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Hiltunen Lab @HiltunenLab

Prof. Mikko Hiltunen's research group investigating #Alzheimer's Disease at @UniEastFinland; Director of UEF Neuroscience Research Community

Joined September 2017
  • Tweets 466
  • Following 437
  • Followers 682
55 Photos and videos
Congratulations to Heli Jeskanen, who just won the best poster award related to PMG-AD project in the JPND meeting at Brussels! @UEF_Biomed @UEFNeuroInno @UEFneuroscience
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Hiltunen Lab retweeted
A.I. Virtanen Institute@AIV_Institute
12 Sep 2024
Professori Annakaisa Haapasalo puhuu professuuriesitelmässään aiheesta "Otsalohkodementian translationaalinen tutkimus – molekyylimekanismeista tautibiomarkkereihin ja uusiin hoitoihin". #professuuriesitelmät #MeOlemmeUEF
University of Eastern Finland@UniEastFinland
10 Sep 2024
#UEF’in uudet professorit esittäytyvät perinteisissä professuuriesitelmissä Joensuun kampuksella 25.9. ja Kuopion kampuksella 27.9.2024. Tutustu professoreihin ja esitelmien aiheisiin verkossa: uef.fi/professuuriesitelmat. #professuuriesitelmät #MeOlemmeUEF uef.fi/fi/artikkeli/ita-suom…
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Please check our latest findings related to effects of PLCG2 variant on AD pathology @UEFneuroscience @SuomenAkatemia Protective variant in PLCgamma2 mitigates Alzheimer's disease associated pathology via enhancing beneficial microglia functions biorxiv.org/content/10.1101/…

Protective variant in PLCγ2 mitigates Alzheimer’s disease-associated pathologies via enhancing...

Background PLCγ2-P522R (phospholipase C gamma 2, proline 522 to arginine) is a protective variant that reduces the risk for late onset Alzheimer’s disease. Recently, it was shown to decrease β-amyl...

biorxiv.org
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Excellent collaboration with Maria Jose Diogenes group! A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease: Molecular Therapy cell.com/molecular-therapy-f…

A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in...

Diogenes, Rodrigues, and colleagues found that Aβ triggered the cleavage of BDNF's receptor from the early stages of AD and developed a TAT-fused peptide spanning the receptor's cleavage site. The...

cell.com
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uef.fi/fi/artikkeli/ita-suom…

Itä-Suomen Genomikeskuksen palvelut uudelle tasolle

Itä-Suomen Genomikeskuksen palvelut laajenivat syövän geenidiagnostiikkaan. FIRI-rahoitus toi uutta vauhtia palvelukokonaisuuksien kehittämiseen.

uef.fi
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Outstanding funding decision for UEF Neuroscience Research Community!@UEFneuroscience @kuo_brain_mind uef.fi/en/article/eu-funding…

EU funding for an interdisciplinary postdoctoral programme in brain health

The programme integrates neuroscience, data science, innovation management, and social and legal studies across three UEF faculties.

uef.fi
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University of Eastern Finland@UniEastFinland
15 Aug 2024
Pioneering study identifies six genetic regions associated with normal pressure hydrocephalus. Published in Neurology, the study is the first large-scale genome-wide association study related to NPH in the world. @GreenJournal @UEFneuroscience @KuopioNPH uef.fi/en/article/pioneering…

Pioneering study identifies six genetic regions associated with normal pressure hydrocephalus

The study is the first large-scale genome-wide association study related to NPH in the world.

uef.fi
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University of Eastern Finland@UniEastFinland
15 Aug 2024
Uraauurtava tutkimus tunnisti kuusi normaalipaineiseen hydrokefaliaan liittyvää geenialuetta. Kyseessä ensimmäinen laajamittainen koko genomin kattava tutkimus NPH-taudista maailmassa. @UEFneuroscience @Pshyvinvointi @HiltunenLab @KuopioNPH @ClinmedUef uef.fi/fi/artikkeli/uraauurt…

Uraauurtava tutkimus tunnisti kuusi normaalipaineiseen hydrokefaliaan liittyvää geenialuetta

Kyseessä oli ensimmäinen laajamittainen koko genomin kattava tutkimus NPH-taudista maailmassa.

uef.fi
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Six novel gene loci identified in normal pressure hydrocephalus! @KuopioNPH @SuomenAkatemia @FinnGen_FI @UEFneuroscience Risk Variants Associated With Normal Pressure Hydrocephalus | Neurology neurology.org/doi/10.1212/WN…

Risk Variants Associated With Normal Pressure Hydrocephalus | Neurology

Background and ObjectivesLarge-scale genome-wide studies of chronic hydrocephalus have been lacking. We conducted a genome-wide association study (GWAS) in normal pressure hydrocephalus (NPH).Metho...

neurology.org
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Comprehensive discussion in Nadine Huber’s PhD dissertation - Nadine is doing great!😊 @HaapasaloLab @HiltunenLab @UEF_Biomed @UEFneuroscience
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Cross-sectional study of plasma phosphorylated Tau 217 in persons without dementia medrxiv.org/content/10.1101/…

Cross-sectional study of plasma phosphorylated Tau 217 in persons without dementia

Importance Blood levels of phosphorylated tau 217 (p-tau217) as measured by commercially available immunoassays are an emerging tool to assess Alzheimer’s disease (AD) pathology. Little is known...

