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Krische Lab @KrischeLab

Synthetic Methods and Natural Product Synthesis @ UT Austin

Joined January 2019
  • Tweets 197
  • Following 132
  • Followers 4,196
63 Photos and videos
Chiral-at-metal-and-ligand catalyst unlocks enantioselective alkynylation that is air/water tolerant and base-free. doi.org/10.1002/anie.9580914

A Ruthenium‐(Ph‐BPE) Catalyst for Asymmetric Alkynylation of Fluoral: Enantioselection From 1 of 12...

The first enantioselective alkynylations of aqueous fluoral are described. These processes are catalyzed by an iodide-bound ruthenium-(Ph-BPE)-catalyst; an octahedral metal complex that can exist as...

onlinelibrary.wiley.com
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For long-term solutions, look beyond backward-facing approaches. doi.org/10.1021/acs.chemrev.…

Metal-Catalyzed Reductive Coupling of Aryl Halides beyond Premetalated Reagents or Metallic...

Biaryl motifs figure prominently in commercial pharmaceutical and agrochemical ingredients and are used widely in organic optoelectronic materials. Traditional palladium-catalyzed cross-coupling...

pubs.acs.org
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Polyketide total synthesis reinvented! Congrats to Kate, Yoon and team Warwick! doi.org/10.1021/jacs.5c22672

Total Synthesis of iso-Gladiolin Methyl Ester (Lagriene Methyl Ester) via Catalytic Asymmetric C–C...

Gladiolin, a specialized metabolite of Burkholderia gladioli, is an antitubercular 22-membered macrolide that inhibits RNA polymerase at a site distinct from rifampicin, making it effective against...

pubs.acs.org
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A practical butadiene-mediated carbonyl crotylation after nearly 2 decades of work! doi.org/10.1021/acs.orglett.…

Enantioselective Butadiene-Mediated Aldehyde Crotylation of Alcohol Proelectrophiles: RuHCl(CO)(P...

The catalyst assembled from inexpensive, air-stable RuHCl(CO)(PPh3)3, JOSIPHOS (SL-J502-1), and NaI affects anti-diastereo- and enantioselective crotylation of alcohol proelectrophiles via hydrogen...

pubs.acs.org
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Yoon Cho will join the process team at Vertex – Congrats!
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TexSyn-VII will be held May 29-30, 2026 at UT Dallas. Come see great synthetic chemistry from the Lone Star State, y’all! texsyn.org/

Home - TexSyn

Explore cutting-edge research in synthesis and catalysis at TexSyn VII, the leading synthetic chemistry conference in Texas.

texsyn.org
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A big congratulations to Kate, Yoon and Dana for completing their PhD theses!
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One more gem carved from chaos by Seoyoung, Sarah, Erin and Brandon. doi.org/10.1021/jacs.5c15097

Enantioselective N-Heteroaryl C–H Functionalization for Piperidine-Azine Conjugation: Alkynes as...

The first enantioselective N-heteroaryl C–H functionalizations via dearomative addition-hydrogen auto-transfer are described. Using a ruthenium catalyst assembled from RuHCl(CO)(PPh3)3, (R)-Cy-BINAP...

pubs.acs.org
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Krische Lab retweeted
The Hull Group @ UT Austin@hull_group
24 Oct 2025
Great news! The deadline for poster presenters and attendees to register for the Women in Catalysis and Synthetic Chemistry Symposium has been extended to November 3rd. We hope to see y'all there! Registration link: forms.gle/GKqfXG2UZkR2r1ySA
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Hydrogen is the forward-facing choice for reductive cross-coupling. doi.org/10.1021/jacs.5c15725

Hydrogen-Mediated Reductive Cross-Coupling of Aryl Iodides with Activated Aryl and Heteroaryl...

Hydrogen-mediated reductive cross-couplings of aryl iodides with activated aryl and heteroaryl bromides are described, along with related homocouplings (Ullmann reactions) and vinylic reductive...

pubs.acs.org
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Reminder that the third WCSC event is Nov 15th! Chemistry students in Texas are encouraged to register for the event and consider presenting a poster or speed talk. This event is FREE and will be a full day of networking and chemical insights! Hope to see you there!
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Great to welcome back Dr. Seung Wook Kim of BMS for a distinguished alumni lecture!
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It was our pleasure to welcome Prof. Daniel Werz of Freiburg University for a research seminar in Austin!
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The Austin-Gifu chemistry connection continues with a visit from Prof. Eiji Yamaguchi!
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Congrats to Cate, Peyton and Zach – diols are twice the alcohol and twice the fun! doi.org/10.1021/jacs.5c09358

anti-Diastereo- and Enantioselective Ruthenium-Catalyzed C–C Coupling-Oxidative Lactonization of...

Reported methods for enantioselective oxidative lactonization affect desymmetrization of prochiral or meso-diols, and processes where C–C bond formation accompanies oxidative lactonization are...

pubs.acs.org
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It's official! The third biennial WCSC is Nov. 15th, co-hosted by the @hull_group. Undergrads, grad students, post-docs, and faculty are welcome to register here: forms.gle/NLa2XEzH9URLZnjF8. Thank you to our sponsors @Amgen @genentech @pfizer @AmerChemSociety. Hope to see you there!
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Many thanks to former group members for their hospitality in Tokyo!
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Many thanks to colleagues at Tohoku University for a wonderful visit!
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Return of T-Schempp (aka Tabitha), destroyer of Soraphen and star alumnus at Eli Lilly, San Diego!
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Congratulations to Prof. Yu-Rong Yang on the total synthesis of rubriflordilactone A via late-stage Ir-catalyzed 2-(alkoxycarbonyl)allylation! doi.org/10.1021/jacs.5c05000
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