@GallegoLab profile picture
Gallego Lab @GallegoLab
Joined December 2016
  • Tweets 790
  • Following 566
  • Followers 684
36 Photos and videos
Pinned Tweet
Gallego Lab@GallegoLab
Jan 19
Replying to @GallegoLab
1/10 In this thread we will explain you how we put together #SPT #SMLM #cryoET #cryoCLEM #modeling to learn about the higher-order mechanism that controls constitutive exocytosis (credits to Gallego lab/Dylan Godfrey)
0:30
1
2
4
279
Gallego Lab retweeted
ann@annacb5_
Jan 26
Join this amazing team at @UPFbiomed in Barcelona for a PhD decoding fungi evolution in extreme environments❄️ Cool microscopy with even cooler people!
Gallego Lab@GallegoLab
Jan 26
Please RT🙏 Our lab opens 2 PhD positions to investigate fungi's evolution: Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi upf.edu/documents/d/biomed/b… Computational Physical Chemistry of cellular processes under extrem environments upf.edu/documents/d/biomed/p…
1
1
190
Please RT🙏 Our lab opens 2 PhD positions to investigate fungi's evolution: Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi upf.edu/documents/d/biomed/b… Computational Physical Chemistry of cellular processes under extrem environments upf.edu/documents/d/biomed/p…
29
55
4,253
Gallego Lab retweeted
Marta Puig@_martapuig
Jan 19
Amazing example of team work! Big thanks to @sasmeek, Sebas, @GallegoLab and collaborators. Are you curious about the higher-order mechanism that controls exocytosis?👇🏼
Gallego Lab@GallegoLab
Jan 19
0/10 🥳 our #exocyst paper out in @CellCellPress, led by @_martapuig, Sebas & @sasmeek in collab with @JonasRies, @carlomanzo78, @qubilab & @dynamo_cryoET #Quantitative_Cell_Biology Continuum architecture dynamics of vesicle tethering in exocytosis: cell.com/cell/fulltext/S0092…
1
4
102
0/10 🥳 our #exocyst paper out in @CellCellPress, led by @_martapuig, Sebas & @sasmeek in collab with @JonasRies, @carlomanzo78, @qubilab & @dynamo_cryoET #Quantitative_Cell_Biology Continuum architecture dynamics of vesicle tethering in exocytosis: cell.com/cell/fulltext/S0092…

Continuum architecture dynamics of vesicle tethering in exocytosis

Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18...

cell.com
2
4
13
546
more replies
9/10 The article leaves unanswered questions: How can exocyst tether vesicles at 45 nm of the membrane if its structure is 32 nm long? Why exocyst and SNAREs cohabit for 6 s? How Sec18 dismantles the ExHOS? Which is the role of metastable states and how is the transition ctrl?...
1
1
63
10/10 This was a true team effort, supported by our groups, institutions @UPFbiomed @UPFBarcelona @uvic_ucc @MaxPerutzLabs @BasqueFor funding agencies @HFSP @AgEInves SNF, collaborators, colleagues and reviewers that helped us to make it better
3
69
Nuestro grupo oferta una de estas plazas! Si estás interesado o interesada tienes más información en nuestra web gallegolab.org

Agencia Estatal de Investigación@AgEInves
10 Aug 2025
🔬¡Oportunidad para jóvenes investigadores! La convocatoria Proyectos Generación de Conocimiento (#PID) es la principal #convocatoria de investigación en España. En la PRP de 2024 se han concedido más de 3.000 ayudas y, entre ellas, se ofrecerán más de 1.000 contratos predoctorales para quienes quieran iniciar su carrera investigadora o realizar una #tesisdoctoral. En este buscador puedes encontrar una lista con detalle de los #proyectos y donde está disponible el contrato predoctoral. ➡️aei.gob.es/noticias/propuest… #FEDER #FSEPlus
2
3
410
Gallego Lab retweeted
Biomedicina BCN@the_prbb
20 May 2025
📣 New PRBB-CRG conference 📋 Transmembrane domain-assisted folding of the integrin ectodomain 🗣️ Reinhard Faessler - @MPI_Biochem   📆 May 26 - ⏰ 12:30 CET hosted by: @GallegoLab - @UPFbiomed 📍#PRBB Auditorium
1
2
239
Please RT🙌🤗 We just opened a PhD position to investigate biophysics in eukaryotes that grow in the cryosphere (glaciers, snow, Mars...)! If you like advanced imaging, evolution and quantitative biology, we are looking for you! Apply here👇 upf.edu/documents/2869130/29…

1
46
66
9,098
Interested in imaging protein suprastructures and membranes dynamics in situ? Are you "preoccupied" by the exocyst? Read our latest preprint where we time-resolved the choreography of a flexible exocyst higher-order structure and the vesicle in exocytosis biorxiv.org/content/10.1101/…

Continuum architecture dynamics of vesicle tethering in exocytosis

Essential for eukaryotic organisms, multiple copies of the exocyst complex tether each secretory vesicle to the plasma membrane (PM) in constitutive exocytosis. The exocyst higher-order structure...

biorxiv.org
1
7
23
2,729
more replies
We were surprised that after fusion the ExHOS, with a radius of 38 nm, remains stable on the plasma membrane until it is disassembled by a reaction that requires the AAA ATPase Sec18! Which is the exact mechanism involved?? Well, this is hopefully to be shown in future threads
1
1
167
This project was led by 3 amazing researchers: @_martapuig, Sebastian Ortiz and @sasmeek with tons of help from our group at @UPFbiomed and the best collaborators ever: @JonasRies, @carlomanzo78 and Daniel Castaño-Díez labs. Thank you reader! Feedback and RT appreciated
1
161
Load more