C-H bonds, peptides, carbohydrates
Joined April 2018
- Tweets 66
- Following 747
- Followers 1,455
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9 Photos and videos
10 Nov 2025
We turned a triazole ring into a molecular mousetrap—snapping up amino groups for bioconjugation! 🧠💥
Super reactive, highly selective, and thiol-tolerant.
Great teamwork with Huadong Xu (Changzhou University)!
10 Nov 2025
Snap-Trapping Strategy for Amine-Specific Bioconjugation with Pyridotriazole Carbaldehydes | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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10 Jun 2025
We’ve been dreaming of this type of conjugation chemistry for years—and finally, a simple fix to a stubborn problem, all thanks to just a tiny drop of CS₂. Minimalist chemistry is the new gold. ✨
10 Jun 2025
@gongchenlab have been hunting for ways to crosslink two different amines for conjugation: turns out that just a drop of CS₂ in air delivers great results! Read on in their Research Article: • onlinelibrary.wiley.com/doi/…
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20 Sep 2024
A huge thank you to our amazing guest editors, Masayuki Inoue, Lara Malins @Malins_lab, and Hans Renata @hanzyduzit, for organizing this OL special issue on radical-mediated reactions! Special thanks to Steve Ritter and Matt Saucier for your invaluable support.
20 Sep 2024
Special Issue alert! 🚨 This one is truly •radical•
pubs.acs.org/page/orlef7/vsi…
This VSI highlights the state of the art in radical reaction development and the strategic incorporation of radical reactions in the construction and modification of important molecules.
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10 Mar 2024
Interested in sulfonium ylide chemistry? Don’t miss Biao Xiong's latest Organic Letters paper @JOC_OL on a sleek Cu-catalyzed [3 2] route to 5-CF3-pyrroles, starting from CF3-imidoyl sulfonium ylides and terminal alkynes.
10 Mar 2024
Copper-Mediated Cyclization Gives 5-Trifluoromethylpyrroles:
Practical approach uses CF3-imidoyl sulfoxonium ylides and terminal alkynes
chemistryviews.org/copper-me…
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8 Mar 2024
HFIP's magic shines again, enabling peptide stapling with alpha-ketoaldehydes through unique imidazolium linkers, outperforming natural “glycation” processes. We proposed HFIP aggregates act as a proton shuttle for efficient deacylative C--C cleavage.
8 Mar 2024
Peptide Stapling by Crosslinking Two Amines with alpha-Ketoaldehydes through Diverse Modified Glyoxal-Lysine Dimer Linkers (Gong Chen and co-workers) @NKU1919 onlinelibrary.wiley.com/doi/…
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1 Mar 2024
We are grateful for the swift publication of this work in @NatureSynthesis and the outstanding editorial assistance received!
1 Mar 2024
N-glycoside synthesis, a tough nut to crack, is now approachable with our new light/Cu catalysis method, allowing N-glycosidic bond formation under mild conditions with exceptional water tolerance and unique chemoselectivity. Another fruitful collaboration with MJ Koh @MJKoh87.
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1 Mar 2024
N-glycoside synthesis, a tough nut to crack, is now approachable with our new light/Cu catalysis method, allowing N-glycosidic bond formation under mild conditions with exceptional water tolerance and unique chemoselectivity. Another fruitful collaboration with MJ Koh @MJKoh87.
1 Mar 2024
Now online:
Article by @MJKoh87 @GongChenLab and co-workers @NKU1919 @ChemNUS
N-glycoside synthesis through combined copper- and photoredox-catalysed N-glycosylation of N-nucleophiles
nature.com/articles/s44160-0… ($)
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27 Feb 2024
Two simple reagents, HCHO and hexafluoroisopropanol (HFIP), unleash new chemical magic! HCHO effectively “sucks” the alpha C-H bond from common alkyl amines in HFIP solvent, enabling hydride liberation without metals or light. It works for complex systems, too.
