Joined December 2019
- Tweets 38
- Following 178
- Followers 105
- Likes 77
25 Photos and videos
Gabriel Loewinger retweeted
18 Mar 2025
NIH researchers developed a powerful method to track how brain-behavior relationships evolve, revealing insights that standard analyses miss. This could reshape how we study neural activity in psychiatric disorders and addiction. elifesciences.org/articles/9…
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18 Mar 2025
Want to test the effect of events/behavior at every trial time-point in photometry analyses? Paper with @erjiastats, @LovingerDavid, @fpereira. “A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments.” python and R packages! 1/13
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18 Mar 2025
• We released R and Python packages and user guides. The methods can be applied to other neural data types too!
• Paper: elifesciences.org/articles/9…
• Code and user guides: github.com/gloewing/photomet… 13/13
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18 Mar 2025
FLMM finds effects obscured by standard analyses! For example, FLMM reveals effects that “wash out” when analyzed with AUCs. In published work, Cue Period AUC finds no effects because it averages over time- windows (1) and (2) that have opposing effects. 12/13
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18 Mar 2025
FLMM can disentangle components with distinct temporal dynamics. It can also be used to run analogues of standard hypothesis tests (e.g., ANOVAs, correlations) at each trial time-point. Below is an example akin to the FLMM version of a paired t-test. 11/13
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18 Mar 2025
Informally, functional random-effects allow one to model variability across animals in the signal “shape.” 10/13
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18 Mar 2025
Functional random-effects allow one to model how the dynamics of signal-covariate associations vary across animals. 9/13
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18 Mar 2025
FLMM plots can be conceptualized as pooling signal values (dF/F) at a given trial time-point (e.g., 1.7 sec) across animals and trials, correlating it with covariate(s) (e.g., Latency-to-press) and plotting the slope of the correlation. 8/13
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18 Mar 2025
FLMM outputs a coefficient estimate plot that shows how the signal–covariate association evolves across trial time-points. 7/13
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18 Mar 2025
FLMMs exploit autocorrelation to construct *joint* 95% CIs (light grey) that show time windows where effects are statistically significant (any intervals that do not contain 0). All you need to do is visually inspect! 6/13
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18 Mar 2025
FLMM combines the benefits of 1) Mixed Models to account for between-animal heterogeneity, and 2) Functional Regression to model effects at each trial time-point. 5/13
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18 Mar 2025
Solution: We propose an analysis framework based on Functional Linear Mixed Models (FLMM) that allows one to analyze signal– covariate associations at every trial time point. 4/13
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18 Mar 2025
Problem: Photometry is often applied in nested longitudinal experiments with multiple trials per session and sessions per animal. This induces correlation, missing data, etc., that can obscure effects if not accounted for statistically. 3/13
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18 Mar 2025
Problem: Common photometry analysis methods reduce detection of effects because, among other things, they average across trials and use 0 summary statistics (e.g., AUC, peak amplitude). 2/13
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Gabriel Loewinger retweeted
24 Jul 2024
I am so excited to be co-host of @onthemedia, a show that I've loved making for over 8 years. @otmbrooke and our EP Katya Rogers have been incredible mentors. Thank you to OTM's world-class producers @eloiseblondiau @mollyfication @Rebecca_CC_ @cwango_ Thanks for listening ❤️
24 Jul 2024
A note from @MicahLoewinger as we announce he is officially our co-host!! wnycstudios.org/podcasts/otm…
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Gabriel Loewinger retweeted
17 Jul 2024
Looking forward to a STELLAR #OptoGRC2024 session on interpreting neural manipulations 🧠 🌟
Featuring speakers Daniel O'Shea, @jamesgheys1, @bingbrunton, @AmitVinograd & @GLoewinger and led by Dmitry Rinberg
We can't wait to hear from this incredible line-up!
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Gabriel Loewinger retweeted
11 Mar 2024
Check out our newly published article from our group highlighting how different neurons in the PVT play distinct roles in motivated behaviors:
sciencedirect.com/science/ar…
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13 Nov 2023
Come check out my SfN talk tomorrow Monday afternoon on analyzing trial-level photometry data! I will be talking about joint work with @erjiastats, @LovingerDavid, and @fpereira related to our new pre-print biorxiv.org/content/10.1101/…
#SfN2023
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10 Nov 2023
Want to test the effect of events/behavior at every trial time-point in photometry analyses?? Pre-print w/ @erjiastats, @LovingerDavid, @fpereira: "A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments" biorxiv.org/content/10.1101/…. 1/13
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10 Nov 2023
FLMM finds effects obscured by standard analyses! For example, FLMM reveals effects that "wash out" when analyzed with AUCs. In published work, Cue Period AUC finds no effects because it averages over time-windows (1) and (2) that have opposing effects. 12/13
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10 Nov 2023
•We release a package implementing our framework. The methods can be applied to other neural data types too!
•Interested in learning more? I am giving a talk at SfN Monday 1pm in WCC-201
•Code: github.com/gloewing/photomet… 13/13
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