Joined December 2016
3 Photos and videos
Jan Michler retweeted
Super excited about this new preprint of the lab 🚀🚀. Congrats to @cocoborrelli and all coauthors. Our research delves into the world of tumor-hepatocyte interactions, spotlighting #PlexinB2 as a key player in regulating liver metastasis.
Soooo happy to share the results of my PhD project in the @moorlab! The seed and soil hypothesis postulates that metastases will only grow in favorable environments. Here we forget about the seed and focus on the soil. Which factors in the liver promote or suppress seeding? 🧵👇
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Jan Michler retweeted
2 May 2023
New research from our collaboration with the Boyman lab at @UZH_ch now published in @NatImmunol: rdcu.be/daYti! Check it out to learn about memory B cell plasticity, longitudinal tracking of B cell clones and much more performed by @ZurbuchenY and @JanMichler! Digest:🧵

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Jan Michler retweeted
29 Apr 2023
Our paper on the memory B cell response to SARS-CoV-2 infection is out! It's been a great collaboration with @JanMichler and the @moorlab team with many exciting discussions, some depressing evenings when the machines failed us, but more than worth it!
Boyman and colleagues find that human SARS-CoV-2-specific memory B cells can follow phenotypically and functionally different trajectories after antigen reexposure. Read it here: rdcu.be/daYti nature.com/articles/s41590-0…
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Jan Michler retweeted
Congratulations, Andreas @AndreasMoor, on being elected member of the Young Investigator Programme of the European Molecular Biology Organisation @EMBO_YIP! > bit.ly/3goeXNN @ETH_en

22 Nov 2022
🎉 Welcome our 24 new Young Investigators joining the @EMBO_YIP network! The new YIPs will receive financial and practical support for a period of four years, starting in January 2023 – congratulations! ➡️ Read more in the press release here: embo.org/press-releases/embo…
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Jan Michler retweeted
2 Nov 2022
We are excited to share our new preprint about our development of a new #spatialTranscriptomics method (sphere-sequencing) to unveil local tissue microenvironments at single cell resolution! biorxiv.org/cgi/content/shor… See below the #tweetorial from our very own @handlerkristina 👩‍🔬
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Jan Michler retweeted
Please retweet: new tenure-track assistant prof position at @ETH_BSSE @ETH_en. Great place to do amazing science; please apply or forward to people that might be interested!
Replying to @ItaiYanai
Fully agree. @ETH_BSSE actually encompasses 20 labs, pretty evenly distributed across theory, engineering, and experimental biology. If you're interested in cross-fertilization, please have a look at our open tenure-track position (posted today): ethz.ch/en/the-eth-zurich/wo…
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Jan Michler retweeted
So happy to share this! You thought sequencing #granulocytes was tough? Try #eosinophils! These elusive little cells gave us a hard time, but there it is 👉tinyurl.com/yur958bn. 🧵 below

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Check out our new preprint from a great collaboration with @sarahadamo from the Boyman lab at @Unispital_USZ on bioRxiv: CD8 T cell signature in acute SARS-CoV-2 infection identifies memory precursors. doi: doi.org/10.1101/2021.07.22.4…
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2) This is the first description in humans of a trajectory of memory CD8 T cells differentiating from Teffector/TEM to TEMRA with a concomitant upregulation of TCF1 after viral infection, revealing that CD8 TEMRA constitute the main memory phenotype in periph. blood (Fig.3a-c)
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3) By longitudinally tracking SARS-CoV-2 specific CD8 T cell clones, we find that cytokine signaling marks cells destined to become memory, while mTOR signaling and a strong proliferative transcriptional signature correlate with clonal contraction and disappearance (Fig.4 e,f)
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