooxygenase MarE: Divergent architecture and substrate positioning vs. tryptophan dioxygenases sciencedirect.com/science/ar… @WelchFoundation @jbiolchem

Whoa, hey there boss! Your innovative ideas and consistent support puts your students (us!) in optimal conditions to thrive. We are very happy to see UTSA recognize your efforts! @UTSAchemistry @UTSASciences @UTSAtoday utsa.edu/today/2024/11/story…

Excited to share our new publication in JBC on the enol/keto tautomerization of oxaloacetate by ACMS decarboxylase (doi: 10.1016/j.jbc.2024.107878)! This finding highlights the need for further biological testing. #ACMSD #enzymology #Oxaloacetate #metabolism

Temperature is an important factor for pathogenic protein. See how KatG regulates its activity by an N-OOH adduct and uses its MYW cofactor to direct its oxidizing power towards peroxide decomposition rather than peroxidase activity @angew_chem @UTSA

New NIH grant! Join us to study amino acid metabolism, oxidation, crosslinking by metalloenzymes using Chem Biol, site-directed incorporation of noncanonical amino acids, spectroscopy, crystallography, and cryoEM (bit.ly/4daCqK9; contact: Feradical@utsa.edu) #ScienceJobs

We were very happy and honored to have lab alumnus Capt. Ian Davis join us for a dinner with the whole group. It was great to hear about your new work and life experiences and know that you are thriving, Ian! @GeorgiaStateU @UTSA @UTSAChemistry

The Liu lab Summer2024 pickleball competition was a great success. Our students need to work harder to improve their pickleball skills since @Dr_Feradical gave no quarter and decisively won! Can't let this happen again... @UTSAChemistry @UTSA @UTSASciences

ADO is pivotal in the regulation of oxygen sensing and thiol metabolism. We present evidence of a catalytic metal(3 )-bound superoxo intermediate, challenging the status quo of a high-valent ferryl intermediate in the thiol dioxygenase mechanism @J_A_C_S pubs.acs.org/doi/10.1021/jac…

Rest in peace, Dr. Jarzecki

Congrats Cassadee Stagliano, for passing your candidacy exam with flying colors! We're excited to hear about your future discoveries in the heme enzyme field @UTSA @UTSASciences @UTSAChemistry

Congratulations @LiuFange! Your successes are an inspiration to us!

News of our own Dr. Ian Davis, at the Diagnostic Systems Division USAMRIID: His leadership has been instrumental in developing a groundbreaking blood testing protocol, using an innovative approach to significantly improve disease surveillance capabilities mrdc.health.mil/index.cfm/me…

Check out the most recent work from Romie and how she revealed the structural rationale for the unprecedented high-spin ferric-hydroperoxo (also known as compound 0) in CYP121 bit.ly/46cFNfC. Congratulations Romie! Can’t wait to see your next new finding! @UTSASciences

Congratulations to our very own Cassadee for receiving the Abrams award which recognizes the achievement of students in their first year of the PhD program and the great promise for future accomplishments! @UTSA @UTSAChemistry @UTSASciences