Journalist @ApexOnco. The Wolverine Of Biotech / Mr ASH. Never paid for a blue tick. Interested in: oncology. Not interested in: what stock you bought today.
What a week so far:
$RHHBY$NRIX deal
$JNJ buys Firefly
$GSK buys $NUVL$PBLS $770m IPO $100m placement
$TRLN going public by reverse merger ($900m cash)
$TNGX $600m secondary
$IDYA $300m secondary (on the back of Tango)
$SMMT $575m secondary (on disappointing #ASCO26 data)
Some context for that 92% ORR / 90% 6mth landmark PFS in pancreatic cancer for the $TNGX vopimetostat daraxonrasib combo:
vopimetostat monorx 25% ORR, ~90% 6mth PFS
$RVMD daraxonrasib monorx 32%, 6mth PFS 56%
Why is $NRIX still on the hook for 40% of bexobrutideg's development costs? Does it get to keep zelebrudomide for itself? Hopefully more clarity coming on today's investor call $RHHBY
Interesting question, given recent discussions: why didn't $RHHBY just go to China and pay a tenth of the price? I see at least 2 other clinical-stage BTK degraders in development at Chinese bios ( several preclinical). $NRIX
Actually, no: Avencell appears to be Unum 2.0 (I'm sure @PDRennert remembers how that worked out). Non-targeting Car "soluble" linking thingy with ScFv
And some interesting thoughts from Matthew Goetz on practical issues over $AZN Serena-6 study. Relevant as FDA continues to assess camizestrant and the negative 6-3 adcom vote. #ASCO26