Explore the community behind the journal

Frontiers | Cardiovascular health assessed by life’s essential 8 in Israeli adults aged ≥65 years...

BackgroundCardiovascular disease (CVD) and cancer, leading causes of morbidity and mortality in an aging global population, share risk factors and frequently...

Frontiers | The impact of the six pillars of lifestyle medicine on the biology of skin aging

Skin aging arises from the interaction between intrinsic genetic programs and cumulative environmental and behavioral exposures collectively defined as the e...

Frontiers | The effect of metformin treatment during primary influenza infection on heterologous...

IntroductionRespiratory illnesses like influenza and SARS-CoV-2 disproportionately affect older adults, leading to severe complications and high mortality ra...

Frontiers | Resetting the epigenetic clock: cellular senescence and regenerative strategies in...

Intervertebral disc degeneration (IDD) is the leading pathological cause of low back pain, while current clinical treatments are only palliative and cannot r...

Frontiers | Editorial: Microbial influences on aging: insights from the gut microbiome

Ιs aging an inevitable process of biological decline, or can some of its trajectory be shaped by the microbial communities that inhabit the human gut? Could ...

Frontiers | Integrating evolutionary theory into a framework for the mechanistic evaluation of...

Despite decades of research into the molecular hallmarks of aging, geroscience lacks a unifying framework that both coherently integrates evolutionary accoun...

Frontiers | Effects of Kiperin Elixea, a multicomponent antioxidant supplement, on redox homeosta...

IntroductionAging is characterized by declining NAD levels, mitochondrial dysfunction and disruption of redox homeostasis. Multi-component formulations targ...

Frontiers | Acute changes in ankle dorsiflexor strength and fNIRS-Derived cortical activation...

BackgroundNeuromuscular electrical stimulation (NMES) is widely used to improve neuromuscular function, but most studies in healthy older adults have focused...

Frontiers | Senescent fibroblasts in aging and pulmonary fibrosis

Aging is a major risk factor for many chronic lung diseases, including Idiopathic Pulmonary Fibrosis (IPF), a fatal and incurable disease characterized by pr...

Frontiers | Beyond chronological age: frailty, vitality, and subjective health structured by...

BackgroundChronological age remains a dominant factor in clinical decision-making despite its limited ability to reflect individual differences in functionin...

Frontiers | Case Report: Exceptional longevity in turner syndrome

Turner Syndrome (TS), caused by complete or partial monosomy of chromosome X, is associated with increased morbidity and reduced life expectancy, largely dri...

Frontiers | Efficacy of simultaneous aerobic and cognitive training (Activ4Brain) on physical...

IntroductionThe popularity of simultaneously integrated cognitive training and exercise programs is increasingly adopted as a strategy to mitigate age-relate...

Frontiers | Coronary angiography-derived microcirculatory resistance predicts adverse cardiovascu...

BackgroundCoronary microvascular dysfunction (CMD) has been increasingly recognized as a critical determinant of adverse cardiovascular outcomes. The coronar...

Frontiers | Gender- and domain-specific effects of a 6-month multidimensional exercise program on...

BackgroundRegular physical activity supports cognitive functioning in older age, yet little is known about domain- and gender-specific adaptations following ...

Frontiers | Studying exercise-induced affect in older adults: how the circumplex model could...

Although decades of research show the health benefits of regular exercise in older adults, the affective mechanisms underlying these benefits remain poorly u...

Frontiers | Homeodynamic Rejuvenation: an adaptive framework for resetting skin aging

Skin aging reflects not only the accumulation of molecular damage, but also a progressive decline in the skin’s ability to restore equilibrium under continuo...

Frontiers | The SIRT1–p53 axis drives a ferro-aging-like program and aggravates trophoblast...

Preeclampsia (PE) is a pregnancy-specific syndrome driven by placental dysfunction, and premature placental senescence has increasingly been implicated in it...

Frontiers | The metabolic-epigenetic landscape of aging: interplay between histone acetylation,...

BackgroundThe aging epigenome is shaped by three mechanistically distinct histone post-translational modifications—acetylation, lactylation, and glycation—ea...

Frontiers | Increased neurotoxic gliosis and blood-brain barrier dysregulation in canine cognitive...

BackgroundAs Alzheimer’s Disease (AD) and related dementias (ADRD) prevalence is projected to double by 2050, the urgency for relevant models to study its pa...