Neuroscientist, oligodendrocyte lover, Emmy-Noether fellow, mum
Joined December 2017
- Tweets 539
- Following 233
- Followers 629
- Likes 1,353
24 Photos and videos
Jan 16
I dont know how much science is still happening here...but lets see.
We have just released the first major paper of the Jäkel lab!
biorxiv.org/content/10.64898…
Looking at scRNA-seq in human AD brains with a major focus on oligodendrocytes, we made some interesting findings:
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Jan 16
1) bioinformatically, MT-genes are not always a good marker for bad quality cells and this approach should be reconsidered. 2) cellular pathology can look quite different in different brain regions and 3) oligodendrocytes (and other cells) downregulate canonical markers in AD.
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7 Aug 2025
Working part time as a parent in certain positions is probably the biggest scam. You are still expected to do the same amount of work in less time for less money.
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9 Jul 2025
Really emjoyed our session yesterday afternoon at #GLIA2025 on oligodendrocytes with @LuiseASeeker @GoCasteloBranco and others. We had a brilliant discussion aftwrwards. The glia community is always great!
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Sarah Jäkel retweeted
8 Jul 2025
Excited 2 be in Marseille for our symposium on understanding human oligodendroglia: a lifespan perspective at #GLIA2025. Join the brilliant @GoCasteloBranco, Sarah Jäkel, Nina Kazakou, Sunniva Bøstrand and myself. We are presenting exciting human data generated with @10xGenomics.
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Sarah Jäkel retweeted
13 Feb 2025
Hurler et al. report that fixation times affect mRNA detection in post-mortem human brain tissue, highlighting the need for standardised protocols to ensure reliable and comparable results in mRNA studies. Read at:buff.ly/4hSYhYA @JekyllSarah #mRNA #neuroscience
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Sarah Jäkel retweeted
11 Feb 2025
onlinelibrary.wiley.com/doi/…
Our paper is now out in GLIA! Excellent work led by @vidramesh and supported by @sidb_edinburgh. Thank you to everyone involved, especially to @e_tsou @Ioannakougianou @odando @Zrile
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Sarah Jäkel retweeted
31 Jan 2025
Our new pipeline is out! In this work we detail an ex vivo versatile platform for assessing myelin dynamics of hiPSC oligodendroglia.
🔗 Check it out @STARProtocols: doi.org/10.1016/j.xpro.2025.…
Huge thanks to my mentor @ErinMGibson and collaborators @LidaZoupi and @AnnaWilliamsLab!
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27 Jan 2025
Today marks a special day in my career - I received the official document that as of February, I will be a professor at TU in Munich.
There are certainly many people who supported me all along the way to achieve this goal. I am really looking forward to the next steps.
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23 Jan 2025
So happy to be involved in this project. Very important work linking amyloid and tau pathology.
science.org/doi/10.1126/scit…
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8 Jan 2025
Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article together with @burbulla_lab - and be certain that this topic is just at the beginning of being explored!
journals.plos.org/plosbiolog…
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Sarah Jäkel retweeted
23 Dec 2024
Neuroinflammation in Alzheimer disease:
I feel very privileged to have contributed to this excellent review led by Prof. @michael_heneka together with other leading experts in the field.
nature.com/articles/s41577-0…
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20 Dec 2024
So glad to see this work finally out. A huge collaborative effort, and besides the biological findings, also a brilliant resource.
sciencedirect.com/science/ar…
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Sarah Jäkel retweeted
Positive #MS research news just before Christmas!
A team co-led by @AnnaWilliamsLab has published gene expression findings from post-mortem samples that separate MS brain samples into 4 groups. Paves the way for personalised treatments.
More at annerowlingclinic.org/about/…
ALT Graphical abstract illustrating the main findings of the publication
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28 Nov 2024
The first paper of the Jäkel lab is published!
Are you working with post-mortem brain tissue and want to detect RNA in FFPE tissue? Then you should consider the fixation time before your experiment.
Nice collaboration with @liebscher_lab
doi.org/10.1093/braincomms/f…
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27 Nov 2024
It was a great pleasure to host Goncalo Castelo-Branco @GoCasteloBranco today at our TRR274 seminar today. Lots of interesting techniques and data!
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21 Oct 2024
Interested in what happens with glia in Huntington's disease? Check out this new publication.
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16 Oct 2024
Check out this fantastic work from @LenaSpieth @StefanBerghoff and others! A new role for microglia and APOE in plaque seeding in AD. And I am glad I was able to help a bit.
16 Oct 2024
🚨NEW PAPER ALERT 🚨 Our paper just got published in @ImmunityCP ! From Munich with 🥨 Check it out here: cell.com/immunity/fulltext/S… @Seiji_Kaji, @StefanBerghoff, Mikael Simons #apoe #Alzheimers #microglia 1/9
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Sarah Jäkel retweeted
2 Oct 2024
Early Career Researchers (ECRs) are the future of MS Research.
Professor Anna Williams tells us 7 things we should know about ECRs and how important it is to support their innovative work.
➡️ MS HISTORY MAKERS: mssoc.uk/4gCtYWc
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24 Sep 2024
I currently feel that!
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