Geneticist and stem cell biologist studying epigenetics and neurodegeneration @WhiteheadInst @MIT. B.S. @Muhlenberg Ph.D. @Penn
Joined May 2021
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Pinned Tweet
2 Nov 2025
1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @WhiteheadInst @MITBiology @MIT and Dave Mooney @Harvard @wyssinstitute trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work
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Mike Gallagher retweeted
Jan 26
GLP-1R expression protects against 58 diseases but raises risk for 34 diseases and neonatal health medrxiv.org/cgi/content/shor… #medRxiv
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2 Nov 2025
1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @WhiteheadInst @MITBiology @MIT and Dave Mooney @Harvard @wyssinstitute trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work
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87,148
2 Nov 2025
20/ strangely, leaky SALL1 is not due to unwanted splicing in the absence of drug, but rather the unspliced pre-mRNA somehow escapes the nucleus and is translated in-frame to make the full-length protein. We still don't know how this works.
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2 Nov 2025
21/ in summary, this "iPSC-Xon" system overcomes critical limitations in current transgene systems in hPSC-based work, and will benefit from additional improvements. I'm on the job market and would love to bring and improve this technology to other researchers!
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