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Gates Medical Research Institute @GatesMRI

Helping the lives of people with the greatest need by combining breakthrough science and cutting-edge product development. #globalhealth

Joined July 2017
  • Tweets 625
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  • Followers 3,232
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We must address challenges like vaccine adherence and strain variation to create more effective malaria interventions. Read more on recent perspectives in the clinical development of malaria vaccines in @Nature: nature.com/articles/s41467-0…

Recent perspectives in clinical development of malaria vaccines

Nature Communications - Malaria vaccine research has progressed significantly, with RTS,S/AS01 and R21/Matrix-M receiving WHO endorsement in 2021 / 2023. These vaccines show promise, but challenges...

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Earlier this year, Uganda became the 19th country in Africa to adopt a malaria vaccine, marking the largest malaria vaccine roll-out to date. the-star.co.ke/health/2025-0…

Uganda launches largest malaria vaccination campaign to date

It adopted the R21 vaccine, which has not been introduced in Kenya's routine immunisation.

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A recent study presented at @ESCMID revealed that more than 3 million children, particularly in Southeast Asia and Africa, died from antimicrobial resistant (AMR) infections in 2022. Read more about the threat here: gavi.org/vaccineswork/more-3…

More than 3 million children died from antimicrobial resistant infections in 2022

New data highlights the urgent need to address antimicrobial resistance (AMR) in children, as drugs of last resort are increasingly used to treat them.

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New genetic studies suggest that distinct strains of malaria exist in different areas of Africa, making some intervention tactics less effective. Major challenges remain in recruiting enough scientists with the expertise to help track these strains. gavi.org/vaccineswork/qa-unl…

Q&A: Unlocking the malaria parasite’s genetic code

The genetic diversity of the malaria parasite could hold the key to malaria treatment and research in Africa.

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There is an urgent need to tackle rising rates of TB across the globe. In 2023, 8.2M people were diagnosed with TB. If proven well tolerated and efficacious, the M72/AS01E vaccine candidate could be the first new TB vaccine in 100 years.
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Read more from @GSK in this BBC StoryWorks piece. GSK, as well as @wellcometrust and @gatesfoundation, is a partner of the Phase 3 clinical trial for the M72/AS01E vaccine candidate. bbc.com/storyworks/innovatio…

Turning thet tide against tuberculosis . As the world's deadliest infectious disease surges, GSK...

Turning thet tide against tuberculosis . As the world's deadliest infectious disease surges, GSK and partners are pioneering new prevention and treatment options

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MDR-TB threatens global TB prevention, with cases highest in 15- to 19-year-olds and deaths greatest in children ages <5. Read more to better understand global trends in MDR-TB: nature.com/articles/s41390-0…

Global burden of multidrug-resistant tuberculosis in children and adolescents

Pediatric Research - Global burden of multidrug-resistant tuberculosis in children and adolescents

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TB cases among children under 15 in the @WHO European region rose to 7,500– 650 more than in 2022. Increased travel & better diagnostics play a role, but more substantial global TB funding is critical to prevent further setbacks. reuters.com/business/healthc…

WHO calls for immediate action as report shows 10% rise in child TB infections in European region

Tuberculosis infections among children in the European region rose 10% in 2023, indicating ongoing transmission and the need for immediate public health measures to control the spread, the World...

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Treatment of TB disease is complicated by the rise of antimicrobial resistance (AMR). Reads how genomic data can predict AMR, helping clinicians tailor and improve TB treatment: nature.com/articles/s41598-0…

A comparative study of antibiotic resistance patterns in Mycobacterium tuberculosis

Scientific Reports - A comparative study of antibiotic resistance patterns in Mycobacterium tuberculosis

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Tuberculosis (TB) remains a global health challenge. Our own Alemnew Dagnew led a study using Group-Based Trajectory Modeling to track TB notification patterns over time, identifying geographic clusters to strengthen intervention strategies. Read more: bmcpublichealth.biomedcentra…

Group-based trajectory modeling to describe the geographical distribution of tuberculosis notific...

