Doxurubicin increases breast cancer risk independent of age or RT!
1964 pts mFU 21.6 years.
Survivors treated with >200 mg/m2 Dox had a 1.5-fold increased BC risk, cf no Dox. BC risk increased 1.18-fold per additional 100 mg/m2 Dox (Ptrend = .004).
ascopubs.org/doi/10.1200/JCO…