A fantastic new #zebrafish model of uveal #melanoma from the lab of @TheKennyLab. This demonstrates the power of modeling rare but difficult to treat cancers, opening up new avenues to understand the biology and find new treatments. It has been really nice seeing this story evolve and congrats on this beautiful work: aacrjournals.org/cancerres/a…

A special thanks to Board Chair, Doug Brodman and his wife, Terry, for hosting their fifth fundraiser in Naples, Florida. Since its inception, this event has raised more than $300,000 to support young melanoma investigators—fueling breakthroughs from the discovery of a promising immune cell linked to improved patient outcomes to the development of a clinical trial enhancing TIL therapy for advanced melanoma. Florian Karreth, PhD (@KarrethLab), MRF research grant recipient and researcher from @MoffittNews shared updates on the impact of basic science research and the profound impact that early funding of innovative science has on long term outcomes for melanoma patients.

🚨🚨🚨Only 3 days left to apply for this incredible opportunity and to be considered for a nomination for the highly prestigious USF Presidential Doctoral Fellowship. #graduateschool #cancerresearch #phd

Lead by Xiaonan Xu, our paper describing Fra1 as a driver of #melanoma #metastasis is now published in Oncogene nature.com/articles/s41388-0…

Join our PhD program at Moffitt Cancer Center. We provide a world-class education in cancer biology, offer exquisite research infrastructure, and have fantastic labs and a wonderfully collaborative environment. And we are growing, i.e., offers will not be rescinded!

Researchers at Moffitt Cancer Center have been awarded a $22.4 million grant from the U.S. Department of War to lead groundbreaking studies and clinical trials for leptomeningeal disease. @moffittnews @moffittresearch newswise.com/articles/moffit…

From the biology of melanocytes to pigmentation conditions and melanoma - we have it all! Join us in Tampa in March 2026 (great time to escape the cold) for the Annual Meeting of the @PASPCR1

Interested in antisense #RNA and their contributions to #melanoma formation? Check out our latest paper: CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma: Cell Reports cell.com/cell-reports/fullte…

This was fun to write and will be a useful resource for the melanoma field

Well deserved recognition for @NicolMecozzi who also was recently awarded a @theNCI F99 grant

Wonderful news for the lab. Congrats @NicolMecozzi

Another preprint from our group, this one describing how the transcription factor FRA1 promoted #melanoma metastasis

Had a great time today touring the future Moffitt Discovery & Innovation Center! Excited for this new chapter for our Basic Science Division @MoffittNews lead by the amazing @LabElsaFlores

Preprint alert: check out our new genetically engineered mouse model of uveal melanoma, which recapitulates many aspects of the human disease including phenotypic plasticity

Live from #AACR25: Kaizhen Wang (@Kaizhen20) from the @KarrethLab discusses how MYBL2 drives melanoma through a surprising mechanism, non-canonical RNA binding. This newly uncovered function reveals how MYBL2 reshapes gene regulation and promotes tumor growth, offering fresh insight into melanoma progression. Key insights: •MYBL2 is pregulated and plays an oncogenic role in melanoma while represents a melanoma vulnerability • MYBL2 binds RNA in melanoma but not in melanocytes, and it promotes melanoma growth through its RNA binding function. • RNA binding of MYBL2 enhances its association with chromatin and drives a transcriptional program which associated with poor patient outcomes. • Distinct melanoma RNA background is the main determinant to enable MYBL2 RNA binding in melanoma cells Read more: bit.ly/4cSt6eP #MoffittAACR25

While at #AACR25, Kaizhen Wang (@Kaizhen20) from the @KarrethLab shares new insights on melanoma progression, revealing how non-canonical RNA binding by the MYBL2 transcription factor plays a key role in driving the disease. Read more: bit.ly/4cSt6eP #MoffittAACR25