#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By @EMBOPress, @RockUPress and @CSHLPress.
Joined September 2017
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A newly established microscopy-based live-cell assay reveals that CD40 and CD70 selectively promote the arrest of CD4⁺ and CD8⁺ T cells on antigen-presenting cells, uncovering a novel function for co-stimulatory molecules. hubs.la/Q04ksdMg0
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Check out this recently published paper in LSA:
GPLD1 is a scavenger carrier mediating lysosomal degradation of extracellular aberrant proteins
@Chiba_Univ_PR @ReviewCommons ➡️ hubs.la/Q04ksBP20
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This review in our Genetics, Genomics, and Epigenomics collection synthesizes findings from genomic, molecular, and disease studies that chromatin organization dynamically shapes diverse DNA repair pathways. @uzh_vetsuisse @fenssabanci @vogulcankaya hubs.la/Q04l9dVq0
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Read the full paper here: life-science-alliance.org/co…
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🧬 A specific SLC2A10 gene variant triggers macrophage metabolic reprogramming, directly fueling inflammatory bone damage in CNO. This shifts our understanding of chronic bone inflammation and opens up entirely new therapeutic possibilities. 🦴🔥 hubs.la/Q04kfbx_0
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Immunology collection: BCL6 limits CD8 T cell responses to tumors by inhibiting Glut3 expression. Conditional deletion of Bcl6 in activated CD8 T cells or pharmacological inhibition of BCL6 in mice represses tumor growth life-science-alliance.org/co…
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Full paper here: life-science-alliance.org/co…
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Discover important benchmarking studies, resources, and methodologies.
Read articles in the Genetics, Genomics, and Epigenomics collection.
hubs.la/Q04kgcx60
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This work in our Immunology Collection characterizes the Q367H variant in MFN2, identified in a patient with myopathy but no peripheral, & shows a novel way in which MFN2 dysfunction causes disease by promoting mtDNA release & subsequent inflammation.
life-science-alliance.org/co…
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Read the full paper here: life-science-alliance.org/co…
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How do T cells know when to stop? This new 'scan and stop' assay reveals CD40 and CD70 as selective regulators of CD4 and CD8 T cell arrest on APCs, lowering the threshold for stable synapse formation. Check it out! life-science-alliance.org/co…
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More in our Cancer Biology collection: Pipeline to evaluate YAP-TEAD inhibitors indicates TEAD inhibition represses NF2-mutant mesothelioma
life-science-alliance.org/co…
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Full paper 👉 life-science-alliance.org/co…
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This study reveals that GPLD1 acts as a novel scavenger carrier that directly binds and delivers extracellular aberrant proteins, such as serum amyloid A1, to lysosomes for degradation via cell surface heparan sulfate.
@Chiba_Univ_PR @ReviewCommons
life-science-alliance.org/co…
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In our Immunology Collection: Two novel fluorescent reporter strains enable visualization of MHC class II cells and CD8 T cells, revealing the dynamics of inflammatory responses in vivo. @urmedicine
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Read the full paper here: life-science-alliance.org/co…
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In our June issue, discover the largest ever mutational library of C elegans strains, interplay between ciliogenesis and epigenetics, and reprogramming Tregs to control asthma. Read these and more:
life-science-alliance.org/co…
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This study reveals a potential link between an SLC2A10 variant, macrophage metabolic reprogramming, and inflammatory bone damage in CNO.
life-science-alliance.org/co…
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Take a look at this recently published paper in LSA 👇
Annulus fracture underlies radiation-induced sperm dysfunction revealed by multimodal nano-imaging
hubs.la/Q04j9VKx0
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