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Center for Genome Integrity @GenomeIntegrity

Welcome to the CGI! We are a multi-disciplinary scientific community dedicated to defining mechanisms of genome instability that impact human health

Joined June 2021
  • Tweets 75
  • Following 211
  • Followers 967
57 Photos and videos
Join us Friday September 19th to learn about "Structured DNA elements in BCL2 act as genomic hotspots for activation induced cytidine deaminase" from Samantha Kendrick, PhD, from University of Arkansas for Medical Sciences.
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Join us on Monday September 8th to learn more "The bright and the dark sides of DNA replication stress in cell physiology and cancer” from Kumar Somyajit, PhD, from University of Southern Denmark.
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Thank you to @SitemanCenter ,@WashUOncology ,@WashUHematology , @wusm_pathology,@WUSTLPeds, and @SLUbiochem for supporting our 4th Annual @GenomeIntegrity Retreat! A very successful event with a great group of people.
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Join us on Friday February 21st to learn more about " Life at the edge of the chromosome: surprises about the roles of telomeres in promoting genome integrity from Julia Promisel Cooper, PhD.
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Join us next Friday January 31, to learn more about Beyond BRCA: why PARP inhibitors also kill ATM-deficient cancer cells from Ross Chapman, PhD, from University of Oxford.
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Join us on Friday January 17, 2025, to learn more about “When Watson and Crick Get linked: tumorigenesis in the setting of DNA interstrand crosslink repair deficiency” from Agata Smogorzewska, MD, PhD, from Rockefeller University.
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Join us on Friday December 13, for our GMaC Seminar Series about " Regulation of MMEJ Repair" from Nausica Arnoult, PhD, from University of Colorado Boulder @ArnoultLab
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Join us on Friday October 18, for our GMaC Seminar Series to learn more about "BRCA2 Loss Drives APOBEC3A/3B Expression and Genomic Instability Under Replication Stress" from Shailja Pathania, PhD, from University of Massachusetts Boston.
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Join us on Friday September 20th, for our GMaC Seminar Series to learn more about "“When Non-Essential DNA Repair Pathways Become Essential” from Barry Sleckman,MD, PhD, from University of Alabama at Birmingham.@BarrySleckman
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Congrats the @priyanka13verma lab on their recent publication! Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCAmutant cancer cells. Check it out! nature.com/articles/s41467-0…
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Congrats the @abbygreenlab for their recent publication in EMBO- The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress. Check it out! pubmed.ncbi.nlm.nih.gov/3888…

The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress - PubMed

Mutational patterns caused by APOBEC3 cytidine deaminase activity are evident throughout human cancer genomes. In particular, the APOBEC3A family member is a potent genotoxin that causes substantial...

pubmed.ncbi.nlm.nih.gov
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Join us on Friday May 24th, for our GMaC Seminar Series to learn more about “Concentration matters: Ribosome function beyond protein synthesis” from Rachel Green, PhD, from Johns Hopkins University, HHMI.
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Join us on Friday April 19th, for our GMaC Seminar Series to learn more about "Replication initiation and genome evolution." from Julian Sale, PhD, from Division of Protein & Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology.
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Congrats to our 3rd CGI Retreat Abstract winners! Jeremy Baeten, postdoc in Daniel Link’s lab and Lilian Silva, postdoc in Susana Gonzalo’s lab! Amazing work!
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A huge thank you to CGI Retreat invited speaker Ryan Barnes (University of Kansas Medical Center) and keynote speaker Tanya Paull (University of Texas at Austin) for their amazing talks! So glad you could join us!
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Thank you to @SitemanCenter, @WashUOnc, @WashUHeme, @wusm_pathology, @WUSTLPeds, and @SLUbiochem for supporting our 3rd Annual @GenomeIntegrity Retreat! A very successful event with a great group of people
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Join us Friday March 8th, for our GMaC Seminar Series to learn more about " Selective Control of Protein Synthesis During Stress", from Gustavo M. Silva, PhD, from Duke University.
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Join us on Friday February 16th, for our GMaC Seminar Series to learn more about “ACT-IN on a hunch when it comes to identifying novel DNA double-strand break repair disorders”, from Grant Stewart, PhD, from University of Birmingham.
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Join us on Friday January 19, for our GMaC Seminar Series to learn more about “Mining for Gold with AlphaFold: Lessons from Genome Maintenance” from Johannes Walter, PhD, from Harvard University and HHMI.
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Join us on Friday January 12, for our GMaC Seminar to learn more about “New insights into regulation of the genomic mutators APOBEC3A and APOBEC3B in normal and cancerous epithelia." from Tim Fenton, PhD, from University of Southhampton.
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