Setdb1 silences ERV derived cryptic enhancers to ensure proper hematopoiesis. Although transcription factors, such as PU.1, can bind to H3K9me3 heterochromatin, their activity is inhibited by Setdb1. out in PNAS: doi.org/10.1073/pnas.2409656…

H3K9me3 is not sufficient for silencing endogenous retroviruses if DNA methylation is perturbed. In Dnmt1 ko endoderm cells, IAP elements fully maintain H3K9me3, while trancriptionally active. great collaboration with @LickertHeiko out in @NatureComms rdcu.be/cVRqS

DNA sequence-dependent formation of heterochromatin nanodomains [Graeme Thorn, Christopher Clarkson, Anne Rademacher, Hulkar Mamayusupova, Gunnar Schotta, Karsten Rippe & Vladimir Teif] nature.com/articles/s41467-0… ChromHL software here: github.com/TeifLab/ChromHL Cartoon as a bonus!

Here is our Snapshot of Human Endogenous Retroviruses (HERVs) that I wrote together with @JakobssonLab for Cell (@CellCellPress). Enjoy reading here: authors.elsevier.com/a/1eS8a… - @HelmholtzMunich @Lund_Stem

G-quadruplexes are cell type-specific and associated with high transcription. Great collaboration with @RichterLabUnipd @SaraNRichter_

Morc3 silences endogenous retroviruses by enabling Daxx-mediated H3.3 incorporation. Morc3 GHKL ATPase domain dimerizes for Daxx interaction. An efficient ATPase cycle is critical for H3.3 incorporation. biorxiv.org/cgi/content/shor…

HIV infection activates ERVs to regulate antiviral gene expression. Great collaboration headed by Daniel Sauter! academic.oup.com/nar/advance…

G4 quadruplex structures are cell type specific and associate with highly expressed genes. New preprint of a collaborative project led by @SaraNRichter_ biorxiv.org/cgi/content/shor…

Ever wonder why children react differently to pathogens? Join our lab and help us find out! uni-muenchen.de/aktuelles/st…

The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties @buschraml @gschotta @FCernilogar bit.ly/30jo4CY