Scientist @Syenex. Chemical Engineering PhD @TheLeonardLab @NorthwesternU. @Penn alum. Mammalian synthetic biologist engineering cells to make smarter drugs.
Joined February 2019
- Tweets 48
- Following 350
- Followers 210
- Likes 479
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Pinned Tweet
22 Aug 2025
Delighted to share the final version of this paper out now! I led this project with @amparo_cosio during my PhD in @TheLeonardLab to investigate how we could program smart cell therapies to sense and respond to markers of disease—taking inspiration from natural human receptors!
22 Aug 2025
How can we combine the exquisite function of natural receptors with the programmability of synthetic biology? Check out this exciting new story led by @HaileyEdelstein and @amparo_cosio out today in @nchembio
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Hailey Edelstein retweeted
28 Aug 2025
A new study by @LurieCancer member Joshua Leonard, PhD, could ultimately enable the development of safer and more effective treatments for #cancer using ‘smart’ cell therapies." spr.ly/6019f2Yfv @TheLeonardLab @NUSynBio @NorthwesternEng @HaileyEdelstein @amparo_cosio
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22 Aug 2025
Thank you to @NorthwesternEng for covering our paper! mccormick.northwestern.edu/n…
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Hailey Edelstein retweeted
5 Jul 2024
Excited to share our work @NatureComms on biomembranes, lipid rafts, drug delivery, and extracellular vesicles (EVs). We used lipid-protein interactions to control protein trafficking and improve functional delivery of transcription factors > 50X! tinyurl.com/ycprfywe (1/8)
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25 Mar 2024
I’m thrilled to finally share this work from the Leonard lab and grateful for a fantastic team, especially my coauthor @amparo_cosio!
25 Mar 2024
New preprint! Here we introduce NatE MESA – high performing synthetic cytokine receptors that are robust and modular (led by @HaileyEdelstein & @amparo_cosio): biorxiv.org/content/10.1101/…
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Hailey Edelstein retweeted
17 Dec 2023
Red blood cells have some wildly cool capabilities – what if we could engineer them to work as living diagnostics? Check out this exciting first step (led by @TaylorDolberg & @taylor_gunnels): biorxiv.org/content/10.1101/…
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Hailey Edelstein retweeted
27 Nov 2023
VERY excited to welcome this paper out in @natBME where we introduce the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles
nature.com/articles/s41551-0…
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Hailey Edelstein retweeted
2 May 2023
What a fun collaboration with @NehaPKamat & @UWproteindesign led by @jperuzz & @taylor_gunnels - dig in for some fascinating EV science and useful EV bioengineering tools that we are thrilled to share
1 May 2023
Have you ever wondered how to improve loading of protein cargo into extracellular vesicles? Excited to share our latest work exploring how lipid-protein interactions may be leveraged to direct proteins into extracellular vesicles! tinyurl.com/45sdm55m 🧵 1/6
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Hailey Edelstein retweeted
1 May 2023
Have you ever wondered how to improve loading of protein cargo into extracellular vesicles? Excited to share our latest work exploring how lipid-protein interactions may be leveraged to direct proteins into extracellular vesicles! tinyurl.com/45sdm55m 🧵 1/6
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Hailey Edelstein retweeted
21 Dec 2022
Hello darkness my old friend...Have you ever had your transgene or synthetic gene circuit silence? Check out this awesome collaborative review by many leaders in mammalian synbio. sciencedirect.com/science/ar…
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We’re thrilled to be selected by @abbvie for their 2022 AIM award! Great work team! @TheLeonardLab @jdrosanelli @DevinStranford @HaileyEdelstein
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Hailey Edelstein retweeted
16 May 2022
I’m thrilled to introduce a story that has been many years in the making – the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles
biorxiv.org/content/10.1101/…
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Hailey Edelstein retweeted
20 Apr 2022
Check out a fun new perspective on super-cool recent work by @ElowitzLab, Richard Murray and team in @GENBiotechJrnl (with @HaileyEdelstein and @_gauribora ) liebertpub.com/doi/10.1089/g…
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Hailey Edelstein retweeted
12 Apr 2022
Happy to share that our study on engineering nanoscale decoys to fight COVID-19 is now published! A big thank you to the team for your hard work, advice, & mentorship! (@TheLeonardLab @NehaPKamat @DevinStranford @roxi_mitrut )
12 Apr 2022
Our latest work: teaming up with @NehaPKamat to show how engineered biologic vesicles work as nanoscale decoys that prevent cellular infection by SARS-CoV-2 and retain efficacy against key mutant variants:
onlinelibrary.wiley.com/doi/…
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Hailey Edelstein retweeted
20 Jan 2022
Very psyched to see this paper out in the world - it is the review we wish existed! Hope this is as much fun to read as it was to write with @LeonardoMorsut, @HaileyEdelstein, and @JanvieManhas with great input from Terry Sheppard from @nchembio
20 Jan 2022
Synthetic receptors have come a long way! We’re very excited to share this comprehensive review of the origins, development, and state-of-the art of this field, co-written with @TheLeonardLab in @nchembio
nature.com/articles/s41589-0…
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20 Jan 2022
I’m so proud to see this review finally out! The synthetic receptor space is evolving quickly and capturing that development here was all around fun! Thanks to my co-authors for all of the brainstorms and teamwork. It’s been a blast! @JanvieManhas @TheLeonardLab @LeonardoMorsut
20 Jan 2022
Synthetic receptors have come a long way! We’re very excited to share this comprehensive review of the origins, development, and state-of-the art of this field, co-written with @TheLeonardLab in @nchembio
nature.com/articles/s41589-0…
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Hailey Edelstein retweeted
3 Sep 2021
Happy to share our new review on the power of using process control concepts to understand and build genetic programs in mammalian cells by @dray_kate @HaileyEdelstein @kdreyer96 @NorthwesternEng @NUSynBio sciencedirect.com/science/ar…
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Hailey Edelstein retweeted
25 Jun 2021
Thanks @NIBIBgov for highlighting this cool project led by @JoeJMuldoon with @BagheriLab @NUSynBio nibib.nih.gov/news-events/ne…
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Hailey Edelstein retweeted
19 Feb 2021
Our new study on predictive design of mammalian genetic programs is out in @ScienceAdvances! We paired engineered genetic parts that have special capabilities with computational models to design circuits that perform sophisticated, useful functions advances.sciencemag.org/cont…
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Hailey Edelstein retweeted
1 Feb 2021
Check out SPORT - a computational protein design strategy for making split proteins work for you! @NUSynBio @NorthwesternEng @VatsanRaman @UWMadison @NatureChemBio
nature.com/articles/s41589-0…
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