BMC Public Health - Tuberculosis (TB) is a major public health problem, and understanding the geographic distribution of the disease is critical in planning and evaluating intervention strategies....

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The Phase 3 trial of the M72/AS01E tuberculosis (TB) vaccine candidate has reached full enrollment, with approx. 20,000 participants across 5 countries, a major step in this important trial. More in @statnews: statnews.com/2025/04/28/majo…

Major tuberculosis vaccine trial completes enrollment faster than expected

A closely watched clinical trial testing what could be the world’s first new tuberculosis vaccine in a century has hit its enrollment target, ahead of expectations. 

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Gates Medical Research Institute retweeted
Trevor Mundel@trevormundel
28 Apr 2025
With full enrollment of the Phase 3 clinical trial of the M72/AS01E TB vaccine candidate ahead of schedule, we're one step closer to what could be, if proven well tolerated and efficacious, the first new TB vaccine in over a century.
Gates Medical Research Institute@GatesMRI
28 Apr 2025
We're glad to announce the Phase 3 trial of the M72/AS01E TB vaccine is fully enrolled. Thanks to all our partners and trial participants, we’re closer to understanding the safety and efficacy of the candidate. A novel TB vaccine is critical to the vision of a world without TB.
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To tackle public health threats, local scientists need access to the right resources. ClinOps provides African scientists with clinical trial training to enhance research and innovation. By investing in programs like this, we can advance global health. bmcmededuc.biomedcentral.com…

Development, implementation, and evaluation of an innovative clinical trial operations training...

BMC Medical Education - Africa’s involvement in clinical trials remains very low. Although the crucial role of training initiatives in building clinical trial capacity in Africa has been...

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We're glad to announce the Phase 3 trial of the M72/AS01E TB vaccine is fully enrolled. Thanks to all our partners and trial participants, we’re closer to understanding the safety and efficacy of the candidate. A novel TB vaccine is critical to the vision of a world without TB.
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A study found resistance to the malaria drug artemisinin in Uganda. 11 out of 100 kids had repeat infections within 28 days, showing partial resistance. We must prioritize innovative solutions to tackle this rising threat. nature.com/articles/d44148-0…
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The @FDA granted Breakthrough Device Designation to @intelligenome’s CRISPR-Tuberculosis (TB) Blood Test. This test uses CRISPR tech to detect TB in blood samples, which could help with public screening and early diagnosis of TB. biospace.com/press-releases/…

IntelliGenome Receives FDA Breakthrough Device Designation for CRISPR-TB Blood Test

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The rollout of the R21/Matrix-M vaccine in Nigeria can help protect children against malaria and offers hope to families throughout the country and region. With government and community support, Nigeria is making progress against malaria. gavi.org/vaccineswork/nigeri…

Nigeria’s first malaria vaccine roll-out is greeted by an expectant population

The race to save Nigeria’s children from malaria has received a major boost with the introduction of R21/Matrix-M vaccine. Afeez Bolaji reports on the progress of the first roll-out in Kebbi and...

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After decades of research and implementation, the @WHO has officially declared Georgia malaria-free. Effective health care policies, mosquito control and treatments have led the WHO European Region to eliminate malaria for future generations. who.int/news/item/23-01-2025…

Georgia certified malaria-free by WHO

Following a nearly century-long effort, Georgia has been certified malaria-free by the World Health Organization (WHO). With today’s announcement, Georgia joins the ranks of 45 countries and 1...

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Gates Medical Research Institute retweeted
Trevor Mundel@trevormundel
24 Mar 2025
TB is the leading infectious killer but scientific breakthroughs could change that. On #WorldTBDay, I spoke with @GatesMRI CEO Patrice Matchaba about what’s ahead - from the M72 vaccine candidate to new diagnostics & drugs. Continued global collaboration is essential to #EndTB
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Today marks one year since launching the Phase 3 clinical trial of the M72/AS01E tuberculosis (TB) vaccine candidate. The trial has 54 sites in five countries.
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If shown to be well-tolerated and effective, M72/AS01E could potentially become the first vaccine to help prevent pulmonary TB in adolescents and adults, the most common form of the disease.
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