27 Feb 2024
Formaldehyde-Mediated Hydride Liberation of Alkylamines for Intermolecular Reactions in Hexafluoroisopropanol
@J_A_C_S #Chemistry #Chemed #Science
pubs.acs.org/doi/10.1021/jac…
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29 Nov 2022
I am deeply humbled and honored to be part of the editor team of Organic Letters. I very much look forward to serving the journal and our organic community☺️
28 Nov 2022
We are thrilled to announce that Prof. Gong Chen of Nankai University will be joining #OrgLett as an Associate Editor on December 1. Known for his work on metal-catalyzed C-H functionalization and on peptides and oligosaccharides, Gong may soon be handling your manuscript!
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2 Jun 2022
Our lucky streak continued! Formaldehyde can glue amine and guanidine together like a charm :) Thank Xiaosong Xue at Nankai and SIOC for the computational collaboration! pubs.acs.org/doi/10.1021/jac…
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Gong Chen retweeted
6 May 2022
Learn more about #Asymmetric C–H Functionalization in our Thieme Web #Cheminar with Joanna Wencel-Delord (@DelordWencel), Shigeki Matsunaga, Nicolai Cramer, and Bing-Feng Shi (@bfshi). Chaired by Liu-Zhu Gong and Gong Chen (@GongChenLab). Register now 👉📝fal.cn/3onTo
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17 Feb 2022
It is a great pleasure to be part of this exciting work on Fe-catalyzed C-glycoside synthesis led by MJ Koh @MJKoh87
17 Feb 2022
Happy to share our latest work in @NatureSynthesis in collaboration with @GongChenLab. We report a method to synthesize a range of C-glycosides under reductive iron catalysis. @ChemNUS @ResearchFos nature.com/articles/s44160-0…
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Extendable stapling of unprotected peptides by crosslinking two amines with o-phthalaldehyde disq.us/t/44d05fd
Our new chemistry for peptide macrocycles publishend on @NatureComms. Many thanks and Congrats @GongChenLab.
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7 Aug 2021
Please check out this work if you are interested in C-glycoside synthesis. The next goal will be alkyl C-H glycosylation :)
6 Aug 2021
Stereoselective Synthesis of C-Vinyl Glycosides via Palladium-Catalyzed C-H Glycosylation of Alkenes (Chen) onlinelibrary.wiley.com/doi/…
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22 Jul 2021
Very excited to have our collobaration work with Sukbok Chang selected as the Synfact of the Month! Thank you @MarkLautens and @thiemechemistry
22 Jul 2021
❇️ In this Synfact of the Month @MarkLautens and Joachim Loup highlighted the ✨Synthesis of Hydrazides by N–N Coupling ✨ reported by @GongChenLab from @NanKaiUniv 👏 👉 fal.cn/3gVJB
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Gong Chen retweeted
25 Mar 2021
Check out @gongchenlab, Xiaojie Lu et al.'s latest article 😍⬇️
Streamlined construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation in solution and on DNA 🔗 ow.ly/K5vm50E6bVZ
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23 Mar 2021
Simple FeCl2 catalyst enables a very efficient method to make N-N bond. A great collaboration with Prof Sukbuk Chang #KAIST. Please check out our latest research on #nitrene chemistry, published in @NatureChemistry
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19 Mar 2021
Our first study on DNA-encoded library synthesis. The Pd-catalyzed S-arylation chemistry is very effective and robust under biocompatible conditions. Many thanks to Xiaojie Lu at SIMM for a great collaboration!
- now published in Chemical Science pubs.rsc.org/en/content/arti…
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16 Feb 2021
Very proud of this chemistry 🤪
15 Feb 2021
Cooperative Stapling of Native Peptides at Lysine and Tyrosine or Arginine with Formaldehyde (Chen) onlinelibrary.wiley.com/doi/…
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Gong Chen retweeted
7 Jan 2021
NEW in @ChemicalScience 📢 A Rapid and Sensitive Method for Chiroptical Sensing of α-Amino Acids via Click-like Labeling with o-Phthalaldehyde and p-Toluenethiol by @GongChenLab et al.
Read it here for free! 🔗 ow.ly/vLUS50D28IW
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