Thanks to discovery science/RCTs, there is now quadruple GDMT for HFrEF, which can ⬇️ ☠️ by ~75%, with clinical benefits emerging within the 1st few days of initiation
Yet, due to old algorithms, misperceived risk, and therapeutic inertia ▶️
9/10 pts ☠️ prior to full Q-GDMT Rx