It was awesome to have the legendary Immortal Time Lord @DrToddLee as Visiting Professor at LA General today. Everyone loved it. I highly recommend to others out there, invite him over! Great case conference discussion, awesome on rounds, great lecture! Thank you! @LAGeneral_ID
It was awesome to have the legendary Immortal Time Lord @DrToddLee as Visiting Professor at LA General today. Everyone loved it. I highly recommend to others out there, invite him over! Great case conference discussion, awesome on rounds, great lecture! Thank you! @LAGeneral_ID
This week, we celebrate our incredible Infection Prevention and Control (IPC) team! They work tirelessly to keep everyone safe, leading with science, vigilance, and compassion. Special thanks to Dr. Noah Wald-Dickler for his outstanding leadership.
Vanco pulse taper should supplant Vanco 10 days for CDI at all stages
Now --- fidaxo vs Vanco pulse taper needs larger numbers and longer follow up
See how fidaxo catches up to Vanco 10 days at day 56
@DrEmilyMcD@ABsteward
👨🏫Great presentation by Dr. Johnson on RCT of Vancomycin Taper/Pulse and Fidaxomicin compared to Vancomycin for Treatment of First or Second rCDI
🔥 The VA CSP596 trial
📋3 arms
1) Vancomycin taper/pulsed (VAN-TP)
2) Fidaxomicin x10d (FDX)
3) Vancomycin x10d (VAN)
#IDWeek2025
Some teams do trust falls. We do Ebola PPE donning & doffing: equal parts choreography, duct tape, sweating and totally unnecessary PAPRs. But lots of fun & learning. #InfectionPrevention@LAGeneralMed@LAGeneral_ID
I've been hearing a lot about this common concern: "Are kids getting too many vaccines?"
It's a fair question. I'm a parent too. And as an infectious diseases physician who directs an antibiotic stewardship program, a big part of my job is stopping unnecessary medications. I'm a minimalist by nature - both personally and professionally.
But here's what most people don't realize:
A shocking fact in vaccine science: Kids today are exposed to FEWER antigens from vaccines than children in 1900 - when there was literally ONE vaccine (smallpox).
In 1986, kids received about 10 shots protecting against 7 diseases. Those vaccines exposed them to over 3,000 antigens - the pieces of viruses or bacteria (like proteins or sugars) that teach the immune system to recognize and respond to real infections.
Today's schedule includes more injections - about 50 by age 18 - but the total number of antigens is just ~150. That's a 95% reduction in antigen exposure, thanks to modern acellular and conjugate vaccine designs.
The data over 18 years (Offit et al., Pediatrics 2002):
🔹1900: 1 vaccine (smallpox) = ~200 antigens
🔹1986: ~10 vaccines = 3,000 antigens 3mg aluminum
🔹2025: ~50 vaccines = ~150 antigens 5-6mg aluminum
As for aluminum adjuvant - a compound added to help trigger a stronger immune response - children today receive about 5–6 mg total over the full vaccine schedule, up from ~3 mg in 1986. That's a modest increase over 18 years. For perspective, infants ingest ~7–10 mg of aluminum just in their first six months from breast milk or formula.
So yes, there are more shots. But the actual antigen exposure is dramatically lower than it was in 1986 - or even 1900. Modern vaccines stripped out thousands of extra proteins while adding protection against Hib meningitis, pneumococcal sepsis, chickenpox complications, liver cancer, HPV cancers, and more.
TL;DR: Modern vaccines do far more with less. That's progress. Let's not go backwards.
@BradSpellberg@mtosterholm@ReporterGoodman@HelenBranswell@thekibosch@ENirenberg@AliSMV7@atrupar@alejodiaz81@zacroBID@ThePharmFox@DhandAbhay
LA General achieved Leapfrog A! We appreciate the entire hospital’s efforts to get here and honored to be part of it in infection control & prevention!
We’re hiring in Infectious Diseases at @LAGeneralMed!
Join @BradSpellberg, @rachelpbaden, @docDavar, @SarahRawi1, @clarkithrimycin and others as we pave the way in clinical care and innovation in ID, Antimicrobial Stewardship, HIV, HepC, TB and more!
Gowns should no longer be part of PPE for SARS-CoV-2 infection.
Gowns role in Infection Prevention is as part of standard precautions: use if there is risk of contact with blood/body fluids.
@G_ROD_11, @dan_diekema, and I wrote about this some time ago:
cambridge.org/core/journals/…
Dr. Holtom’s been a quintessential mentor, teacher, professional father figure and (I’m grateful now to say) friend for 12 years. He fostered my love for & growth in both clinical Infectious Disease & Hospital Epidemiology. I’ll miss him dearly & am profoundly grateful.
Ben Franklin wrote “Tell me and I forget. Teach me and I may remember. Involve me and I learn.” From Paul I have learned and will remember so much. @PaulHoltom: all my sincerest thanks and truest wishes for your happiness and our continued friendship.