Wow! $380 in annual medication costs can yield $9,780 to $23,773 in net annual healthcare cost savings in patients with HFrEF @AHAScience @American_Heart @ACCinTouch @HFSA @AAHFN @robmentz @MKIttlesonMD @ankeetbhatt @JavedButler1 @MariellJessup @HeartDocSadiya @paheidenreich

Excess and Dysfunctional Fat as a Primary Driver of Heart Failure With Preserved Ejection Fraction: From Institutional Recognition to Clinical Integration. doi.org/10.1016/j.jchf.2026.… Contributions from Baim faculty, @lamcardio and @JavedButler1. #BaimInstitute #ClinicalResearch

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This is wonderful news Shahzeb. I'm thankful to have the opportunity to collaborate with you and @JavedButler1

Screening and Treatment Using a Risk-Based Approach with NT-proBNP Guidance in Diabetes Mellitus: The STRONG-DM Pilot Study. doi.org/10.1016/j.jchf.2026.… Contributions from Baim faculty, @ambarish4786 and @JavedButler1 #BaimInstitute #ClinicalResearch

Looking forward to Co-Chairing this exciting Think Tank on HF prevention with the incomparable @JavedButler1

The DCRI and @CVCTForum have launched "Pathway to Prevention," an initiative to build regulatory and clinical pathways for cardiovascular prevention therapies. Three programs multiple stakeholders = closing the gap between science and policy. dcri.org/news/dcri-cvct-laun… #Prevention

Anti Drone by Rishabh Pant

✅Excited to receive NIH R01 award to study rapid/simultaneous initiation of GDMT in CKD 📌Usual practice is slow initiation which can take years. RAPID-CKD trial will see if rapid administration of GDMT in CKD is feasible, safe and effective @JavedButler1 @f2harrell #TShafi

Publication alert in @JACCJournals Pleased to share our editorial co-authored with Tariq Ahmad on the simultaneously published ALLEVIATE-HF trial, led by @JavedButler1 et al. ALLEVIATE-HF reinforces an important lesson for remote monitoring in heart failure: the hard part is no longer simply detecting risk. The hard part is reliably converting that risk signal into timely, accountable treatment. The trial showed that algorithm-based alerts can identify meaningful HF risk, and the nurse-facilitated PRN diuretic pathway appeared safe. But too many alerts did not lead to timely action. That execution gap likely blunted the clinical impact. Our take-home message: Prediction is not intervention. Alerts are not treatment. Workflow is therapy. The next generation of HF monitoring studies should define the alert-to-action pathway as the true intervention, with clear defaults, rapid response expectations, escalation pathways, and closed-loop accountability. Better sensors and better algorithms matter. But better systems may matter even more. kwnsfk27.r.eu-west-1.awstrac…

While meta-analysis of all 14 RCTs demonstrate benefit with ARNI for HF 🏨 and all-cause mortality vs ACEi or ARB control, the findings suggest lesser benefit in EF >40% and in post MI LVD These trials are S/V vs active control. Compared to imputed placebo the benefits even ⬆️⬆️

What's the weight of PARADIGM? What are results if omit it? What are results if only include trials with adequate active control (same dose Val or higher ACEi)?

💊 ARNI for HFrEF ❤️‍🩹 Benefits>>>potential risks ⏱️ Rapid ⬇️ events 🥇First line over ACEI or ARB ⚖️ High value 🔰No significant heterogeneity of treatment effects 🎯 The most precision guided and personalized approach to use: ✅ Treat all eligible individuals w/o CIs

Anti-inflammatory effects of oral NLRP3 inhibition with ruvonoflast among individuals at elevated cardiovascular risk. doi.org/10.1016/j.jacc.2026.… Contributions from Baim faculty, @JavedButler1 and @ProfKausikRay. #BaimInstitute #ClinicalResearch #Cardiology

Risk-Based Nurse-Managed Personalized Heart Failure Interventions: The ALLEVIATE-HF Trial. doi.org/10.1016/j.jacc.2026.… Contributions from Baim faculty, @JavedButler1. #BaimInstitute #ClinicalResearch #Cardiology

Obesity: a driver in #HFpEF, but in #HFrEF? An amplifier with a paradox. Does treating #obesity change disease course in HFrEF? No dedicated HFrEF trial has answered that yet. jacc.org/doi/10.1016/j.jacc.… #JACC @ShelleyZieroth @ShahzebKhanMD @JavedButler1

Anti-inflammatory effects of oral NLRP3 inhibition with ruvonoflast among individuals at elevated cardiovascular risk. doi.org/10.1016/j.jacc.2026.… Contributions from Baim faculty, @ProfKausikRay and @JavedButler1. #BaimInstitute #ClinicalResearch

Mitral transcatheter edge-to-edge repair and outcomes according to baseline health status: the RESHAPE-HF2 trial. doi.org/10.1093/eurheartj/eh… Contributions from Baim faculty, @JavedButler1. #BaimInstitute #ClinicalResearch

Experience is that can be safely and effectively achieved at scale with a multitude of patient-centered clinical benefits

Simultaneous or Rapid Initiation of Combination Therapy for Heart Failure With Mildly Reduced and Preserved Ejection Fraction Need for a fundamental shift in how we implement HFmrEF/HFpEF therapy in clinical practice doi.org/10.1001/jamacardio.2…