Run by members of the Bode Lab. Doing all things related to natural products.
Joined March 2019
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- Followers 556
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2 Photos and videos
6 Sep 2024
Happy to announce the first steps into NRPS/PKS engineering thanks to the work from Leonard and collaborations with the labs from Markus Kaiser and Michael Groll:
Bioengineering of syrbactin megasynthetases for immunoproteasome inhib... sciencedirect.com/science/ar…
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26 Jul 2024
Leonard has applied the XUT NRPS engineering technology to solve the biosynthesis of the potent antibiotic odilorhabdin in collaboration with the Rolf Müller lab at @Helmholtz_HIPS. See his paper in @angew_chem: doi.org/10.1002/anie.2024063…
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2 Apr 2024
CRISPR now also available for Xenorhabdus and Photorhabdus for easy access to natural products and manipulation of their biosynthesis: Please see the paper from Alexander in Microbial Cell factories: rdcu.be/dDibN
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21 Mar 2024
And here is another cool story about trans-AT PKS engineering in the same issue science.org/doi/10.1126/scie… from the @piel_lab. Congratulations!!
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21 Mar 2024
Finally! After a long journey our latest NRPS engineering story is out at science.org/doi/10.1126/scie… thanks to the hard work of several members from the @HelgeBode_lab
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29 Mar 2023
With our newest preprint on engineering NRPS we succeeded in optimizing our first-of-its-kind biocombinatorial technology. Read more here:
Guidelines for Optimizing Type S Non-Ribosomal Peptide Synthetases biorxiv.org/content/10.1101/…
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5 Dec 2022
The latest update for NRPS engineering, based on a evolutionary breakpoint within thiolation domains is out: doi.org/10.1101/2022.12.02.5…
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Bode Lab retweeted
2 Nov 2020
Next round in "the many things that regulatory RNAs can do" - this time: controlling natural-product synthesis. Fantastic collaboration with the Bode lab (@HelgeBode_Lab) published today in @NatureMicrobiol nature.com/articles/s41564-0…
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10 Apr 2020
An awesome addition to polyketide biosynthesis. TE disguises itself as KS
catalyzing branched polyketide formation. Read about Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A pubs.acs.org/doi/10.1021/jac…
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14 Jan 2020
Luckily, despite severe jet lag, Helge’s given a clear, nice talk @SIMB_Microbio #NaturalProducts on NRPS engineering with a more efficient approach. Showing the advantages of artificial docking domains in splitting and reconstructing the megasynthetases
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7 Nov 2019
Finally... more than a module! Great NRPS work from the Schmeing lab: Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility science.sciencemag.org/conte…
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21 Sep 2019
Who makes antibiotics and how do NRPS work? See the Grininger/Bode group performance for kids here: rz.uni-frankfurt.de/68128012…
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18 Sep 2019
🤔 could have submitted more
12 Sep 2019
JOC invites you to take a look at this Note from first-time corresponding author Helge Bode & coworkers: (±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 dx.doi.org/10.1021/acs.joc.9…
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We have new, hypermodified peptides for you! Check out our aeronamide (from Microvirgula) & polygeonamide (from deep-rock metagenome🤘🎸) story at @NatureChemistry nature.com/articles/s41557-0… #RiPPs
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15 Aug 2019
Natural products go RNA: The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation cell.com/cell-chemical-biolo…
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Read Jörn‘s @nature #behindthepaper on how we developed the TransATor, a web tool for de novo structure predictions of trans-AT polyketides & why you need it go.nature.com/2jL18eL
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The long-awaited TransAtor paper is out in @nchembio! TransAtor is a web application enabling de novo structural predictions of trans-AT PKS-derived polyketides. nature.com/articles/s41589-0…
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11 Jul 2019
First time to achieve peptide ligation in water, offering a chemical perspective of chicken-and-egg problem for the origin of life nature.com/articles/s41586-0…
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2 Jul 2019
Nice work by the Stanley-Wall lab: Pulcherrimin formation controls growth arrest of the Bacillus subtilis biofilm pnas.org/content/116/27/1355…
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Tom's amazing @NatRevChem review is finally out!! Learn more about hidden #enzymology, unprecedented chemistry & new approaches for exploring microbial dark matter at #naturalproducts nature.com/articles/s41570-0…
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