We study host-bacteria interactions using Listeria and MS-based Proteomics with a focus on Ubiquitin-like modifications (e.g. ISG15) and MHC complex peptides.
Joined October 2021
- Tweets 56
- Following 109
- Followers 193
- Likes 139
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Impens Lab retweeted
16 Mar 2025
๐ Boosting bacterial immunopeptide discovery! Our bioinformatics workflow integrates 4 search engines with follow-up rescoring to enhance ID by 27%, maximizing the discovery of vaccine candidates. Applied to timsTOF/Thermo data๐ฆ ๐ @ImpensLab
๐Read: pubs.acs.org/doi/full/10.102โฆ
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Impens Lab retweeted
24 Nov 2024
Happy to share our immunopeptidomics pipeline using four search engine with follow-up rescoring to boost confident IDs. Also applied to timsTOF SCP data!
@ImpensLab @compomics
Preprint: biorxiv.org/content/10.1101/โฆ
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14 Aug 2024
Excited to share our latest MCP article uncovering > 6,000 MHC class I immunopeptides in Listeria-infected mice, including 12 Listeria peptides and a potent CD8 T cell epitope. Many thanks to all co-authors for the excellent work! Read more at doi.org/10.1016/j.mcpro.2024โฆ
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Here it is: our paper on the benefit of using in silico predicted libraries in DIA ๐๐๐๐๐
pubs.acs.org/doi/10.1021/acsโฆ
@KrisGevaert_VIB @RalfGabriels @RobbinBouwmees @SaraDuf79861163 @mtpmmaia @VIBProteomxCore @ImpensLab
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Proud to have it out there! The setup that boosts our throughput!๐ช๐ pubs.acs.org/doi/10.1021/acsโฆ
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Impens Lab retweeted
11 Dec 2023
Meet SlyB, a lipoprotein that forms stress-induced #lipidraft in the bacterial outer membrane.
Off the hands of the great @ArneJanssens95 and @nguyenson85, in collaboration with @JFClab @ImpensLab and Alex Pak lab.
@structbiolbxl @BECM_VIB
nature.com/articles/s41586-0โฆ
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Impens Lab retweeted
2 Oct 2023
๐Congratulations to @kkariko & @weissmanlab on becoming #NobelPrize laureates. A lifetime achievement celebrating their important research on #mRNA technology in vaccines.
๐คDid you know VIB, together with @VUBrussel, @ugent and participation of several international institutes helped establish the #BAXERNA consortium to further explore the potential of mRNA vaccines?
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5 Jun 2023
We are looking for a #postdoc position in #immunopeptidomics @ VIB & UGent with proteomics/peptidomics expertise to develop novel antibacterial #vaccines, see jobso.id/g492. A warm call to proteomics postdocs to apply!
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Impens Lab retweeted
28 Feb 2023
Research on #Moyamoya disease @ImpensLab: "Rare diseases result from dysregulated, often yet unknown molecular pathways. Investigating these conditions can lead to groundbreaking fundamental discoveries while opening treatment options for the patients."
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31 Jan 2023
We are very excited and extremely grateful to receive this #ERCCoG grant from @ERC_Research. It is a recognition for the whole team and we thank @VIB_CMB @ugent @ugent_fge @VIBLifeSciences @FWOVlaanderen and many others for their continuous support!
31 Jan 2023
๐ More wonderful @ERC_Research news! @ImpensLab has received an #ERC Consolidator grant for his research on #Moyamoya disease (#MMD). With this grant, the Impens Lab hopes to provide unprecedented insight into MMD-related immune responses! ๐ bit.ly/3RgnPD7
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31 Dec 2022
Another wonderful story from the Radoshevich lab. A must-read (and watch!) for all Listeria and comet tail aficionados.
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Impens Lab retweeted
17 Oct 2022
๐ Francis Impens and team (@ImpensLab @VIB_PRC @VIB_CMB) design an mRNA vaccine against Listeria and open the door for other antibacterial vaccines.
bit.ly/3g89LwR
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17 Oct 2022
Finally published!
Thank you all co-authors for their priceless contribution!
Here we designed mRNA vaccine formulations against Listeria using immunopeptidomics
Looking forward to continue our efforts to tackle other intracellular bacterial pathogens
tinyurl.com/vaccineListeria
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16 Sep 2022
Happy to share our new review on Moyamoya disease and RNF213, a disorder for which the etiology is still unknown.
Here, we examined the recent body of literature suggesting immune-related insults as a trigger for Moyamoya disease onset.
cell.com/trends/molecular-meโฆ
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Impens Lab retweeted
30 Aug 2022
First day of the 4-day BePA Proteomics Summer School @ VIB starting with interesting talks on Proteomics applications and the DOs and DONTs of sample preparation
๐๐ bit.ly/3CELRCf
#proteomics #tech #training #summerschool
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23 Aug 2022
Very happy to share our work on mRNA vaccine formulations against Listeria
MS and immunopeptidomics hold great promise to uncover antigens for next-generation vaccines, especially for intracellular bacteria. Incredibly grateful to all co-authors for their dedication and efforts!
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