@HaemEdDocRob profile picture
Dr Robert Ayto @HaemEdDocRob

Haematology Education. Portsmouth Hospitals University Trust. Haematology Consultant. Work with fantastic colleagues. Dog lover. Football fan. All views my own.

Joined June 2022
  • Tweets 217
  • Following 440
  • Followers 799
57 Photos and videos
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Dr Robert Ayto@HaemEdDocRob
14 Jun 2022
I'm a Haematology Consultant in Portsmouth, UK, passionate about educating the next generation of haematologists and biomedical scientists. This account will keep you up-to-date and support FRCPath exam prep. Outside of work, it's all about the dogs!
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60-year-old presents with cytopenias. Please see the linked questions. #hematology #MedTwitter #hematology Reference:- tinyurl.com/5n96xf5v
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What is the diagnosis and likely genetic abnormality?
9% AML t(9;22)
19% AML t(15;17)
57% AML inversion 16
15% AML t(6;9)
105 votes • Final results
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What would be the best treatment option for this fit female?
18% DA
44% DA Mylotarg
13% Ventoclax Azacytidine
25% DA Mylotarg Allograft CR1
61 votes • Final results
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What haematological condition is associated with these X-ray and clinical findings? #hemepath #hematology #MedEd See linked question
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What is the most likely haematological abnormality?
27% T-ALL
38% PRCA
29% Hodgkin
7% Gray Zone Lymphoma
105 votes • Final results
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Which cytogenetic is mostly likely to be found in this condition? See linked poll #hematology #hemepath #frcpath
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What is the most likely cytogenetic abnormality
26% t(8;14)
32% t(11;14)
24% t(2;5)
18% t(14;18)
123 votes • Final results
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Which of these features is not a flow cytometry characteristic of CLL? MFI - median fluorescent intensity
8% CD200 pos
56% ⬆️B cell antigen MFI
12% CD23/CD5 dual expression
23% 4/5 Matutes score
64 votes • Final results
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Dr Robert Ayto retweeted
European Hematology Association
@EHA_Hematology
12 Aug 2022
Welcome back to the #EHA #ThinkingThursday on diagnostic criteria of #mastocytosis: were your answers correct?
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Patient presents with pancytopenia - trephine below. IHC showed cells were CD20 pos, Bcl2 neg, CD10 pos and Bcl6 pos. What is the diagnosis? Reference:- bit.ly/3z3ODOf #hematology #hemepath #pathology
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Excellent - active monitoring
Dr Robert Ayto@HaemEdDocRob
23 Jul 2022
Replying to @HaemEdDocRob
The patient underwent bi lateral breast implant removal and total en bloc capsulectomy. There was no capsular penetration and tumour cells penetrated the luminal side of the capsule only. CT PET showed no sites of FDG avid disease. What treatment would you recommend?
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Correct FLT3-ITD!
Dr Robert Ayto@HaemEdDocRob
20 Jul 2022
Which subset of patients would benefit least from Venetoxlax and Azacytidine? #hematology #hemeonc
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Correct answer ALK-be BIA Anaplastic - still time to vote on treatment
Dr Robert Ayto@HaemEdDocRob
23 Jul 2022
Replying to @HaemEdDocRob
What is the most likely diagnosis? AL = anaplastic lymphoma HD = Hodgkin disease BIA = Breast Implant Associated
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Patient presents with splenomegaly, cytopenias and fatigue. A bone marrow was performed. HE below. What is the likely diagnosis? #path #oncology #hemepath bit.ly/3yYIxP0
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Patient presents with night sweats, weight loss, itchiness and anaemia? Abnormal cells stain for CD15, CD30, EBER and MUM1 but CD45-ve. What is the cell and diagnosis? #hemepath #MedTwitter #haematology #hematology bit.ly/3zowRq9
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A 56 year old female presents with a left breast Seroma - she has previously undergone bi lateral breast implants. Cytology and immunocytochemistry of a suspicious cell infiltrate is seen below. See thread. #lymphoma #hemepath #hematology reference:- bit.ly/3cE43kI
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What is the most likely diagnosis? AL = anaplastic lymphoma HD = Hodgkin disease BIA = Breast Implant Associated
40% BIA ALK-ve AL
5% HD
0% CD30 ve PTCL, NOS
55% BIA ALK AL
20 votes • Final results
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The patient underwent bi lateral breast implant removal and total en bloc capsulectomy. There was no capsular penetration and tumour cells penetrated the luminal side of the capsule only. CT PET showed no sites of FDG avid disease. What treatment would you recommend?
5% Radiotherapy
10% CHEOP plus radiotherapy
76% Active monitoring
10% Brentuximab monotherapy
21 votes • Final results
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Which subset of patients would benefit least from Venetoxlax and Azacytidine? #hematology #hemeonc
26% NPM1 ve, normal cyto
38% FLT3 ITD ve, normal cyto
13% FLT3 TKD, normal cyto
23% IDH2 mutated
61 votes • Final results
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Dr Robert Ayto retweeted
Multiple Myeloma Hub
@MM_Hub
4 Jul 2022
NEWS 🚨 @US_FDA grants talquetamab breakthrough therapy designation. This decision was based on new data from the MonumenTAL-1 trial, which were presented at #EHA22. Read more here: 👉 loom.ly/7uFjEYo 👈 #myeloma #mmsm #mednews
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