Single-molecule biophysicist, CRC T2, MSFHR Scholar, building responsive DNA nanostructures to study biology. Views are my own. @fos_ubco @ubcokanagan 🇨🇦
Joined June 2010
- Tweets 372
- Following 509
- Followers 371
- Likes 676
43 Photos and videos
Isaac Li retweeted
26 Jun 2025
@IsaacLiLab and team show that adding excess decoy DNA protects DNA-based probes from DNase degradation, preserving probe integrity for over 48 hours and enabling robust, long-term mechanobiology studies in live-cell environments #openaccess 🔓 onlinelibrary.wiley.com/doi/…
2
2
150
25 Jun 2025
Latest from the lab:🧬Decoy DNA🧬can extend the lifetime of DNA-based tension probes >24h by outcompeting DNases and preserving signal integrity in live-cell tension imaging - simple, general strategy for robust mechanobiology in DNase-rich environments. doi.org/10.1002/anie.2025065…
4
14
807
Isaac Li retweeted
1 May 2025
Methods and Applications in Fluorescence MAF 2025 August 24-27 in Montreal Canada
Abstract deadline for talk consideration May 12
Abstract deadline for poster presentations June 2
Early Registration deadline June 25
Join us in Montreal for MAF 2025!
maf2025.org/en
2
4
301
18 Apr 2025
Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏
#DNAPAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs.2024082…
1
12
922
Isaac Li retweeted
2 Apr 2025
The 10th annual BSC meeting is coming up in Hamilton!
Don't miss the April 15 deadline for early registration, abstract submission, and travel awards.
Details & program: event.fourwaves.com/bsc2025/ #BSC2025
2
1
207
Isaac Li retweeted
2 Apr 2025
The 10th annual meeting of the Biophysical Society of Canada will be held May 20-23 at McMaster University in Hamilton, ON.
Check out the speaker lineup and programs here: event.fourwaves.com/bsc2025/
Early registration and abstract submission deadlines are April 15. #BSC2025
2
3
240
15 Mar 2025
David Bakker from my group is talking to middle school students about our research on DNA and optical tweezers!🧬Great job, David, for bringing the latest science to the grade 6-10 classrooms! career.sd83.bc.ca/2025/03/14…
#biophysics #outreach
2
125
12 Mar 2025
We just published a review on recent progress in integrin force loading rate measurement using various molecular tension probes. Learn more about how this has advanced the field and what potential improvement lies ahead here: doi.org/10.1017/qrd.2024.28
#mechanobiology
3
14
385
Isaac Li retweeted
10 Mar 2025
Celebrate #BiophysicsWeek w/ 3 trainee-organized virtual events to connect, learn, and have fun:
🧠Trivia Night – Mar 24, 6PM ET
🎤Career Research talk @IsaacLiLab – Mar 27, 1:30PM ET
🥖Biophysical Gastronomy – Mar 29, 2PM ET
📍Register here:
events.teams.microsoft.com/e…
2
5
229
31 Oct 2024
The tradition continues! UBCO Chemistry pumpkin carving contest organized by the CGSS! Check them out on FIP 3rd floor! 🎃🎃🎃👻👻👻 @fos_ubco @UBCOGradstudies @bccu_ubco @UBCO_CCU
3
7
374
Isaac Li retweeted
29 Oct 2024
Free scientific illustrations for biologists! 😍
@NIH has released a library of 500 free scientific illustrations to create figures, presentations, and illustrations!
all freely available in the public domain.
Retweet and spread the message!
bioart.niaid.nih.gov/
45
2,361
5,588
582,376
25 Oct 2024
Thank you @BiophysCanada, for this recognition! I'm truly honoured to be receiving this award. Huge shoutout to my fantastic team: this wouldn’t have been possible without them. We're excited to see what's coming in the next few years!
25 Oct 2024
The Biophysical Society of Canada is excited to announce Dr. Isaac Li @IsaacLiLab as the 2025 Early Career Investigator Awardee! Dr. Li's work on force-responsive DNA nanostructures and force imaging methods opens new avenues in understanding cellular functions. Congratulations🎉
6
1
17
722
12 Oct 2024
I am excited to share our latest work on creating the first tunable Catch-Bond with #DNA! Our Fish-Hook architecture allowed precise control of adhesion nanomechanics, creating new possibilities for bioengineering and material science! 🧬🐟🪝🌟nature.com/articles/s41467-0… #biophysics
5
14
30
2,349
12 Oct 2024
This work was spearheaded by two talented PhD students, Micah and David. Their outstanding effort in optimizing the optical trap setup and experiments and developing the theoretical, analytical, and simulation platforms turned a concept into reality. #proudPI
188
Isaac Li retweeted
4 Oct 2024
Applications received by November 15, 2024 will receive full consideration. For a full description and application instructions, see
sfu.ca/physics/about-us/empl…
(For dual-career searches, tenure-track positions in other areas of Physics will be posted to this link soon.)
5
4
703
31 Jul 2024
Yes!!!! So proud of the 🇨🇦 Women's Soccer Team!
31 Jul 2024
Through to the quarter-finals! ⚽
The defending Olympic champions have advanced after a 1-0 win over Colombia 🇨🇦
#TeamCanada | #Paris2024 | @RC_Sports #rcsports #soccer
3
241
2 Jul 2024
Our work on Altering Cell Junctional Tension in Spheroids through E-Cadherin Engagement Modulation just got published! We showed that E-cad tension can be monitored and modulated using membrane-anchored DNA probes and strand-displacement reactions!
pubs.acs.org/doi/10.1021/acs…
3
7
39
2,259
30 May 2024
Congratulations 🎉 to Seongho and Adam for getting poster awards at @BiophysCanada annual meeting! You guys are on fire!!
6
263
30 May 2024
Congratulations 🎉 to Micah for receiving a travel award at @BiophysCanada annual meeting!
3
191