medrxiv.org
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Hiltunen Lab retweeted
Pattern Cog@PatternCog
27 May 2024
📢Publication of the first study investigating how genetic factors influence changes in neuroimaging markers during a 2-year multidomain lifestyle intervention Congrats to the authors👏 @drsaadmaan @HiltunenLab @TiiaNgandu @HilkkaSoininen @MiiaKivipelto alz-journals.onlinelibrary.w…

Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial

INTRODUCTION We assessed a genetic risk score for Alzheimer's disease (AD-GRS) and apolipoprotein E (APOE4) in an exploratory neuroimaging substudy of the FINGER trial. METHODS 1260 at-risk older ...

alz-journals.onlinelibrary.wiley.com
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Hiltunen Lab retweeted
NeurocenterFI@NeurocenterFI
23 May 2024
⁦Apoe4-tuplageeni ei aina aiheuta muistisairautta, vaikka lisääkin riskiä. Elintavat vaikuttavat, sanoo Mikko Hiltunen ⁦@kuo_brain_mind⁩ @UEFneuroscience⁩ ⁦@UniEastFinland⁩ ⁦@HiltunenLab⁩ ⁦⁦⁦⁦⁦@Kuopionkaupunki⁩ hs.fi/tiede/art-200001042546…

Muistisairaudet | Tutkimus: Tietty perimä johtaa Alzheimerin tautiin – Joka 50:s suomalainen kantaa...

Apoe4/4-geenimuoto ei automaattisesti aiheuta muistisairautta, sanoo professori Mikko Hiltunen. Kyse on edelleen riskistä.

hs.fi
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Hiltunen Lab retweeted
FinnGen@FinnGen_FI
17 May 2024
A new preprint from Mikko Hiltunen's group utilises FinnGen to show that the Finnish TYROBP deletion associates with an increased risk and earlier onset of dementia and Alzheimer’s disease in the monoallelic carriers.
Hiltunen Lab@HiltunenLab
11 May 2024
Happy to share our recent preprint Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease medrxiv.org/content/10.1101/… - Thanks to Henna and all other co-authors! @SuomenAkatemia @SigridJuselius @JPNDeurope @UEFneuroscience @UEF_Biomed
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Happy to share our recent preprint Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease medrxiv.org/content/10.1101/… - Thanks to Henna and all other co-authors! @SuomenAkatemia @SigridJuselius @JPNDeurope @UEFneuroscience @UEF_Biomed

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease

Biallelic loss-of-function variants in TYROBP and TREM2 cause autosomal recessive presenile dementia with bone cysts known as Nasu-Hakola disease (NHD, alternatively polycystic lipomembranous...

medrxiv.org
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Hiltunen Lab retweeted
Alzforum@alzforum
9 May 2024
The #alzheimersdisease risk gene PLCγ2 acts in neurons as well as microglia, maintaining synapse number and excitability. @PasteurLille ow.ly/NnqW50RASxy
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Great collaboration with Lambert lab - Neuronal downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease hallmarks biorxiv.org/content/10.1101/…

Neuronal downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease hallmarks

We developed a high content screening to investigate how Alzheimer disease (AD) genetic risk factors may impair synaptic mechanisms in rat primary neuronal cultures. Out of the gene targets identif...

biorxiv.org
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Hiltunen Lab retweeted
University of Eastern Finland@UniEastFinland
18 Apr 2024
Kansainvälinen @alzassociation myönsi Neurotieteiden tutkimusyhteisön tutkijoille merkittävän rahoituksen hankkeeseen, jossa tutkitaan Alzheimer-riskiin liittyvien TMEM106B-geenimuutosten vaikutusmekanismeja. @UEFneuroscience @HiltunenLab @LabMalm uef.fi/fi/artikkeli/merkitta…

Merkittävä kansainvälinen rahoitus Alzheimer -riskigeenimuutosten vaikutusmekanismien selvittämiseen

Alzheimer’s Association myönsi Neurotieteiden tutkimusyhteisön tutkijoille strategisen rahoituksen hankkeeseen, jossa tutkitaan Alzheimerin taudin riskiin liittyvien TMEM106B-geenimuutosten vaikutu...

uef.fi
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UEF Neuroscience@UEFneuroscience
13 Mar 2024
Replying to @KuopioEpilepsy
@KuopioEpilepsy Workshop panel discussion on Biomarkers for Epilepsies and Neurodegenerative Diseases with Valtteri Julkunen (@FinnGen_FI), @rkalviainen, @HiltunenLab and Susanne Bäck (@CRiverLabs)
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Hiltunen Lab retweeted
UEF Neuroscience@UEFneuroscience
29 Feb 2024
"Dementia is not one specific disease, instead it is an overarching term describing a group of diseases characterized by progressive cognitive decline, associated with degeneration of brain matter." Find out more by reading the post written by our PhD researcher Elena Ppali 🧠
UEF Neuro-Innovation@UEFNeuroInno
29 Feb 2024
Let’s talk dementia! 🔵What is ‘Dementia’? 🔵What are the symptoms? 🔵How many types of Dementia exist? Read Elena Ppali's post to find out! sites.uef.fi/neuro-innovatio… #dementia #dementiaawareness #brainhealth #msca #horizon2020 @UEFneuroscience @HaapasaloLab
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