Quantitative Stem Cell Dynamics lab @IRBBarcelona led by @AlejoFraticelli stem cells | hematopoiesis | lineages | epigenetic memories Account run by students

Joined December 2021
32 Photos and videos
We are still thinking about #ISCO2026 😍 It was super nice to host in Barcelona the single cell omics community! 👏 Great science and great vibes 💃
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Fraticelli Lab retweeted
🧬How do stem cells ‘think’? 👨‍🔬Tomorrow, @alejofraticelli @irbbarcelona @icreacommunity will be giving the seminar ‘Stem cells thinking: fast and slow’ as part of @hmar_research cancer series 📍Marull Room @hospitaldelmar 📅3/06 |🕑2.00 pm 👉researchmar.net/agenda/1093/ @fraticellilab
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How do lineage-biased HSC states relate to each other? check out: rdcu.be/fkASJ in @NatureCellBio Collab with @haas_lab @ChariteBerlin BIH & MDC; Thomas Höfer & Daniel Hübschmann @DKFZ @NCT_HD @hi_stem_lab 1st authors @Esther_RCorrea @FloGrunschlager & Tamar Nizharadze
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One of the most interesting studies on lineage fate plasticity I’ve seen in a while. This one is an instant must-read. Is there clonal memory? Yes of course. But the actual clonal outcome is heavily influenced by demand from the niche/feedback. (Glad our minor contribution was helpful!)
How do lineage-biased HSC states relate to each other? check out: rdcu.be/fkASJ in @NatureCellBio Collab with @haas_lab @ChariteBerlin BIH & MDC; Thomas Höfer & Daniel Hübschmann @DKFZ @NCT_HD @hi_stem_lab 1st authors @Esther_RCorrea @FloGrunschlager & Tamar Nizharadze
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🔬 We’re hiring 3 Group Leaders in Paediatric Haematologic Malignancies 🤝 @CarrerasIJC & @IRSJD_info are joining forces to launch a new translational research hub focused on paediatric blood cancers. 📝 Apply now to drive real change for young patients: careers.carrerasresearch.org… @SJDbarcelona_es @fcarreras
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Happy to celebrate the @IRBBarcelona 20th bday with such an amazing event! ☀️🫶🏻🎂
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Huge news from #EHARecon2026 in Finland! 🏆 Congrats Maria! 🥰👏 #EHA @EHA_Hematology
It was a pleasure to present for the first time my PhD project at the #EHAReCon26 in Finland. 🇫🇮 Extremely honoured to have received the best poster presentation award from the scientific committee. Really inspired and grateful to be part of such an amazing community☀️🤍
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Fantastic day hearing about all the super cool projects cooking at the @AlejoFraticelli lab. Such a creative group of people!
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New GROUP LEADER POSITION announced @IRBBarcelona !!! This one is for CHEMICAL BIOLOGY 🧪! Chemists apply👩🏻‍🔬👨🏽‍🔬🧑🏻‍🔬!!!! recruitment.irbbarcelona.org…

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Interested in single-cell lineage tracing? 🧬 Our new Review in @NatureRevGenet updates the modern toolbox for genetic tracing and clonal analysis — from synthetic barcoding to natural genomic and epigenomic variants. Glad to have contributed alongside @AlejoFraticelli 🙌
INTERESTED IN SINGLE-CELL LINEAGE TRACING? New review @NatureRevGenet from the @FraticelliLab. 🎉🎉 nature.com/articles/s41576-0… With @VictoriaParreno we tried to update the modern manual for genetic tracing and clonal analysis. ENJOY! Read link: rdcu.be/e50gy
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A nice good-morning with a new preprint from our lab!! 😍🥳 this was a real team effort💥 Hope you all enjoy the reading!
🚨 NEW @FraticelliLab PREPRINT JUST WENT LIVE biorxiv.org/content/10.64898… Here, we describe PLSTCs, Soluplus-based expansion cultures of primary mouse *Acute Myeloid Leukemia* Stem Cells. And then we use LARRY barcoding to identify drivers of leukemogenicity and drug resistance!
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The Fraticellis started 2026 with great energy! 🥳 Our lab retreat of last week was full of fun, good vibes, heartfelt moments, and crazy late-night science discussions. 👀🩷 Batteries fully recharged!🔋
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2025 was an incredibly successful year for the Fraticelli Lab! We loved celebrating it together during our xmas day—especially with some wonderful new faces joining us.🥰 We’re excited for what 2026 will bring and wish everyone happy holidays! 🎄🎅💫
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Fraticelli Lab retweeted
Outstanding PhD fellowship call OPEN for excellent students. lacaixafoundation.org/en/doc… This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels). If you’re interested in doing a PhD in our lab @IRBBarcelona, reach out!!!!
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Fraticelli Lab retweeted
In addition, the main @IRBBarcelona PhD call is open right now! 👉 General call ➡️ bit.ly/3LtzIXi 👉 IRB DRIVE call ➡️ bit.ly/4hODx5B Come work on us - several cool possible projects in immunity, cancer and aging!!! Let’s trace some cells!

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Starting the week with a postdoc less in the lab and a nice farewell sentence on our office’s board 🥲🤍 Academia is tough when it comes to goodbyes.
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Wild paper that just got presented at the @EMBO #EMBOlineage2025 meeting. Crazy stuff. Congrats to the authors for a powerful (pun intended) finding!
Inheritable 'memory' genes drive #cancer drug tolerance, but their discovery in clinical samples is a major challenge. Our new theory, moving away from Luria-Delbruck, detects them from a *single* scRNA-seq dataset! With #ArchishmanRaju led by @suvranil_1 tinyurl.com/4pef8scy
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Just wrapped up the #EMBO Lineage Tracing Workshop and we are already feeling nostalgic! Incredible science, inspiring discussions, and a spectacular location. Huge thanks to everyone who made it so special — see you again in two years! 💥
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